DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and smurf2

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_031750530.1	Gene:	smurf2 / 100038194	XenbaseID:	XB-GENE-481391	Length:	752	Species:	Xenopus tropicalis

Alignment Length:	1060	Identity:	479/1060 - (45%)
Similarity:	592/1060 - (55%)	Gaps:	320/1060 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RRNGTHKVRITILCARNLARKDLFR-LPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLG 71
            ||||..|:|:|:|||:||.:||.|. ||||||||.|||:||.:||:..|::||||||.||||::|
Frog     7 RRNGPVKLRLTVLCAKNLVKKDFFTGLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIG 71

  Fly    72 IGDAITITVWNQRKIHK--GSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIIS 134
            ..|:|||:|||.:||||  |:|||||||:.:..|..||..|:|||||.||.|:|::.|||||::|
Frog    72 KSDSITISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVS 136

  Fly   135 LLSKDGPSSGNPLAIVGPSGDVRGPSEDDSS---EDSLPEGWEERRTDNGRVYYVNHATKSTQWD 196
            |.|:|...||..:.              |.|   ::.||:|||||||.:||:.|:||.|::|||:
Frog   137 LQSRDRIGSGGQVV--------------DCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWE 187

  Fly   197 RPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRH 261
            ||.:|                     :.:..:|..|
Frog   188 RPTRP---------------------ASEYSSPGRP----------------------------- 202

  Fly   262 STEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLH 326
                ||....||    ||::.|          |.::.|       .|::|...
Frog   203 ----LSCFVDEN----TPITGT----------NGATCG-------QTSDPRIA------------ 230

  Fly   327 SNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDA 391
              :..|::.:|                  :||::..
Frog   231 --ERRVRSQRH------------------RNYMSRT----------------------------- 246

  Fly   392 ATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQR 456
                          |..:||
Frog   247 --------------HLHTPP--------------------------------------------- 252

  Fly   457 SQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEM 521
                                                                     |||.|||.
Frog   253 ---------------------------------------------------------DLPEGYEQ 260

  Fly   522 RTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNRT 586
            ||||||||||.|..||||||||||:|||.  .::..:.:||||.|||.|.||:||||||||||||
Frog   261 RTTQQGQVYFLHTQTGVSTWHDPRVPRDL--SNINCEELGPLPPGWEIRNTATGRVYFVDHNNRT 323

  Fly   587 TQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTT 651
            |||||||||.::..::.|                     .........|||..|...
Frog   324 TQFTDPRLSANLHLVLNR---------------------QNQQLKEQQPPQVVPLCQ-------- 359

  Fly   652 TTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESY 716
                    :||..:.|     .:|:|:||||.||:.||.||...|||:||||:||||.|||||||
Frog   360 --------LPDEVECL-----TVPRYKRDLVHKLKILRQELSQQQPQAGHCRIEVSREEIFEESY 411

  Fly   717 RLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPD 781
            |.:||||.||:.||||:||:|||||||||||||||:|||.|||||.||||||||||.||||||||
Frog   412 RQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPD 476

  Fly   782 SGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWML 846
            |.|||:||||||||||.:|:||||||.:|||||.|||||||.|||||.|:|.||||||.||.|:|
Frog   477 SAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWIL 541

  Fly   847 ESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQ 911
            |::|:|:::.||.||::::|.|:.|||||.|.|||||||.|:|||:||||:||:||||.||||||
Frog   542 ENDITGVLDHTFCVEHSAYGELIQHELKPSGKSIPVTEETKKEYVRLYVNWRFLRGIEAQFLALQ 606

  Fly   912 KGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEM 976
            |||.|:||.|||:.|||:||||:|.|:..||||||::||||||||.::..|.|||:.|||:..|.
Frog   607 KGFNEVIPQHLLKAFDEKELELIICGLGKIDVNDWKSNTRLKHCTADSNIVKWFWKAVESFDEER 671

  Fly   977 RARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETY 1041
            |||||||||||||||||||:|||   ||.|||||||| ..|..|.|||||||||||||:||||||
Frog   672 RARLLQFVTGSSRVPLQGFKALQ---GAAGPRLFTIH-QIDASTNNLPKAHTCFNRIDIPPYETY 732

  Fly  1042 QLLCDKLTQAVEETCGFAVE 1061
            :.|.:||..|:|||||||||
Frog   733 EKLYEKLLTAIEETCGFAVE 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	75/123 (61%)
		WW	169..198	CDD:278809	18/28 (64%)
		WW	514..546	CDD:197736	26/31 (84%)
		WW	562..594	CDD:197736	27/31 (87%)
		HECTc	702..1058	CDD:238033	260/355 (73%)
		HECTc	726..1058	CDD:214523	241/331 (73%)
smurf2	XP_031750530.1	C2_Smurf-like	13..138	CDD:176028	76/124 (61%)
		PRP40	156..>237	CDD:227435	35/169 (21%)
		WW	160..189	CDD:395320	18/28 (64%)
		WW	253..284	CDD:197736	25/30 (83%)
		WW	299..331	CDD:197736	27/31 (87%)
		HECTc	397..749	CDD:238033	260/355 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	470	1.000	Domainoid score	I444
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	714	1.000	Inparanoid score	I631
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103319at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm48794
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X2041
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.090