DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and plekha7b

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_021327578.1	Gene:	plekha7b / 100005106	ZFINID:	ZDB-GENE-091014-2	Length:	1359	Species:	Danio rerio

Alignment Length:	1072	Identity:	220/1072 - (20%)
Similarity:	344/1072 - (32%)	Gaps:	316/1072 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 DSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAG 231
            |:||:.|......:|||:::|..|:.|.|..||....|.|.|...              ...|.|
Zfish     8 DTLPDHWSYGVCRDGRVFFINDKTRDTTWLHPRTGEPVNSGHMIR--------------SDLPRG 58

  Fly   232 PTRSTT---CTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTS------------------ 275
            .....|   .:..:|:..||...        ||  .:...:..|||.
Zfish    59 WEEGFTEEGASYFINHNQRSTTF--------RH--PVTGHISSENTDFILQDQANLRMSKPPPEA 113

  Fly   276 --PT----TPVSATTTPGKKTSSSNSSSAGGR---------TLEQRPTNEPATPTS---STTSAS 322
              |:    :.|:.:::|...||.|.:....|:         ::::.| |.|.....   ...|:.
Zfish   114 RPPSMVSESSVAISSSPADATSGSRNLKPSGKVHCFGKRDHSIKRNP-NVPVVVRGWLYKQDSSG 177

  Fly   323 VRLHSNDNHV---------KTPKHQT-NGHAPPESTPTSP-----------------TGQQNYV- 359
            :||......|         |..:.:| .|..|..|...||                 ||.::|:
Zfish   178 MRLWKRKWFVLSDYCLFYYKDSREETVLGSIPLPSYVISPVGPEDHISRKYAFKACHTGMRSYIY 242

  Fly   360 NGNAQNGSTSGNGSGQ----AAQPQSASNGW--TQEDAATTTSPSTTTSPPRHSQSPPTPNISPP 418
            |.|:..||.:.:...:    :|..|...|||  ....||...|........|.|:  |..:..|.
Zfish   243 NKNSLIGSQAEHCGMRTYFFSADTQEDMNGWIRAMNQAALMQSHGMKREAERSSK--PEQHAVPQ 305

  Fly   419 ASVTPSANGNVHSPNANST--------PAGSGGGSRSYT---------AATPGQRSQRRSSRQQG 466
            .:...|:.|:..:.:|..|        |...|.....|:         ..:||:......| |.|
Zfish   306 TNHFSSSKGSSQAESAQQTHIEVAELRPQRDGDECYVYSKDITEDPVKLMSPGEMEMEALS-QSG 369

  Fly   467 EESSTRRRSSRGT-RNGGTSGGGGGGGSG------------------QRYASAA-------IAAA 505
            ..|  |..|:..| |||..|.|.....:|                  ||..:.|       :...
Zfish   370 AHS--RPPSTVPTQRNGLPSSGIPPDQNGNVVYKRGLVPRTDTEKKVQRKTALAQVEHWVKVQKG 432

  Fly   506 NQAARPFLD---------LPPGYEMRTTQQGQVYFYHIPTGVSTWHDPR-IPRDFDTQHLTLDAI 560
            :..:.|..:         |.|...|..|.|.........:|.|:...|| :|.|:...|   |.:
Zfish   433 DPKSHPTAEYTLPRRTPPLQPKSVMMDTYQSLPKTTRHHSGSSSPPVPRNLPSDYKYAH---DRL 494

  Fly   561 GPLPSGWEQR-KTASGRVYFVDHNNRTTQF-----TDPRLSGS----------ILQMIRRGTVPP 609
            .......::| .|..|.|:.:....:..||     |.|..:|.          .|:|.|..:|||
Zfish   495 SHFRMSTDERMATKEGMVWQLYEWQQRQQFRHGSPTAPIYTGPDYMDTSAFRVTLEMPRSISVPP 559

  Fly   610 TSAANAGTPAPPSATPATPSAAAAVPPQA--TPASNAT--PTTLTTTTNPPHRIVPDLPQGLLEG 670
            :..     ..|||..|     :.::.|:.  |||...|  |.....|.:.|   :...|:|:.
Zfish   560 SPC-----DMPPSGHP-----SKSLSPRRPHTPADRVTVRPLDDFATVDTP---ILGSPRGIC-- 609

  Fly   671 ADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIF----EESYRLIMKMRAKDMRKRL 731
                     ..:.|...|  |.::| |..|:....||...:.    ||...|::::| :...|..
Zfish   610 ---------SQISKTSQL--ERRSM-PTMGYITHTVSAPSLHGKTPEELTLLLIQLR-RHRAKLA 661

  Fly   732 MVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLF--QYSRDDHYTLQINPDSGVNPDHLSYFHF 794
            .|:            :..:.||     .|...||.  ....||.| :|:..|       |.|...
Zfish   662 SVR------------SDTFTHL-----QNQHNGLSGPSLQADDTY-IQLKKD-------LEYLDL 701

  Fly   795 VGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHR-----SLTWMLESNISGI- 853
            ..:::...::.....|.      .|....:|:.:.:.: :|..|.|     .:...||:.|..:
Zfish   702 KMKSIEPLIYSVTGRDS------LKDRPPRPVKIAESD-IDVKLSRLCEQDKILQELEARIRTLK 759

  Fly   854 -----IESTFSVENNSFGALVVHELKPGGA-SIPVTEENKREYVKLYVNYRFMRGIEQQFLALQK 912
                 :||...|.:..   :..::.:|..| .|...::..||.|   |:.|  ..|.|....::.
Zfish   760 EDKDKLESVLDVSHQQ---MEQYQDQPAHAEKIAYQQKLLREDV---VHIR--ADISQVSTEMEN 816

  Fly   913 GFCELIPSHLLRPFD-----------------------EREL---ELVIGGISSIDVN-----DW 946
            .:.|.  |||.|..|                       .:||   |.|:.|:||...|     |.
Zfish   817 AWSEY--SHLERDVDRLRSALQDQMTHSALSQQEKSQMRKELWRIEDVLAGLSSSKANYRVIIDS 879

  Fly   947 RNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFT 1011
            ..|..........|.:.|         :..|.|.|......|.||........|...|..|   :
Zfish   880 VRNPGESGPLPAITPMHW---------NTARERKLVPSASLSAVPSLSDSPSMGELKAAQP---S 932

  Fly  1012 IHLTADVP--TQNLPKAHTCFN----RIDLPP 1037
            .||:...|  .|.|..:||...    ..|.||
Zfish   933 PHLSPVQPCTQQPLQLSHTALTPKWPEEDAPP 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809	10/28 (36%)
		WW	514..546	CDD:197736	9/41 (22%)
		WW	562..594	CDD:197736	8/37 (22%)
		HECTc	702..1058	CDD:238033	79/391 (20%)
		HECTc	726..1058	CDD:214523	73/363 (20%)
plekha7b	XP_021327578.1	WW	10..39	CDD:306827	10/28 (36%)
		WW	55..84	CDD:306827	8/38 (21%)
		PH_PEPP1_2_3	158..281	CDD:270068	26/123 (21%)
		SMC_N	645..>882	CDD:330553	54/279 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000