DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP54D and ARHGAP29

DIOPT Version :10

Sequence 1:NP_611236.2 Gene:RhoGAP54D / 36996 FlyBaseID:FBgn0034249 Length:1004 Species:Drosophila melanogaster
Sequence 2:NP_004806.3 Gene:ARHGAP29 / 9411 HGNCID:30207 Length:1261 Species:Homo sapiens


Alignment Length:691 Identity:134/691 - (19%)
Similarity:223/691 - (32%) Gaps:252/691 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 LTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSAHDCATVFKGFLSELPEPLLTDAHYPAH 193
            |..:|::|..|...:..:|...:::...| ::::.||:||...|.|.:|.:||||.:....|...
Human   700 LCLQGIYRVCGNKIKTEKLCQALENGMHL-VDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEF 763

  Fly   194 LQIAPLCQALNGQTTATAERQQHLLNSVQ-------------------LLLLLLPEEHRELLQHI 239
            :.:|...|.:|       |.|:...||::                   .||..||..:...|..:
Human   764 IDLAKEIQHVN-------EEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFL 821

  Fly   240 IEMLHAVAKHEKSNKMSADNLATLFTPHLICPRQLPPEVLHYQAKKMSS---IVTYMIVRGLDIF 301
            |..|..|..|.:.|||::.||..:|.|.||.||.....:......:.|:   :|.::|.....||
Human   822 IVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIF 886

  Fly   302 E---VPGKLSTDIRAYFLERKRKKTMSPEQ-TLDESISDV--STVNTVYTFVDRAATAAATNTNN 360
            :   .|..:...|.........|..:|||: .::.|:..:  |:...::|               
Human   887 DGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHT--------------- 936

  Fly   361 TDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQG-------TPLQLVVMNRLKNNEATRSAKSL 418
            :::| ::::....|..||.:         |||..|       ...||     |.:.||..:::.:
Human   937 SESE-SKIFERATSFEESER---------KQNALGKCDACLSDKAQL-----LLDQEAESASQKI 986

  Fly   419 GDSIKKHIFHKSLMSRTPKRVPPSFHLASGSETPNMS-HVKPPKMRVLFQSPTPPTPTSSTITSV 482
            .|            .:|||  |.|  |.|...|.|:. |....|:|                   
Human   987 ED------------GKTPK--PLS--LKSDRSTNNVERHTPRTKIR------------------- 1016

  Fly   483 SLSTNTRHQLQKSISSASLKIESSSSDSSSSCATSGSISAPVSRQQSKESPSGNGAAGASGQELD 547
                                                .:|.||.|......|:...........||
Human  1017 ------------------------------------PVSLPVDRLLLASPPNERNGRNMGNVNLD 1045

  Fly   548 EIDADCCVTPLKIMSAVAKQLIDKKSVA---------WDEHRLLEIEEYSNPSTPVQQSTRYKSE 603
            :.    |..|       |.:.:::|..|         :|:..|.:|::                 
Human  1046 KF----CKNP-------AFEGVNRKDAATTVCSKFNGFDQQTLQKIQD----------------- 1082

  Fly   604 PNLSSILPQVDAEEEDDGALTPIVEGRSTMVASSSHMGRSITRKLM----KGVSMGNLRFPFSTP 664
                        ::.:..:||    .::||:..|:...:.:|..|.    ..::......|::.|
Human  1083 ------------KQYEQNSLT----AKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEP 1131

  Fly   665 ETTKRLVRSVSATLRRRPS---------------------------------GEESKPC-PLAAD 695
                  ||||.....||.|                                 |.|.||. |.||.
Human  1132 ------VRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAV 1190

  Fly   696 APLLEDVDDSDEDDDHHGAVDED--DDDTLSENNGSSNELP 734
            .|        ..|.|.||.|.:.  |.|..|...|.:...|
Human  1191 PP--------GTDHDPHGLVVKSMPDPDKASACPGQATGQP 1223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP54DNP_611236.2 RhoGAP 107..313 CDD:470621 52/208 (25%)
ARHGAP29NP_004806.3 BAR 220..436 CDD:472257
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..501
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 541..600
C1_GMIP-like 611..661 CDD:410366
RhoGAP_PARG1 669..881 CDD:239874 48/188 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 981..1011 11/45 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1153 9/41 (22%)
PHA03247 <1121..1237 CDD:223021 27/117 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1178..1238 18/54 (33%)
Interaction with PTPN13/PTPL1. /evidence=ECO:0000269|PubMed:9305890 1258..1261
Blue background indicates that the domain is not in the aligned region.

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