DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP54D and ARHGAP29

DIOPT Version :9

Sequence 1:NP_001261060.1 Gene:RhoGAP54D / 36996 FlyBaseID:FBgn0034249 Length:1004 Species:Drosophila melanogaster
Sequence 2:NP_001315593.1 Gene:ARHGAP29 / 9411 HGNCID:30207 Length:1261 Species:Homo sapiens


Alignment Length:691 Identity:134/691 - (19%)
Similarity:223/691 - (32%) Gaps:252/691 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 LTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSAHDCATVFKGFLSELPEPLLTDAHYPAH 193
            |..:|::|..|...:..:|...:::...| ::::.||:||...|.|.:|.:||||.:....|...
Human   700 LCLQGIYRVCGNKIKTEKLCQALENGMHL-VDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEF 763

  Fly   194 LQIAPLCQALNGQTTATAERQQHLLNSVQ-------------------LLLLLLPEEHRELLQHI 239
            :.:|...|.:|       |.|:...||::                   .||..||..:...|..:
Human   764 IDLAKEIQHVN-------EEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFL 821

  Fly   240 IEMLHAVAKHEKSNKMSADNLATLFTPHLICPRQLPPEVLHYQAKKMSS---IVTYMIVRGLDIF 301
            |..|..|..|.:.|||::.||..:|.|.||.||.....:......:.|:   :|.::|.....||
Human   822 IVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIF 886

  Fly   302 E---VPGKLSTDIRAYFLERKRKKTMSPEQ-TLDESISDV--STVNTVYTFVDRAATAAATNTNN 360
            :   .|..:...|.........|..:|||: .::.|:..:  |:...::|               
Human   887 DGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHT--------------- 936

  Fly   361 TDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQG-------TPLQLVVMNRLKNNEATRSAKSL 418
            :::| ::::....|..||.:         |||..|       ...||     |.:.||..:::.:
Human   937 SESE-SKIFERATSFEESER---------KQNALGKCDACLSDKAQL-----LLDQEAESASQKI 986

  Fly   419 GDSIKKHIFHKSLMSRTPKRVPPSFHLASGSETPNMS-HVKPPKMRVLFQSPTPPTPTSSTITSV 482
            .|            .:|||  |.|  |.|...|.|:. |....|:|                   
Human   987 ED------------GKTPK--PLS--LKSDRSTNNVERHTPRTKIR------------------- 1016

  Fly   483 SLSTNTRHQLQKSISSASLKIESSSSDSSSSCATSGSISAPVSRQQSKESPSGNGAAGASGQELD 547
                                                .:|.||.|......|:...........||
Human  1017 ------------------------------------PVSLPVDRLLLASPPNERNGRNMGNVNLD 1045

  Fly   548 EIDADCCVTPLKIMSAVAKQLIDKKSVA---------WDEHRLLEIEEYSNPSTPVQQSTRYKSE 603
            :.    |..|       |.:.:::|..|         :|:..|.:|::                 
Human  1046 KF----CKNP-------AFEGVNRKDAATTVCSKFNGFDQQTLQKIQD----------------- 1082

  Fly   604 PNLSSILPQVDAEEEDDGALTPIVEGRSTMVASSSHMGRSITRKLM----KGVSMGNLRFPFSTP 664
                        ::.:..:||    .::||:..|:...:.:|..|.    ..::......|::.|
Human  1083 ------------KQYEQNSLT----AKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEP 1131

  Fly   665 ETTKRLVRSVSATLRRRPS---------------------------------GEESKPC-PLAAD 695
                  ||||.....||.|                                 |.|.||. |.||.
Human  1132 ------VRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAV 1190

  Fly   696 APLLEDVDDSDEDDDHHGAVDED--DDDTLSENNGSSNELP 734
            .|        ..|.|.||.|.:.  |.|..|...|.:...|
Human  1191 PP--------GTDHDPHGLVVKSMPDPDKASACPGQATGQP 1223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP54DNP_001261060.1 RhoGAP 107..313 CDD:295372 52/208 (25%)
ARHGAP29NP_001315593.1 BAR 220..436 CDD:299863
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..501
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 541..600
C1 612..657 CDD:197519
RhoGAP_PARG1 669..881 CDD:239874 48/188 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 981..1011 11/45 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1153 9/41 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1178..1238 18/54 (33%)
Interaction with PTPN13/PTPL1. /evidence=ECO:0000269|PubMed:9305890 1258..1261
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1453
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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