DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP54D and RGA1

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_014770.1	Gene:	RGA1 / 854294	SGDID:	S000005653	Length:	1007	Species:	Saccharomyces cerevisiae

Alignment Length:	1067	Identity:	203/1067 - (19%)
Similarity:	355/1067 - (33%)	Gaps:	361/1067 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 FDLPCHEIV------YEDKGKLKKWNRLSKKHRLGHGAAATSCAAGSASKSVGNSPTETLQQQID 109
            |.|.|||.:      ||:           ||.||              .|::.:.||..    ||
Yeast   118 FCLSCHEKLLAKRKYYEE-----------KKRRL--------------KKNLPSLPTPV----ID 153

  Fly   110 PGFLMHLQELKEFLML-EKNLTQEGLFRKAGAVSRQNELRMHIQHDKPLNLE--------LAGFS 165
            .|   |..|:....:| ||..:     |.|..|   ||:....:..|.:...        :.|::
Yeast   154 NG---HTDEVSASAVLPEKTFS-----RPASLV---NEIPSGSEPSKDIETNSSDIVPHFITGYN 207

  Fly   166 AHDCATVFKGFLSEL------PEPLLT-----DAHYPAHLQIAPLCQALNGQTTAT------AER 213
            ..|..:....|.|.:      ||...|     |....|....|.:  :||..|..|      ...
Yeast   208 DSDDNSGSSKFGSNVSIDVIGPEENSTEHVNDDVKEEAEAPSANM--SLNVATDPTLSCKEPPSH 270

  Fly   214 QQHLLNSVQL------LLLLLPEEHRELLQHII--EMLHAVAKHEKSNKMSADNLATLFTPHLIC 270
            .::|||...|      .|...|..:|   |.||  :.|....:.:..|. |:.|.:.|.|..|..
Yeast   271 SRNLLNKTPLRNSSGQYLAKSPSSYR---QGIIVNDSLEESDQIDPPNN-SSRNASELLTSVLHS 331

  Fly   271 P---------------------RQLPP----EVLHYQAKKMSSI---VTYMIVRGLDIFEVPGKL 307
            |                     .|:.|    :||:...::.:::   |..::.....:.::.|..
Yeast   332 PVSVNMKNPKGSNTDIFNTGEISQMDPSLSRKVLNNIVEETNALQRPVVEVVKEDRSVPDLAGVQ 396

  Fly   308 STDIRAYFLERKRKKTMSPEQTLDESISDVSTVNTVYTFVDRAATAAATNTNNTDTELAQLYAHI 372
            ......|.......|.....::|.....|: .:|         ..:.||...:::.:|:.
Yeast   397 QEQAEKYSYSNNSGKGRKISRSLSRRSKDL-MIN---------LKSRATGKQDSNVKLSP----- 446

  Fly   373 QSMPESSKKRRLIKQFNKQNGQGTP------LQLVVMNRLKNNEATRSAKSLGDSIKKHIFHKSL 431
            .|...|.:.:.|::..:...|..||      |.::|     ||:.:.:.|...|:
Yeast   447 ASKVTSRRSQDLMRDNDSHTGLDTPNSNSTSLDILV-----NNQKSLNYKRFTDN---------- 496

  Fly   432 MSRTPKRVPPSFHLASGSET-----PNMSHVKPPKMRVLFQSPTPPT--------PTSSTIT--- 480
                     .:..:.||.||     .|.|...|..:..|.|||..|:        |..|::|
Yeast   497 ---------GTLRVTSGKETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYRTPPLDSSLTFDR 552

  Fly   481 -SVSLSTNTRHQLQKSISSASLKIESSSSDSSSSCATSGSISAPVSRQQSKESPSGNGAAGASGQ 544
             :.|..:|..:.:.....:...::|:|.:.....       .......:|:..||
Yeast   553 RNGSSYSNQNYSIPSWQKTPKTQLENSDNFEEQK-------ETLYENSESRNDPS---------- 600

  Fly   545 ELDE--IDADCCVTPLKI--------MSAVAKQLIDKKSV--AWDEHRLLEIEEYSNPSTPVQQS 597
             ||:  :.|:..:..|||        ...:.|::.:.||:  |...|    ||.|::     :::
Yeast   601 -LDKEIVTAEHYLKQLKINLKELESQREELMKEITEMKSMKEALRRH----IESYNS-----EKN 655

  Fly   598 TRYKSEPNLSSILPQVDAEEEDDGALTPIVEGRSTMVASSSHMGRSI---------------TRK 647
            ..|.....||:..|.::  |...|...|:..     ||::|.:.||.               |.:
Yeast   656 KLYLDSNELSNNPPMIN--EISLGESPPVKH-----VATASSVARSSVKPKFWKFFSSAKPQTEQ 713

  Fly   648 LMKGVSMGNLRFPFSTPETTKRLVRSVSATLRRRPSGEESKPCPLAADAPLLEDVDD-SD----- 706
            .::|||..|          |..:|:|....|....||..|.  .|....|:|::.:: ||
Yeast   714 SIQGVSTNN----------TNSIVKSAPVLLSAPSSGSNSG--RLEISPPVLQNPNEFSDVRLVP 766

  Fly   707 -EDDDHHGAVDEDDDDTLSENN--GSS---------NELPAM----------------------S 737
             |:|.:.|. .:|.::.|..:|  |||         ||:|.:                      .
Yeast   767 IENDANMGQ-SKDGEEYLDGSNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRK 830

  Fly   738 LGYQQILQS--------SVYRNMDLITSTPALHLGRRSMSPITKSTQRMPKAMQESIMTPRSRKP 794
            .|.|.:::.        .|.:|    |.||.: |..:.::.:|...:|..:.:...|.|.:..:|
Yeast   831 SGSQLVIEEIEKQFSAWKVQQN----TETPNI-LTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEP 890

  Fly   795 VMLLTALAGNGDKQL-NLSFAEQDEPDSIGGTPTKQLEPPSLHSEDATSLGGYAD---------- 848
            :|.|.    ...|.: ||.|        :||..:.:.:....:....::|....:
Yeast   891 LMRLV----KSKKMMENLPF--------VGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVL 943

  Fly   849 -ILGQHQSFALFNPRERTTSSSNSNEDSKPSNALSSDFKEYLLTRSVLTASPADLSFASRSDDFG 912
             :|.:|        .|:.|..|:.|              ...|....|..:|..:.      ||.
Yeast   944 RVLSEH--------IEKVTRYSHWN--------------RMTLYNLALVFAPGLIR------DFS 980

  Fly   913 GASTTQDIDDLDESDLSPSLLYCLDGN 939
            |   .:||.|:.|.:...:.::   ||
Yeast   981 G---EKDIIDMKERNYIVAFIF---GN 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	52/267 (19%)
RGA1	NP_014770.1	LIM1_Rga	13..67	CDD:188780
		LIM2_Rga	70..123	CDD:188781	2/4 (50%)
		Smc	<569..>673	CDD:224117	23/132 (17%)
		RhoGAP	803..1002	CDD:214618	42/250 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900