DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP54D and Chn1

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_038961900.1	Gene:	Chn1 / 84030	RGDID:	620139	Length:	580	Species:	Rattus norvegicus

Alignment Length:	323	Identity:	77/323 - (23%)
Similarity:	122/323 - (37%)	Gaps:	59/323 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ANLNDFRDRDLATRMRRCNYEKYKSLVRMHLSFELELNTDEFDLPCHEIVYEDKGKLKK---WNR 71
            |.|.:..|...||.....:.::..||||.....|.|      .:|.:|.|:..|....:   |..
  Rat   283 AVLKETHDEKEATGQDGVSEKRLTSLVRRATLKENE------QIPKYEKVHNFKVHTFRGPHWCE 341

  Fly    72 LSKKHRLGHGAAATSCA-AG-----SASKSVGNSPTETLQQ-----QIDPGFLMHLQELKEFLML 125
            .......|..|....|| .|     ..||.|.|.....|:.     ..|...|:.....|..:::
  Rat   342 YCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHITKRPMVV 406

  Fly   126 E--------KNLTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSA--HDCATVFKG----F 176
            :        :.|..|||:|.:|......:::|....|.    |.|..|.  ::...:..|    :
  Rat   407 DMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG----EKADISVNMYEDINIITGALKLY 467

  Fly   177 LSELPEPLLTDAHYPAHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIE 241
            ..:||.||:|...||..::.|.:..            ....|.::...|..||..|.|.|::::.
  Rat   468 FRDLPIPLITYDAYPKFIESAKIVD------------PDEQLETLHEALRSLPPAHCETLRYLMA 520

  Fly   242 MLHAVAKHEKSNKMSADNLATLFTPHLICPRQLPPEV----LHYQAKKMSSIVTYMIVRGLDI 300
            .|..|..|||.|.|||:||..:|.|.|:...:|.|..    :.||     .:|..::::..||
  Rat   521 HLKRVTLHEKENLMSAENLGIVFGPTLMRSPELDPMAALNDIRYQ-----RLVVELLIKNEDI 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	51/212 (24%)
Chn1	XP_038961900.1	SH2_a2chimerin_b2chimerin	163..249	CDD:198215
		C1_alphaCHN	322..378	CDD:410406	13/55 (24%)
		RhoGAP_chimaerin	387..580	CDD:239837	51/213 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900