DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP54D and Gmip

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_030099716.1	Gene:	Gmip / 78816	MGIID:	1926066	Length:	1002	Species:	Mus musculus

Alignment Length:	464	Identity:	102/464 - (21%)
Similarity:	173/464 - (37%)	Gaps:	104/464 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 EFLMLEKNLTQE--------------------GLFRKAGAVSRQNELRMHIQHDKPLNLELAGFS 165
            :||.|.::..:|                    |::|.:|:..|...|....::.:.| :||:|.|
Mouse   563 DFLQLPRDFPEEVPFVITRCTAEIEHRALGLQGIYRVSGSRVRVERLCQAFENGRAL-VELSGNS 626

  Fly   166 AHDCATVFKGFLSELPEPLLTDAHYPAHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPE 230
            .||..:|.|.||.||.:|::....|.|.:.:|....|..|....|......::.|::.||:.||:
Mouse   627 PHDITSVLKRFLQELTDPVVPFHLYDAFISLAKTLHADPGDDPGTPNPSPEIIRSLKTLLVQLPD 691

  Fly   231 EHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLICPRQLP------PEVLHYQAKKMSSI 289
            .:...|:|::..|..||...:.|||||:||..:|.|.|:.|...|      |......:...:.:
Mouse   692 SNYSTLRHLVAHLFRVAARFEENKMSANNLGIVFGPTLLRPPDGPRATGASPVACLLDSGHQAQL 756

  Fly   290 VTYMIVRGLDIF---EVPGKLSTDIRAYFLERKRKKTMSPEQTLDESISDVSTVNTVYTFVDRAA 351
            |.::||....||   |:|                  ..|...|.|..::.....::    ....|
Mouse   757 VEFLIVHYEQIFGMDELP------------------LASEPLTQDPGLAPACLESS----PQHPA 799

  Fly   352 TAAATNTNNTDTEL-----AQLYAHIQSMPESSKKRRLIKQFNKQNGQGTP-----LQLVVMNRL 406
            :..|.:|......|     .:.::.::..||.:...   |..|:....|:.     |||..:.|.
Mouse   800 SLLAQDTQPLTIALDSSPDPKHHSALEKCPEVTPPE---KSLNRDFAIGSHVLGFFLQLATLQRD 861

  Fly   407 KNNEATRSAK--------------SLGDSIKKHIFHKSLMSRTPKR-----VPPSFHLASG---- 448
            :..|.....:              :||...:.|      .||.|.:     |.|..|..|.
Mouse   862 QREEEVEDTRDGAGDGSSHCPEDLALGAQSRGH------FSRQPVKYSRGGVRPVTHQLSSLALV 920

  Fly   449 -----SETP-NMSHVKPPKMRVLFQSPTPPTPTSSTITSVSLSTNTRH-QLQKSISSASLKIESS 506
                 .||| .:|.|....:||....|....|..|.:....|   .:| ::.:..:....|:.|.
Mouse   921 ASKLCEETPVTVSAVHRGSLRVRGLGPAAACPEGSPLRRNPL---PKHFEITQETARLLSKLNSD 982

  Fly   507 SSDSSSSCA 515
            :...::.||
Mouse   983 AVSRTTCCA 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	59/220 (27%)
Gmip	XP_030099716.1	BAR	124..324	CDD:386243
		C1	503..548	CDD:197519
		RhoGAP	560..763	CDD:383032	54/200 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810