DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP54D and Chn2

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_001157112.1	Gene:	Chn2 / 69993	MGIID:	1917243	Length:	468	Species:	Mus musculus

Alignment Length:	312	Identity:	74/312 - (23%)
Similarity:	120/312 - (38%)	Gaps:	77/312 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EKYKSLVRM--------HLSFELELNTDEFDLPCHEIVYEDKGKLKKWNRLSKKHRLG---HGAA 83
            ||..||||.        |.::|   .|..|.      |:..:|  ..|.........|   .|..
Mouse   191 EKISSLVRRAALTHNDNHFNYE---KTHNFK------VHTFRG--PHWCEYCANFMWGLIAQGVR 244

  Fly    84 ATSCAAG---SASKSVGNSPTETLQQ-----QIDPGFLMHLQELKEFLMLE--------KNLTQE 132
            .:.|...   ..||.|.|.....|::     ..|...|:.....:..::::        :.|..|
Mouse   245 CSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSE 309

  Fly   133 GLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSAHDCATV------FKGFLSELPEPLLTDAHYP 191
            ||:|.:|......:::|....|.    |.|..||:....:      .|.:..:||.|::|...|.
Mouse   310 GLYRVSGFTEHIEDVKMAFDRDG----EKADISANIYPDINIITGALKLYFRDLPIPIITYDTYS 370

  Fly   192 AHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIEMLHAVAKHEKSNKMS 256
            ..::.|.:..|        .||    |.:|..:|:|||..|.|.|::::..|..|..:||.|.|:
Mouse   371 KFIEAAKISNA--------DER----LEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNLMN 423

  Fly   257 ADNLATLFTPHLICPRQLPPE-----VLH---YQAKKMSSIVTYMIVRGLDI 300
            |:||..:|.|.|:    .|||     .||   ||     .::..:::...|:
Mouse   424 AENLGIVFGPTLM----RPPEDSTLTTLHDMRYQ-----KLIVQILIENEDV 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	53/216 (25%)
Chn2	NP_001157112.1	SH2_a2chimerin_b2chimerin	52..138	CDD:198215
		C1_1	215..267	CDD:278556	11/59 (19%)
		RhoGAP_chimaerin	275..468	CDD:239837	53/217 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900