DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP54D and Arhgap19

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_038957347.1	Gene:	Arhgap19 / 679082	RGDID:	1593044	Length:	536	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	119/401 - (29%)
Similarity:	199/401 - (49%)	Gaps:	37/401 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LMHLQELKEFLMLEKNLTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSAHDCATVFKGFL 177
            :..:.:|.|:  |.|||..|||||..|...||..||..:.:...::|:...|.::|.||:.|.||
  Rat   122 IAQIYQLIEY--LHKNLRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVATLLKMFL 184

  Fly   178 SELPEPLLTDAHYPAHLQIAPLCQALN-GQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIE 241
            .||||||||..|:..||:||.|.|..: |..|...::::. :.::|||.|:||..:|.||:.:::
  Rat   185 GELPEPLLTHKHFHVHLKIADLMQFDDKGNKTNIPDKERQ-IEALQLLFLILPPANRNLLKLLLD 248

  Fly   242 MLHAVAKHEKSNKMSADNLATLFTPHLICPRQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGK 306
            :|:..||.:..|||||.|||.:|.||::.|:.:....|.....|:::.:.:||.....:|:.|..
  Rat   249 LLYQTAKKQDKNKMSAHNLALMFAPHVLWPKNVTANDLQENITKLNTGMAFMIKHSQKLFKAPAY 313

  Fly   307 LSTDIRAYFLERKRKKTMSPEQTLDESIS---------DVSTVNTVYTFVDRAATAAATNTNNTD 362
            :....|.|:|   ..:|...:..||.:.|         .....|.|.::..:..|     ..:|:
  Rat   314 IRECARLYYL---GSRTQVSKDDLDLTTSCHAMSFQRARPQKQNRVDSYSQQEET-----QQHTE 370

  Fly   363 TELAQLYAHIQSMPESSKKRRLIKQFNKQNGQGTPLQLVVMNRLKNNEATRSAKSLGDSIKKHIF 427
            ..|.:|:.|:.::|:|:||::||:||:||:...||.:.....|::....:||...|   ||:.:.
  Rat   371 EALRELFQHVHNLPDSAKKKQLIRQFHKQSLTQTPGREPSTPRVQKRARSRSFSGL---IKRKVL 432

  Fly   428 HKSLMSRTPKRVPPSFHLASGSETPNMSHVKPPKMR--VLFQSPTPPTPTSSTITSVSLSTNTRH 490
            ...:.|......|       ..|:..|..:|.....  .||.|.:|    :.|:|.:.|..:...
  Rat   433 GSQMTSEKKNSSP-------APESVAMEELKKASKENMNLFFSGSP----AVTVTPMRLKWSEAK 486

  Fly   491 QLQKSISSASL 501
            :..|..|..||
  Rat   487 REGKKASKGSL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	71/200 (36%)
Arhgap19	XP_038957347.1	RhoGAP_ARHGAP19	113..320	CDD:239857	71/200 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346242
Domainoid	1	1.000	115	1.000	Domainoid score	I5884
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13159
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376367at33208
OrthoFinder	1	1.000	-	-		FOG0008267
OrthoInspector	1	1.000	-	-		oto98178
orthoMCL	1	0.900	-	-		OOG6_108071
Panther	1	1.100	-	-	LDO	PTHR14963
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.750