DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP54D and chn2

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_699642.6	Gene:	chn2 / 570999	ZFINID:	ZDB-GENE-091020-5	Length:	466	Species:	Danio rerio

Alignment Length:	317	Identity:	72/317 - (22%)
Similarity:	124/317 - (39%)	Gaps:	98/317 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RRCNYEKYKSLVRMH-----------LSF------------ELELNTDEFDLPCHEIV----YED 62
            :.|||||..:. ::|           .:|            :..||..:   .|.::|    ..|
Zfish   205 KHCNYEKIHNF-KVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHK---QCSKLVPSDCQPD 265

  Fly    63 KGKLKKWNRLSKKHRLGHGAAATSCAAGSASKSVGNSPTETLQQQIDPGFLMHLQELKEFLMLEK 127
            ..::||               ..||...:..|: .|:|...:   :|    |.::|::     .:
Zfish   266 LRRIKK---------------VFSCDLTTLVKA-HNTPRPMV---LD----MCIREIE-----HR 302

  Fly   128 NLTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSA------HDCATVFKGFLSELPEPLLT 186
            .|..|||:|.:|......::|:....|.    |.|..||      :..|...|.:|.:||.|::|
Zfish   303 GLKSEGLYRVSGFTEHIEDVRLSFDRDG----EKADISANIYPDINIIAGALKLYLRDLPIPVIT 363

  Fly   187 DAHYPAHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIEMLHAVAKHEK 251
            ...|...:|.|.:        |....|    |.:|...||.||..|.|.|::::..|..|..:||
Zfish   364 YDVYSRFIQAAKI--------TDPDSR----LEAVHDGLLQLPPAHYETLRYLMTHLKRVTMYEK 416

  Fly   252 SNKMSADNLATLFTPHLICPRQLPPEV--------LHYQAKKMSSIVTYMIVRGLDI 300
            .|.|:::||..:|.|.|:    .||::        :.||     .::..:::...||
Zfish   417 DNYMNSENLGIVFGPTLM----RPPDLNTLTTLNDMRYQ-----KLIVQLLIEHEDI 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	53/208 (25%)
chn2	XP_699642.6	SH2_a2chimerin_b2chimerin	52..138	CDD:198215
		C1_1	213..265	CDD:278556	6/55 (11%)
		RhoGAP_chimaerin	273..466	CDD:239837	58/230 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900