DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP54D and gmip

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_694162.5	Gene:	gmip / 565801	ZFINID:	ZDB-GENE-130530-823	Length:	1017	Species:	Danio rerio

Alignment Length:	697	Identity:	145/697 - (20%)
Similarity:	232/697 - (33%)	Gaps:	222/697 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RDRDLATRMRRCNYEKYKSLVRMHLSFELELNTDEFDLPCHEIVYEDKGKLKKWNRLSKKHRLGH 80
            |.|.:.::|.:|.......||.       .:..:|..|..|.       |..:..:|..:||.|.
Zfish   497 RLRKMKSKMVKCKQCDNYILVN-------GIECEECGLAVHR-------KCLEVCQLECEHRRGF 547

  Fly    81 GAAATSCAAGSASKSVGNSPTETLQQQIDPGFLMHLQELKEFLMLEKNLTQEGLFRKAGAVSRQN 145
                   ..|:...|:   |.||  |...|..::...|..|    .:.|..:|::|.:|:..|..
Zfish   548 -------VFGTEFSSL---PRET--QDSVPFVVLRCTEEIE----NRALGVQGVYRISGSKPRVL 596

  Fly   146 EL--RMHIQHDKPLNLELAGFSAHDCATVFKGFLSELPEPLLTDAHYPAHLQIAPLCQALNGQTT 208
            :|  ...||.|:   ::|:..|.||..:|.|.|..||||||||...|...:.:....|.|:.:..
Zfish   597 KLCQAFEIQKDQ---VDLSDLSPHDITSVLKHFFKELPEPLLTFDLYNDFIAVGKEIQRLSEKDH 658

  Fly   209 ATAERQ---QHLLNSVQLLLLLLPEEHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLIC 270
            | ||..   ::::..::.|:..||..:...:||::..|:.||:..:.||||..||..:|.|.|:.
Zfish   659 A-AESPGIVENIVRRLRELIGRLPVCNNITVQHMMAHLNRVAEQFEDNKMSPGNLGIVFGPTLLR 722

  Fly   271 PRQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGKLSTDIRAYFLERKRKKTMSPEQTLDESIS 335
            |                      :|.|                                   .:|
Zfish   723 P----------------------LVSG-----------------------------------DVS 730

  Fly   336 DVSTVNTVYTFVDRAATAAATNTNNTDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQGTPLQL 400
            .::.:.|.|                                                 |...::.
Zfish   731 MIALLETSY-------------------------------------------------QALLVEF 746

  Fly   401 VVMNRLKNNEATRSAKSLGDSIKKHIFHKSLMSRTPKRVPPSFHLASGSETPNMSHVKPPKMRVL 465
            ::.|                  ...:|..:..|.||...||:..|   .|||
Zfish   747 MISN------------------YDQVFGSATRSGTPPPPPPTAPL---PETP------------- 777

  Fly   466 FQSPTPPTPTSSTITSVSLSTNTRHQLQKSISSASLKIESSS---SDSSSSCATSGSISAPVSRQ 527
               |....|.|.:.:|....|.|..:..:|:.:.::|.:||.   ||.|||......:|...:.:
Zfish   778 ---PRATCPVSPSSSSSQDPTATSRERPRSLENRTIKRDSSEGYISDKSSSNEAMDQLSPEANER 839

  Fly   528 -----QSKESPSGNGAAGASGQELDEIDADCCVTPLKIM---SAVAK------QLIDKKSVAWDE 578
                 .:..||.|.....|..|............|:|..   ||.|:      ||.|:......|
Zfish   840 AVLAMSATASPQGLPGQAAENQLQTRSRTHLSRQPVKYYRQGSAGAQSRKTSAQLRDENISVSGE 904

  Fly   579 HRLLEIEEYSNPSTPVQQSTRYKSEPNLSSILPQVDAEEEDDGALTPI---VEGRSTMVASSSHM 640
            ..:....:.|..|:|....|....:   .:::|| |..|...||...:   |...|....:||.
Zfish   905 GLVSGSADSSRSSSPEPLKTLLCLQ---ETVVPQ-DKTESQTGAHAGVQRTVSQESVQAGASSF- 964

  Fly   641 GRSITRKLMKGVSMGNLRFPFSTPETTKRLVRSVSATLRRRPSGEES 687
                       |..||.....:|....:||:||    ||||...|::
Zfish   965 -----------VREGNTNQSNNTLRGRERLIRS----LRRRSVEEKT 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	53/210 (25%)
gmip	XP_694162.5	BAR	129..337	CDD:299863
		C1	499..541	CDD:197519	10/55 (18%)
		RhoGAP	549..750	CDD:295372	63/319 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900