Protein Alignment RhoGAP54D and gmip

DIOPT Version :10

• Sequence 1: NP_611236.2
• Gene: RhoGAP54D / 36996
• FlyBaseID: FBgn0034249
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: XP_694162.5
• Gene: gmip / 565801
• ZFINID: ZDB-GENE-130530-823
• Length: 1017
• Species: Danio rerio
• Alignment Length: 697
• Identity: 145/697 - (20%)
• Similarity: 232/697 - (33%)
• Gaps: 222/697 - (31%)

  Fly    16 RDRDLATRMRRCNYEKYKSLVRMHLSFELELNTDEFDLPCHEIVYEDKGKLKKWNRLSKKHRLGH 80
            |.|.:.::|.:|.......||.       .:..:|..|..|.       |..:..:|..:||.|.
Zfish   497 RLRKMKSKMVKCKQCDNYILVN-------GIECEECGLAVHR-------KCLEVCQLECEHRRGF 547

  Fly    81 GAAATSCAAGSASKSVGNSPTETLQQQIDPGFLMHLQELKEFLMLEKNLTQEGLFRKAGAVSRQN 145
                   ..|:...|:   |.||  |...|..::...|..|    .:.|..:|::|.:|:..|..
Zfish   548 -------VFGTEFSSL---PRET--QDSVPFVVLRCTEEIE----NRALGVQGVYRISGSKPRVL 596

  Fly   146 EL--RMHIQHDKPLNLELAGFSAHDCATVFKGFLSELPEPLLTDAHYPAHLQIAPLCQALNGQTT 208
            :|  ...||.|:   ::|:..|.||..:|.|.|..||||||||...|...:.:....|.|:.:..
Zfish   597 KLCQAFEIQKDQ---VDLSDLSPHDITSVLKHFFKELPEPLLTFDLYNDFIAVGKEIQRLSEKDH 658

  Fly   209 ATAERQ---QHLLNSVQLLLLLLPEEHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLIC 270
            | ||..   ::::..::.|:..||..:...:||::..|:.||:..:.||||..||..:|.|.|:.
Zfish   659 A-AESPGIVENIVRRLRELIGRLPVCNNITVQHMMAHLNRVAEQFEDNKMSPGNLGIVFGPTLLR 722

  Fly   271 PRQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGKLSTDIRAYFLERKRKKTMSPEQTLDESIS 335
            |                      :|.|                                   .:|
Zfish   723 P----------------------LVSG-----------------------------------DVS 730

  Fly   336 DVSTVNTVYTFVDRAATAAATNTNNTDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQGTPLQL 400
            .::.:.|.|                                                 |...::.
Zfish   731 MIALLETSY-------------------------------------------------QALLVEF 746

  Fly   401 VVMNRLKNNEATRSAKSLGDSIKKHIFHKSLMSRTPKRVPPSFHLASGSETPNMSHVKPPKMRVL 465
            ::.|                  ...:|..:..|.||...||:..|   .|||
Zfish   747 MISN------------------YDQVFGSATRSGTPPPPPPTAPL---PETP------------- 777

  Fly   466 FQSPTPPTPTSSTITSVSLSTNTRHQLQKSISSASLKIESSS---SDSSSSCATSGSISAPVSRQ 527
               |....|.|.:.:|....|.|..:..:|:.:.::|.:||.   ||.|||......:|...:.:
Zfish   778 ---PRATCPVSPSSSSSQDPTATSRERPRSLENRTIKRDSSEGYISDKSSSNEAMDQLSPEANER 839

  Fly   528 -----QSKESPSGNGAAGASGQELDEIDADCCVTPLKIM---SAVAK------QLIDKKSVAWDE 578
                 .:..||.|.....|..|............|:|..   ||.|:      ||.|:......|
Zfish   840 AVLAMSATASPQGLPGQAAENQLQTRSRTHLSRQPVKYYRQGSAGAQSRKTSAQLRDENISVSGE 904

  Fly   579 HRLLEIEEYSNPSTPVQQSTRYKSEPNLSSILPQVDAEEEDDGALTPI---VEGRSTMVASSSHM 640
            ..:....:.|..|:|....|....:   .:::|| |..|...||...:   |...|....:||.
Zfish   905 GLVSGSADSSRSSSPEPLKTLLCLQ---ETVVPQ-DKTESQTGAHAGVQRTVSQESVQAGASSF- 964

  Fly   641 GRSITRKLMKGVSMGNLRFPFSTPETTKRLVRSVSATLRRRPSGEES 687
                       |..||.....:|....:||:||    ||||...|::
Zfish   965 -----------VREGNTNQSNNTLRGRERLIRS----LRRRSVEEKT 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_611236.2	RhoGAP	107..313	CDD:470621	53/210 (25%)
gmip	XP_694162.5	BAR	129..337	CDD:472257
		C1_GMIP-like	494..545	CDD:410366	12/61 (20%)
		RhoGAP	549..750	CDD:470621	63/319 (20%)