DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP54D and GMIP

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_057657.2	Gene:	GMIP / 51291	HGNCID:	24852	Length:	970	Species:	Homo sapiens

Alignment Length:	463	Identity:	104/463 - (22%)
Similarity:	170/463 - (36%)	Gaps:	125/463 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 EFLMLEKNLTQE--------------------GLFRKAGAVSRQNELRMHIQHDKPLNLELAGFS 165
            :||.|.::..:|                    |::|.:|:..|...|....::.:.| :||:|.|
Human   552 DFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRAL-VELSGNS 615

  Fly   166 AHDCATVFKGFLSELPEPLLTDAHYPAHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPE 230
            .||.::|.|.||.||.||::....|.|.:.:|....|..|....|......::.|::.||:.||:
Human   616 PHDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPEVIRSLKTLLVQLPD 680

  Fly   231 EHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLICPRQLP------PEVLHYQAKKMSSI 289
            .:...|:|::..|..||.....|||||:||..:|.|.|:.|...|      |......:...:.:
Human   681 SNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCLLDSGHQAQL 745

  Fly   290 VTYMIVRGLDIF-----------------EVPGKLSTDIRAYFLERKRKKTMSPEQTLDES---- 333
            |.::||....||                 ..||.|:|            .:..|...||..
Human   746 VEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPLTT------------SSQPPPPHLDPDSQPP 798

  Fly   334 --ISDVSTVNTVYTFVDRAATAAATNTNNTDTELAQLYAHIQSMPESSKKRRLIKQFNKQNG--- 393
              .||.......::.:::..||       |.||:        ..|:|. :|..:.:..|..|
Human   799 VLASDPGPDPQHHSTLEQHPTA-------TPTEI--------PTPQSD-QREDVAEDTKDGGGEV 847

  Fly   394 --QGTPLQLVVMNRLKNNEATRSAKSLGDSIKKHIFHKSLMSRTPKRVP-----PSFHLASG--- 448
              ||....|                 ||...:.|      .||.|.:.|     |..|..|.
Human   848 SSQGPEDSL-----------------LGTQSRGH------FSRQPVKYPRGGVRPVTHQLSSLAL 889

  Fly   449 ------SETPNMSHVKPPKMRVLFQSPTPPTPTSSTITSVSLSTNTRH-QLQKSISSASLKIESS 506
                  .||| ::.|....:|....||...:|..|.:....|   .:| ::.:..:....|::|.
Human   890 VASKLCEETP-ITSVPRGSLRGRGPSPAAASPEGSPLRRTPL---PKHFEITQETARLLSKLDSE 950

  Fly   507 SSDSSSSC 514
            :...::.|
Human   951 AVPRATCC 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	62/234 (26%)
GMIP	NP_057657.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..76
		BAR	93..164	CDD:325158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..263
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..478
		C1	492..537	CDD:197519
		RhoGAP_GMIP_PARG1	549..752	CDD:239843	55/200 (28%)
		Marek_A	760..>874	CDD:332932	28/164 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..878		29/166 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..932		10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810