Protein Alignment RhoGAP54D and MYO9A

DIOPT Version :9

• Sequence 1: NP_001261060.1
• Gene: RhoGAP54D / 36996
• FlyBaseID: FBgn0034249
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: XP_011519915.1
• Gene: MYO9A / 4649
• HGNCID: 7608
• Length: 2638
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 135/609 - (22%)
• Similarity: 222/609 - (36%)
• Gaps: 159/609 - (26%)

  Fly    12 LNDFRDRD-LATRM----RRCNYEKYKSLVRMHLSFELELNTDEFDLP-----CHEIVY-EDKG- 64
            :|:|:..| .||::    |:...:|...||..|.....:  ..::.:|     |..::: .|:.
Human  2037 MNEFKTSDCTATKVPKTERKKRRKKETDLVEEHNGHIFK--ATQYSIPTYCEYCSSLIWIMDRAS 2099

  Fly    65 --KLKKWNRLSKKHRLGHGAAATSCAAGSASKSVGNSPTETLQQQIDPGFLMHLQELKEF----- 122
              ||.|:            |....|...:.:|.......|...:|    |.:.|..|...
Human  2100 VCKLCKY------------ACHKKCCLKTTAKCSKKYDPELSSRQ----FGVELSRLTSEDRTVP 2148

  Fly   123 LMLEK--------NLTQEGLFRKAGAVSRQNELRMHIQHD-KPLNLELAGFSAHDCATVFKGFLS 178
            |::||        .|..||::||:|:.::..|||..:..| :.:||:  .::.|..|:|||.:|.
Human  2149 LVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLD--DYNIHVIASVFKQWLR 2211

  Fly   179 ELPEPLLTDAHYPAHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIEML 243
            :||.||:|...|...|:...|            :.::..:..|..::..|...|...|:.:|..|
Human  2212 DLPNPLMTFELYEEFLRAMGL------------QERKETIRGVYSVIDQLSRTHLNTLERLIFHL 2264

  Fly   244 HAVAKHEKSNKMSADNLATLFTPHLI-CPRQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGKL 307
            ..:|..|.:|:|||:.||.:|.|.:: ||....|........|.::.|..::|..::.::...|
Human  2265 VRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLK- 2328

  Fly   308 STDIRAY-FLERKRKKTM---------------------------------------SPEQTLDE 332
              ||.:. |.|.|.|..:                                       ||......
Human  2329 --DISSLEFAENKAKTRLSLIRRSMKPVLIAVRFMNITRNSVSGKGRIRRGNYPGPSSPVVVRLP 2391

  Fly   333 SISDVSTVNTVYTFVDRAATAAATNTNNTDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQGTP 397
            |:||||.        :...:.||..|:.|:.:.|.:....:.:.|.      |:...|:..:.|.
Human  2392 SVSDVSE--------ETLTSEAAMETDITEQQQAAMQQEERVLTEQ------IENLQKEKEELTF 2442

  Fly   398 LQLVVMNRLKNNEATRSAKSLGDSIKKHIFHKSLMSRTPKRVPPSFHLASGSETPNMSH---VKP 459
            ..||:..|..::|...|..|:|                         .|..||..||..   :..
Human  2443 EMLVLEPRASDDETLESEASIG-------------------------TADSSENLNMESEYAISE 2482

  Fly   460 PKMRVLFQSPTPPTPTSSTITSVSLSTNTRHQLQKSISSASLKIESSSSDSSSSCATSGSISAPV 524
            ...|.|..|      :..|......|:..|.||:|  ...||.:..||..|.....|:.|.....
Human  2483 KSERSLALS------SLKTAGKSEPSSKLRKQLKK--QQDSLDVVDSSVSSLCLSNTASSHGTRK 2539

  Fly   525 SRQQSKESP-----SGNGAAGASG 543
            ..|...:||     |||.|.|..|
Human  2540 LFQIYSKSPFYRAASGNEALGMEG 2563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	58/220 (26%)
MYO9A	XP_011519915.1	UBQ	6..110	CDD:294102
		MYSc	143..1014	CDD:214580
		MYSc_Myo9	160..1004	CDD:276836
		C1	2072..2120	CDD:237996	8/61 (13%)
		RhoGAP_myosin_IX	2133..2318	CDD:239842	53/198 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900