DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP54D and RhoGAP5A

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	273	Identity:	71/273 - (26%)
Similarity:	116/273 - (42%)	Gaps:	55/273 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 FDLPCHEIVYEDKGKLKKWNRLSKKHRLGHGAAATSCAA------GSASKSV------------G 97
            ::.|.|..|:..||  ..|.........|..|....|.|      ...|:.|            |
  Fly   238 YEKPHHFKVHTFKG--LNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRG 300

  Fly    98 NSPTE-TLQQQIDP----GFLMH--LQELKEFLMLEKNLTQEGLFRKAGAVSRQNELRMHI--QH 153
            ...|: |...|::|    .|::.  ::|::     .:.:.|||::|.:|.......|::.:  :.
  Fly   301 VFGTDLTTMVQLEPHHQIPFVVRRCVEEVE-----ARGMLQEGIYRVSGFADEIEALKLALDREG 360

  Fly   154 DKPLNLELAGFSAHDCATVFKGFLSELPEPLLTDAHYPAHLQIAPLCQALNGQTTATAERQQHLL 218
            :|....|.|..:.:..|...|.:|..||.||:|...||:.:..        |:|...||::|.:.
  Fly   361 EKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAA--------GRTGKQAEQRQLMA 417

  Fly   219 NSVQLLLLLLPEEHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLICPRQ----LPPEVL 279
            .:|:    .||..|...||:::|.|..||.|...|||:..||||:|.|.||...|    |..|:.
  Fly   418 EAVR----RLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIF 478

  Fly   280 HYQAKKMSSIVTY 292
                 .:||::|:
  Fly   479 -----MLSSLITH 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	56/198 (28%)
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	11/53 (21%)
		RhoGAP_chimaerin	302..491	CDD:239837	58/207 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900