Protein Alignment RhoGAP54D and Arhgap29

DIOPT Version :10

• Sequence 1: NP_611236.2
• Gene: RhoGAP54D / 36996
• FlyBaseID: FBgn0034249
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: NP_001426550.1
• Gene: Arhgap29 / 310833
• RGDID: 1306185
• Length: 1271
• Species: Rattus norvegicus
• Alignment Length: 830
• Identity: 168/830 - (20%)
• Similarity: 267/830 - (32%)
• Gaps: 284/830 - (34%)

  Fly     4 TMDTDHANLNDFRDRDLATRMRRCNYEKYKSLVRMHLSFELELNTDEFDLPCHEIVYED------ 62
            |:.:..|..:.||.....|:.|.|     :.:| |....|.|    |..|.||....|:
  Rat   606 TLMSKAALTHKFRKLRSPTKCRDC-----EGIV-MFPGVECE----ECLLVCHRKCLENLVIVCG 660

  Fly    63 ----KGKL----KKWNRLSKKHRLGHGAAATSCAAGSASKSV---------GNS-PTETLQQQID 109
                :||:    .::.:::||...|.......||:...|:::         ||. .||.|.|.::
  Rat   661 HQKLQGKMHIFGAEFIQVAKKEPDGIPFVLKICASEIESRALCLQGIYRVCGNKIKTEKLCQALE 725

  Fly   110 PGFLMHLQELKEFLMLEKNLTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSAHDCATVFK 174
            .|  |||.::.|                                          ||:||...|.|
  Rat   726 NG--MHLVDISE------------------------------------------FSSHDICDVLK 746

  Fly   175 GFLSELPEPLLTDAHYPAHLQIAPLCQALNGQTTA---TAERQQHLLNSVQL---------LLLL 227
            .:|.:||||.:....|...:.:|...|.:|.:..|   :.|.::|...|:::         ||..
  Rat   747 LYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQEAKKDSPEDKKHPHVSIEINRILLRSKDLLRQ 811

  Fly   228 LPEEHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLICPRQLPPEVLHYQAKKMSS---I 289
            ||..:...|.::|..|..|..|.:.|||::.||..:|.|.||.||.....|......:.||   :
  Rat   812 LPASNFNSLHYLIVHLKRVVDHAEENKMNSKNLGVIFGPTLIRPRPTTAPVTISSLAEYSSQARV 876

  Fly   290 VTYMIVRGLDIFEVPGKLSTDIRAYFLERKRKKTMSPEQTLDESISDVSTVNTVYTFVDRAA--- 351
            |.::|.....||:                   .::.|:..:      ::....:...||...
  Rat   877 VEFLITYAQKIFD-------------------GSLQPQAGV------IANTGAIAPQVDHGCHPK 916

  Fly   352 TAAATNTNNTDTELAQLY----AHIQSMPESSKKRRLIKQFNKQNGQGTPLQLVVMNRLKNNEAT 412
            ...:.:..::|..|.||:    ..|::|...||...|...|                    .|:.
  Rat   917 PLLSPDERDSDHSLKQLFFSSKEDIRTMDCESKTFELTTSF--------------------EESE 961

  Fly   413 RSAKSLGDSIKKHIFHKSLMSRTPKRVPPSFHLASGSETPNMSH-----VKPPKMRVL------- 465
            |...:||......:.:|             .||....|..:.||     .|.||:.:|
  Rat   962 RKQNALGKCDAPILDNK-------------VHLLFDQELESASHKTEDTCKSPKLLLLRSDRVAN 1013

  Fly   466 -FQSPTPPTPTSSTITSVSLSTNTRHQLQKSISSASLKIESSSSDSSSSCATSGSISAPVSRQQS 529
             .|.|||.|    .:..|||      .:.:.:..|....|.||.::.:                :
  Rat  1014 SVQRPTPRT----RLRPVSL------PVDRLLLLAGSPTERSSRNTGN----------------T 1052

  Fly   530 KESPSGNGAAGASGQELDEIDADCCVTPLKIMSAVAKQLIDKKSVAWDEHRLLEIEEYSNPSTPV 594
            .....|..||.......|..:..|     ..::...:|.:.|   :||
  Rat  1053 DSDKFGKNAAFEGLHRKDNSNTTC-----SKVNGFDQQNVQK---SWD----------------- 1092

  Fly   595 QQSTRYKSEPNLSSILPQVDAEE-----------EDDGA-------LTPIVEGRSTMVASSSHMG 641
            :|:.|.......:.|:|...||:           ...||       ..|....|.|...|||.
  Rat  1093 KQNERNSFTAKTTVIIPSAYAEKGLAVSTGNNRGHSSGAAQPSKAHADPARSARDTSEHSSSD-- 1155

  Fly   642 RSITRKLMKGVSMGNLRFPFSTPETTKRLVRSVS----ATLRRRPS------GEESKPC-PLAAD 695
                                |.|....|..|::.    .|..:.|:      |.|.|.. |.||.
  Rat  1156 --------------------SCPVAAVRAPRTLQPQHWTTFYKPPNPTFNVRGTEEKTAFPSAAV 1200

  Fly   696 APLLEDVDDSDEDDDHHGAVDEDDDDTLS---ENNG---SSNELPAMSLG 739
            .|:|.....|     |....|.|.:.||:   :.:|   .|:|.|.:..|
  Rat  1201 PPVLVHAPQS-----HVAKSDPDLEATLACPVQTSGQPKESSEEPGLPEG 1245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_611236.2	RhoGAP	107..313	CDD:470621	51/220 (23%)
Arhgap29	NP_001426550.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..601
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1038..1059		4/36 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1119..1158		9/60 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1227..1253		5/19 (26%)
		Interaction with PTPN13/PTPL1. /evidence=ECO:0000250	1268..1271