DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP54D and Myo9a

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_006511271.1	Gene:	Myo9a / 270163	MGIID:	107735	Length:	2633	Species:	Mus musculus

Alignment Length:	657	Identity:	137/657 - (20%)
Similarity:	239/657 - (36%)	Gaps:	188/657 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LNDFRDRD------LATRMRRCNYEKYKSLVRMHLSFELELNTDEFDLP-----CHEIVY-EDKG 64
            :|:|:..|      |.|. |:...:|...||..|.....:  ..::.:|     |..::: .|:.
Mouse  2040 MNEFKTLDSTAPKVLKTE-RKKRRKKETDLVEEHNGHIFK--ATQYSIPTYCEYCSSLIWIMDRA 2101

  Fly    65 ---KLKKWNRLSKKHRLGHGAAATSCAAGSASKSVGNSPTETLQQQIDPGFLMHLQELKEF---- 122
               ||.|:            |....|...:.:|.......|...:|    |.:.|..|...
Mouse  2102 SVCKLCKY------------ACHKKCCLKTTAKCSKKYDPELSSRQ----FGVELSRLTSEDRAV 2150

  Fly   123 -LMLEK--------NLTQEGLFRKAGAVSRQNELRMHIQHD-KPLNLELAGFSAHDCATVFKGFL 177
             |::||        .|..||::||:|:.::..|||..:..| :.:||:  .::.|..|:|||.:|
Mouse  2151 PLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLD--DYNIHVIASVFKQWL 2213

  Fly   178 SELPEPLLTDAHYPAHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIEM 242
            .:||.||:|...|...|:...|            :.::..:..|..::..|...|...|:.:|..
Mouse  2214 RDLPNPLMTFELYEEFLRAMGL------------QERKETIRGVYSVIDQLSRTHLNTLERLIFH 2266

  Fly   243 LHAVAKHEKSNKMSADNLATLFTPHLI-CPRQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGK 306
            |..:|..|.:|:|||:.||.:|.|.:: ||....|........|.::.|..::|..::.::...|
Mouse  2267 LVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLK 2331

  Fly   307 LSTDIRAY-FLERKRKKTM---------------------------------------SPEQTLD 331
               ||.:. |.|.|.|..:                                       ||.....
Mouse  2332 ---DISSLEFAENKAKTRLSLIRRSMKPVLIAVRFMSITRSSVSGKGRIHRGNYPSPSSPVIVRL 2393

  Fly   332 ESISDVSTVNTVYTFVDRAATAAATNTNNTDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQGT 396
            .|:|||..        :..::..|..|:.||.:.|.:....:.:.|.      |:...|:..:.|
Mouse  2394 PSMSDVPE--------ETLSSETAMETDLTDQQQAAMQQEEKVLTEQ------IENLQKEKEELT 2444

  Fly   397 PLQLVVMNRLKNNEATRSAKSLG----------DSIKKHIFHKSLMSRTPKRVPPSFHLASGSET 451
            ...||:..|..::|...|..|:|          ||.::.:...||.             |:|...
Mouse  2445 FEMLVLEPRASDDETLESEASIGTADSSENLNMDSEERSLALSSLK-------------AAGKSE 2496

  Fly   452 PNMSHVKPPKMRVLFQSPTPPTPTSSTITSVSLSTNTRHQLQKSISSASLKIESSSSDSSSSCAT 516
            |:....|.     |.:.|......||:::|...:|.:.|..:|.....|   :|....::|:|..
Mouse  2497 PSSKSRKQ-----LRKQPDSLDSVSSSVSSCLSNTTSSHGTRKRFQIYS---KSPFYRAASACEA 2553

  Fly   517 SGSISAPV--------------------------------SRQQSKESPSGNGAAGASGQELDEI 549
            .|: ..|:                                |.|::||:|.|...:|..    ..:
Mouse  2554 QGT-EGPLGQAKSLEDRPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGTVTSGRK----KTV 2613

  Fly   550 DADCCVT 556
            |:||..|
Mouse  2614 DSDCSST 2620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	58/220 (26%)
Myo9a	XP_006511271.1	RA_Myosin-IXa	15..110	CDD:340736
		MYSc_Myo9	160..1006	CDD:276836
		DUF5401	<968..>1283	CDD:375164
		IQ	1117..1138	CDD:197470
		PEHE	<1827..1891	CDD:373705
		C1	2075..2123	CDD:237996	8/61 (13%)
		RhoGAP_myosin_IX	2136..2321	CDD:239842	53/198 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900