DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP54D and Myo9b

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_038950134.1	Gene:	Myo9b / 25486	RGDID:	3146	Length:	2156	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	112/476 - (23%)
Similarity:	185/476 - (38%)	Gaps:	99/476 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GH-GAAATSCAAGSASKSVGNSPTETLQQQIDPGFLMHLQELKEFLMLEKNLTQEGLFRKAGAVS 142
            || |....|..:..||..:   ..|.|.:.::    ||            .|..|||:||:||.:
  Rat  1694 GHFGVCVDSLTSDKASVPI---VLEKLLEHVE----MH------------GLYTEGLYRKSGAAN 1739

  Fly   143 RQNELRMHIQHDKPLNLELAGFSAHDCATVFKGFLSELPEPLLTDAHYPAHLQIAPLCQALNGQT 207
            |..|||..:|.| |..::|..|..|....|.|.:|.||||||:|.|.|...|:...|
  Rat  1740 RTRELRQALQTD-PATVKLEDFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVEL-------- 1795

  Fly   208 TATAERQQHLLNSVQLLLLLLPEEHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLI-CP 271
               .|:|:.|. ::..:|..|||.:...|:.:|..|..||..|..|:||...||.:|.|.|: ||
  Rat  1796 ---PEKQEQLA-AIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCP 1856

  Fly   272 RQLPPEVLHYQAKKMSSIVTYMI--------VRGLDIFEVPGKLSTDIRAYFLERKRK------- 321
            ....|........|:::.|..:|        |:..:|..:....|...|...|.|:..
  Rat  1857 DNSDPLTSMKDVLKITTCVEMLIKEQMRKYKVKMEEINHLEAAESIAFRRLSLLRQNAPWPLKLG 1921

  Fly   322 --------KTMSPEQTLDESISDVSTVNTVYTFVDRAATAAATNTNNTDTELAQLYAHIQSMPES 378
                    :|.||...:.:.:.::..:      .:.||      ..:.|.|...|...|||:.|
  Rat  1922 FSSPYEGVRTKSPRTPVVQDLEELGAL------PEEAA------GGDEDREKEILMERIQSIKE- 1973

  Fly   379 SKKRRLIKQFNKQNGQGTPLQLVVMNRLKNNEATRSAKSLGDSIKKHIFHKSLMSRTPKRVPPSF 443
             :|..:..:..:.:.:|:..:.:      ::|.:.|.:||            |..|..:..
  Rat  1974 -EKEDITYRLPELDPRGSDEENL------DSETSASTESL------------LEERAVRGA---- 2015

  Fly   444 HLASGSETPNMSHVKPPKMRVLFQSPTPPTPTSSTITSVSLSTNTRHQLQKSISSASLKIESSSS 508
              |.|...|.:.....|....|..:..||....::..:|.:.|..|..:   :..|::|:.....
  Rat  2016 --AEGPPAPALPCPISPTPNPLPAATAPPRGRPTSFVTVRVKTPRRTPI---MPMANIKLPPGLP 2075

  Fly   509 DSSSSCATS-GSISAPVSRQQ 528
            ...:|.|.: ...:.||.|::
  Rat  2076 LHLTSWAPALQEAAVPVKRRE 2096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	64/214 (30%)
Myo9b	XP_038950134.1	Ubiquitin_like_fold	16..112	CDD:421700
		MYSc_Myo9	160..977	CDD:276836
		IQ	1014..1033	CDD:197470
		IQ	1036..1058	CDD:197470
		PTZ00449	<1145..1493	CDD:185628
		C1_Myosin-IXb	1626..1683	CDD:410434
		RhoGAP	1696..1881	CDD:413382	67/216 (31%)
		MCP_Sipho	1941..>2064	CDD:411416	27/163 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810