DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP54D and ARHGAP45

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_011526160.1	Gene:	ARHGAP45 / 23526	HGNCID:	17102	Length:	1168	Species:	Homo sapiens

Alignment Length:	384	Identity:	96/384 - (25%)
Similarity:	155/384 - (40%)	Gaps:	98/384 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 LTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSAHDCATVFKGFLSELPEPLLTDAHYPAH 193
            |..:|::|..|..:|..:|....::.|.| :||:..|.||.:.|.|.:|.:|||||::...|  |
Human   822 LRTKGIYRVNGVKTRVEKLCQAFENGKEL-VELSQASPHDISNVLKLYLRQLPEPLISFRLY--H 883

  Fly   194 LQIAPLCQALNGQTTATAE---RQQ---------HLLNSVQLLLLLLPEEHRELLQHIIEMLHAV 246
            ..:.....:|..:..|.|.   ||.         .|...::.||..||.|:|..||:::..|..:
Human   884 ELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRI 948

  Fly   247 AKHEKSNKMSADNLATLFTPHLICPRQLPPEVLHYQAKKMSSIVTY---------MIVR-GLDIF 301
            .:.|:.|||:..||..:|.|.|:.||  |.|.    ...:||:|.|         :||. || :|
Human   949 VEVEQDNKMTPGNLGIVFGPTLLRPR--PTEA----TVSLSSLVDYPHQARVIETLIVHYGL-VF 1006

  Fly   302 EVPGKLSTDIRAYFLERKRKKTMSPEQT---LDESISDVSTV-----------NTVYTFVDRAAT 352
            |                     ..||:|   .|||.:..:.|           ..||...:.||.
Human  1007 E---------------------EEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAAD 1050

  Fly   353 AAATN---TNNTDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQGTPLQLVVMNRLKNNEATR- 413
            ....:   :|::|::|.:. :.:.|..|:|....|  .|.:|......|::...:...:.|...
Human  1051 GCRESRVVSNDSDSDLEEA-SELLSSSEASALGHL--SFLEQQQSEASLEVASGSHSGSEEQLEA 1112

  Fly   414 SAKSLGDSIKKHIFHKSLMSRTPKRVPPSFHLASGSETPNMSHVKPPKMRVLFQSPTPP 472
            :|:..||..:.               .|:..| ||..|...::|        .|:|.||
Human  1113 TAREDGDGDED---------------GPAQQL-SGFNTNQSNNV--------LQAPLPP 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	61/205 (30%)
ARHGAP45	XP_011526160.1	FCH	285..360	CDD:214492
		C1	734..779	CDD:197519
		RhoGAP	791..1001	CDD:295372	56/187 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900