DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP54D and Arhgap29

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_001343453.1	Gene:	Arhgap29 / 214137	MGIID:	2443818	Length:	1266	Species:	Mus musculus

Alignment Length:	720	Identity:	141/720 - (19%)
Similarity:	255/720 - (35%)	Gaps:	218/720 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TMDTDHANLNDFRDRDLATRMRRCNYEKYKSLVRMHLSFELELNTDEFDLPCHEIVYED------ 62
            |:.:..|..:.||.....|:.|.|:.      :.|....|.|    |..|.||....|:
Mouse   606 TLMSKAALTHKFRKLRSPTKCRDCDG------IVMFPGVECE----ECLLVCHRKCLENLVIICG 660

  Fly    63 ----KGKL----KKWNRLSKKHRLGHGAAATSCAAGSASKSV---------GNS-PTETLQQQID 109
                :||:    .::.:::||...|.......||:...::::         ||. .||.|.|.::
Mouse   661 HQKLQGKMHIFGAEFIQVAKKEPDGIPFVLKICASEIENRALCLQGIYRVCGNKIKTEKLCQALE 725

  Fly   110 PGFLMHLQELKEFLMLEKNLTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSAHDCATVFK 174
            .|  |||.::.|                                          ||:||...|.|
Mouse   726 NG--MHLVDISE------------------------------------------FSSHDICDVLK 746

  Fly   175 GFLSELPEPLLTDAHYPAHLQIAPLCQALNGQTTA---TAERQQHLLNSVQL---------LLLL 227
            .:|.:||||.:....|...:.:|...|.:|.:..|   :.|.::|...|:::         ||..
Mouse   747 LYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQEAKKDSPEDKKHPHVSIEVNRILLKSKDLLRQ 811

  Fly   228 LPEEHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLICPRQLPPEVLHYQAKKMSS---I 289
            ||..|...|.::|..|..|..|.:.|||::.||..:|.|.||.||.....|......:.|:   :
Mouse   812 LPASHFNSLHYLIAHLRRVVDHAEENKMNSKNLGVIFGPTLIRPRPTTAPVTISSLAEYSNQARL 876

  Fly   290 VTYMIVRGLDIFEVPGKLSTDIRAYFLERKRKKTMSPEQTLDESISDVSTVNTVYTFVDRA---A 351
            |.::|.....||:                   .::.|:..:      :|....|...||:.   .
Mouse   877 VEFLITYSQKIFD-------------------GSLQPQAVV------ISNTGAVAPQVDQGYLPK 916

  Fly   352 TAAATNTNNTDTELAQLY----AHIQSMPESSKKRRLIKQF----NKQNGQG---TPLQLVVMNR 405
            ...:.:..:||..:..|:    ..|:|....||...|...|    .:||..|   .||....::.
Mouse   917 PLLSPDERDTDHSMKPLFFSSKEDIRSSDCESKSFELTTSFEESERRQNALGKCDAPLLDNKVHL 981

  Fly   406 LKNNEATRSAKSLGDSIKKHIFHKSLMSRTPKRVPPSFHLASGS---ETP--NMSHVKPPKMRVL 465
            |.:.|...:::.:.|           :.::||.:....:.|:.|   .||  .|..|..|..|:|
Mouse   982 LFDQEHESASQKMED-----------VCKSPKLLLLKSNRAANSVQRHTPRTKMRPVSLPVDRLL 1035

  Fly   466 FQSPTPPTPTSSTITSVSL----------------STNT---------RHQLQKS---------- 495
            ..:.:|...:|..:.:|..                ::||         :..:|||
Mouse  1036 LLASSPTERSSRDVGNVDSDKFGKNPAFEGLHRKDNSNTTRSKVNGFDQQNVQKSWDTQYVRNNF 1100

  Fly   496 ISSASLKIESSSSDSSSSCATSGSISAPVSRQQSKESPSGNGAAGASGQELDEIDADCCVTPLKI 560
            .:..::.:.|:..:...:..|..:...|.|:..::       .|.|:|...:...:|.|  |...
Mouse  1101 TAKTTMIVPSAYPEKGLTVNTGNNRDHPGSKAHAE-------PARAAGDVSERRSSDSC--PATA 1156

  Fly   561 MSAVAKQLIDKKSVAWDEHRLLEIEEYS------NPSTPVQQSTRYKSEPNLS--SIL---PQVD 614
            :.|               .|.|:.:.::      ||:..|:.:....:.|:::  .:|   ||:.
Mouse  1157 VRA---------------PRTLQPQHWTTFYKPPNPTFSVRGTEEKTALPSIAVPPVLVHAPQIH 1206

  Fly   615 AEEED 619
            ..:.|
Mouse  1207 VTKSD 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	51/220 (23%)
Arhgap29	NP_001343453.1	BAR	220..436	CDD:325158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..501
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..601
		C1	614..659	CDD:197519	13/54 (24%)
		RhoGAP	671..883	CDD:295372	60/255 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1039..1081		5/41 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1157		9/49 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1209..1266		1/3 (33%)
		Interaction with PTPN13/PTPL1. /evidence=ECO:0000250	1263..1266
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810