Protein Alignment RhoGAP54D and Arhgap29

DIOPT Version :10

• Sequence 1: NP_611236.2
• Gene: RhoGAP54D / 36996
• FlyBaseID: FBgn0034249
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: NP_766113.1
• Gene: Arhgap29 / 214137
• MGIID: 2443818
• Length: 1266
• Species: Mus musculus
• Alignment Length: 720
• Identity: 141/720 - (19%)
• Similarity: 255/720 - (35%)
• Gaps: 218/720 - (30%)

  Fly     4 TMDTDHANLNDFRDRDLATRMRRCNYEKYKSLVRMHLSFELELNTDEFDLPCHEIVYED------ 62
            |:.:..|..:.||.....|:.|.|:.      :.|....|.|    |..|.||....|:
Mouse   606 TLMSKAALTHKFRKLRSPTKCRDCDG------IVMFPGVECE----ECLLVCHRKCLENLVIICG 660

  Fly    63 ----KGKL----KKWNRLSKKHRLGHGAAATSCAAGSASKSV---------GNS-PTETLQQQID 109
                :||:    .::.:::||...|.......||:...::::         ||. .||.|.|.::
Mouse   661 HQKLQGKMHIFGAEFIQVAKKEPDGIPFVLKICASEIENRALCLQGIYRVCGNKIKTEKLCQALE 725

  Fly   110 PGFLMHLQELKEFLMLEKNLTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSAHDCATVFK 174
            .|  |||.::.|                                          ||:||...|.|
Mouse   726 NG--MHLVDISE------------------------------------------FSSHDICDVLK 746

  Fly   175 GFLSELPEPLLTDAHYPAHLQIAPLCQALNGQTTA---TAERQQHLLNSVQL---------LLLL 227
            .:|.:||||.:....|...:.:|...|.:|.:..|   :.|.::|...|:::         ||..
Mouse   747 LYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQEAKKDSPEDKKHPHVSIEVNRILLKSKDLLRQ 811

  Fly   228 LPEEHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLICPRQLPPEVLHYQAKKMSS---I 289
            ||..|...|.::|..|..|..|.:.|||::.||..:|.|.||.||.....|......:.|:   :
Mouse   812 LPASHFNSLHYLIAHLRRVVDHAEENKMNSKNLGVIFGPTLIRPRPTTAPVTISSLAEYSNQARL 876

  Fly   290 VTYMIVRGLDIFEVPGKLSTDIRAYFLERKRKKTMSPEQTLDESISDVSTVNTVYTFVDRA---A 351
            |.::|.....||:                   .::.|:..:      :|....|...||:.   .
Mouse   877 VEFLITYSQKIFD-------------------GSLQPQAVV------ISNTGAVAPQVDQGYLPK 916

  Fly   352 TAAATNTNNTDTELAQLY----AHIQSMPESSKKRRLIKQF----NKQNGQG---TPLQLVVMNR 405
            ...:.:..:||..:..|:    ..|:|....||...|...|    .:||..|   .||....::.
Mouse   917 PLLSPDERDTDHSMKPLFFSSKEDIRSSDCESKSFELTTSFEESERRQNALGKCDAPLLDNKVHL 981

  Fly   406 LKNNEATRSAKSLGDSIKKHIFHKSLMSRTPKRVPPSFHLASGS---ETP--NMSHVKPPKMRVL 465
            |.:.|...:::.:.|           :.::||.:....:.|:.|   .||  .|..|..|..|:|
Mouse   982 LFDQEHESASQKMED-----------VCKSPKLLLLKSNRAANSVQRHTPRTKMRPVSLPVDRLL 1035

  Fly   466 FQSPTPPTPTSSTITSVSL----------------STNT---------RHQLQKS---------- 495
            ..:.:|...:|..:.:|..                ::||         :..:|||
Mouse  1036 LLASSPTERSSRDVGNVDSDKFGKNPAFEGLHRKDNSNTTRSKVNGFDQQNVQKSWDTQYVRNNF 1100

  Fly   496 ISSASLKIESSSSDSSSSCATSGSISAPVSRQQSKESPSGNGAAGASGQELDEIDADCCVTPLKI 560
            .:..::.:.|:..:...:..|..:...|.|:..::       .|.|:|...:...:|.|  |...
Mouse  1101 TAKTTMIVPSAYPEKGLTVNTGNNRDHPGSKAHAE-------PARAAGDVSERRSSDSC--PATA 1156

  Fly   561 MSAVAKQLIDKKSVAWDEHRLLEIEEYS------NPSTPVQQSTRYKSEPNLS--SIL---PQVD 614
            :.|               .|.|:.:.::      ||:..|:.:....:.|:::  .:|   ||:.
Mouse  1157 VRA---------------PRTLQPQHWTTFYKPPNPTFSVRGTEEKTALPSIAVPPVLVHAPQIH 1206

  Fly   615 AEEED 619
            ..:.|
Mouse  1207 VTKSD 1211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_611236.2	RhoGAP	107..313	CDD:470621	51/220 (23%)
Arhgap29	NP_766113.1	BAR	220..436	CDD:472257
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..501
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..601
		C1_GMIP-like	613..663	CDD:410366	13/59 (22%)
		RhoGAP	671..883	CDD:470621	60/255 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1039..1081		5/41 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1116..1157		9/49 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1209..1266		1/3 (33%)
		Interaction with PTPN13/PTPL1. /evidence=ECO:0000250	1263..1266