DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP54D and Myo9b

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_006509629.1	Gene:	Myo9b / 17925	MGIID:	106624	Length:	2164	Species:	Mus musculus

Alignment Length:	435	Identity:	102/435 - (23%)
Similarity:	158/435 - (36%)	Gaps:	129/435 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GH-GAAATSCAAGSASKSVGNSPTETLQQQIDPGFLMHLQELKEFLMLEKNLTQEGLFRKAGAVS 142
            || |....|..:..||..:   ..|.|.:.::    ||            .|..|||:||:||.:
Mouse  1704 GHFGVCVDSLTSDKASVPI---VLEKLLEHVE----MH------------GLYTEGLYRKSGAAN 1749

  Fly   143 RQNELRMHIQHDKPLNLELAGFSAHDCATVFKGFLSELPEPLLTDAHYPAHLQIAPLCQALNGQT 207
            |..|||..:|.| |..::|..|..|....|.|.:|.||||||:|.|.|...|:...|
Mouse  1750 RTRELRQALQTD-PAAVKLEDFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVEL-------- 1805

  Fly   208 TATAERQQHLLNSVQLLLLLLPEEHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLI-CP 271
               .|:|:. |:::..:|..|||.:...|:.:|..|..||..|..|:||...||.:|.|.|: ||
Mouse  1806 ---PEKQEQ-LSAIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCP 1866

  Fly   272 RQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGKLSTDIRAYFLERKRKKTMSPEQTLDESISD 336
            ....|      ...|..::               |::|.:.....|:.||..|..|:
Mouse  1867 DNSDP------LTSMKDVL---------------KITTCVEMLIKEQMRKYKMKMEE-------- 1902

  Fly   337 VSTVNTVYTFVDRAATAAATNTNNTDTELAQLYAHIQSMPESSKKRRLIKQFNKQN-------GQ 394
               :|                             |::: .||...|||  ...:||       |.
Mouse  1903 ---IN-----------------------------HLEA-AESIAFRRL--SLLRQNAPWPLKLGF 1932

  Fly   395 GTPLQLV--------VMNRLKNNEATRSAKSLGDSIKKHIFHKSLMSRTPKRVPPSFHLAS---- 447
            .:|.:.|        |:..|:.......|....:..:|.|..:.:.|...::...::.|..
Mouse  1933 SSPYEGVRIKSPRTPVVQDLELGALPEEAAGGDEDREKEILMERIQSIKEEKEDITYRLPELDPR 1997

  Fly   448 GSETPNMSHVKPPKMRVLFQ------------SPTPPTPTSSTIT 480
            ||:..|:..........|.:            :|..|.|.|.|::
Mouse  1998 GSDEENLDSETSASTESLLEERGVRGAVEGPPAPALPCPISPTLS 2042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	61/206 (30%)
Myo9b	XP_006509629.1	RA_Myosin-IXb	16..112	CDD:340737
		MYSc_Myo9	160..977	CDD:276836
		IQ	1014..1035	CDD:197470
		IQ	1036..1058	CDD:197470
		DUF4045	1207..>1495	CDD:372533
		C1	1641..1689	CDD:237996
		RhoGAP_myosin_IXB	1706..1891	CDD:239872	67/237 (28%)
		PHA02682	<2029..>2123	CDD:177464	5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810