DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP54D and rga-3

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_504503.1	Gene:	rga-3 / 178961	WormBaseID:	WBGene00019600	Length:	1085	Species:	Caenorhabditis elegans

Alignment Length:	1011	Identity:	208/1011 - (20%)
Similarity:	359/1011 - (35%)	Gaps:	269/1011 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SKKHRLGHGAAATSCAAG----SASKSVGN--SPTETLQQQIDPGFL-MHLQELKEFLMLEKNLT 130
            |..:|.|...:.....||    ..|.::|.  |...||...:..|:. :.|:|:.:|::...|:.
Worm    12 SSVYRKGSTTSGVIAGAGPRPNKFSYTLGEVCSTNVTLDVNVGTGWTRIRLKEVPKFIVNAFNII 76

  Fly   131 Q------EGLFRKAGAVSRQNELRMHI----QHDKPLNLELAGFSAHDCATVFKGFLSELPEPLL 185
            .      :|:|||.|...|.|...:..    |.|.|.:     :|..|..|:.|.||.:|..|||
Worm    77 SKHGMDTDGIFRKEGNSVRLNRAEVQAIYKGQRDIPND-----YSVIDVCTMVKRFLRDLKPPLL 136

  Fly   186 TDAHYPAHLQIAPLCQA-LNGQTTATAERQQHLL----NSVQLLLLLLPEEHRELLQHIIEMLHA 245
            ......|.| :...||| ::.....|.:....:.    .:::....||.:.|...|.:::..|:.
Worm   137 DSEECRARL-LKKACQARISDGFLMTRDEMADVFYMEDRTIEQQTPLLSDAHASTLGYVMRQLNR 200

  Fly   246 VAKHEKSNKMSADNLATLF--------------TPHLICPRQLPPEVLHYQAKKM--SSIVTYMI 294
            :|.|.:.:|||.:|||.:|              ||.|  .|....::|..:..:|  ::....::
Worm   201 IAAHSEQHKMSIENLAIVFIGSVFGDGIHDSKKTPQL--RRGSKEDILAQKRHEMNVNTAAVKLL 263

  Fly   295 VRGLDIFEVPGKLSTDIRAYFLERKRKKTMSPEQTLDESISDVSTVNTVY-TFVDRAATAAATNT 358
            :...::..|               :|...::....|..|.:....:::.| |..|....:|.|
Worm   264 ITNANLIGV---------------RRDPYVTSNAMLRSSSAMPRCMSSGYETLSDADCLSAQT-- 311

  Fly   359 NNTDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQGTPLQLVVMNRLKNNEATR---SAKSLGD 420
                               :|.:||       :.|..|||.:    ..:::||..   :|:..|:
Worm   312 -------------------ASLQRR-------EPGPSTPLTI----HRRDSEAVHKIVTARKKGE 346

  Fly   421 SIKKHIFHKSLMSRTPKRVPPSF----HLASGSETPNMSHVKPPKMRVLFQSPTPPTPTSSTITS 481
            ...|.....|.:        |||    |..|     ||...|.|....|....|......:.|.|
Worm   347 QDSKKKRSASFL--------PSFRDLKHRFS-----NMKRTKSPSPERLTTGHTAEPSKLTDICS 398

  Fly   482 VSLSTNTRHQ----LQKSISSASLKIESSSSDSSSSCATSGSISAPVSRQQSKESPSGNGAAGAS 542
            ::|.|:. ||    .:|.::    :.||::..:.|:.:...|.|....|..:..:|..||:.
Worm   399 LNLHTDP-HQDPLIHRKKVA----RNESTTMSTGSTASGRQSRSHQNRRGNTNATPRNNGSG--- 455

  Fly   543 GQELDEIDADCCVTPLKIMSAVAKQLIDKKSVAWDEHRLLEIEEYSNPSTPVQQSTRYKSEPNLS 607
                                        |.::                      ||.::||..||
Worm   456 ----------------------------KSTI----------------------STMFESEQILS 470

  Fly   608 S-ILPQVDAEEEDDGAL---TPIVEGRSTMVAS---SSHMGRSITRKLMK--GVSMGNLRFPFST 663
            | .|.::.|.:.:..|:   ..|:......||.   |.|. |:...|:.|  .|.:|........
Worm   471 SGALRRLSASDRNTDAMRFAKQIMSNEQMNVAEFLLSEHQ-RNRESKIRKRNTVILGEKPRSNGV 534

  Fly   664 PETTKRLVRSVSATLRRRPSGEESKPCPLAADAPLLED--VDDSDEDDDHHGAVDEDDDDTL-SE 725
            ..|.:|....:|..|||      ::|..:.|..|...|  :::....::.....|.:.|||| :.
Worm   535 KLTNRRHTAPISNRLRR------NRPNTVGASLPHRNDSFLNNGSSMEEKENQADCETDDTLDAT 593

  Fly   726 NNGSSNELPAMSLGYQQILQSSVYRNMDLITSTPALHLGRRSM-----SPITKSTQRM---PKAM 782
            ||...:|.    |..|:.|::...|......:.|..|:...||     |...:||..:   |..|
Worm   594 NNVDQSEW----LLEQKALEARSRREGRKNKAAPMRHISTGSMLVLNGSMAVESTSMLKAEPLVM 654

  Fly   783 ----QESIMTPRSRKPVMLLTALAGNGDKQLNLSFAEQDEPDSIGGTPTKQLEPPSLHSEDATSL 843
                :||..:|:....|:|...|  :..|::. .|.:......:..||||      |..|:..:.
Worm   655 DSLKEESPQSPQKTPKVVLRKDL--DNLKKMK-KFCDIATSPMVMDTPTK------LSHENGHAW 710

  Fly   844 GGYADILGQHQSFALFNPRERTTSSSNSNEDS---KP-------SNALSSDFKEYLLTRS----- 893
            .|...::...::.:|...|.|...|.:...:|   ||       |:.:|...|...:|.:
Worm   711 VGTKQVVSVTRTPSLSRRRSRAHLSYSKATESPLDKPSEVRRESSSLMSPLLKHVTMTNNSAPSQ 775

  Fly   894 VLTASPADLSFASRSDDF-------------------------GGASTTQD-IDDLDESDLSPSL 932
            |:|:||. .:...||...                         |.:..:.| :||:....:|
Worm   776 VITSSPR-TNLTPRSHTLSPLAVKIKRSTPPPIPPHSPPHLTPGKSEVSLDALDDMKRISIS--- 836

  Fly   933 LYCLDGNEPTLASPFGNSNGRKRSAGTPLKSTLITN 968
                ||:.....||......:..|...|::|..|.|
Worm   837 ----DGSRRIPTSPSHPRMPKTFSPKLPIRSVSIDN 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	52/237 (22%)
rga-3	NP_504503.1	RhoGAP	63..232	CDD:214618	43/174 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900