DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP54D and Myo9a

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_599162.2	Gene:	Myo9a / 171296	RGDID:	621395	Length:	2626	Species:	Rattus norvegicus

Alignment Length:	651	Identity:	138/651 - (21%)
Similarity:	244/651 - (37%)	Gaps:	176/651 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LNDFRDRD------LATRMRRCNYEKYKSLVRMHLSFELELNTDEFDLP-----CHEIVY-EDKG 64
            :|:|:..|      |.|. |:...:|...||..|.....:  ..::.:|     |..::: .|:.
  Rat  2033 MNEFKTLDSTAPKVLKTE-RKKRRKKETDLVEEHNGHMFK--ATQYSIPTYCEYCSSLIWIMDRA 2094

  Fly    65 ---KLKKWNRLSKKHRLGHGAAATSCAAGSASKSVGNSPTETLQQQIDPGFLMHLQELKEF---- 122
               ||.|:            |....|...:.:|.......|...:|    |.:.|..|...
  Rat  2095 SVCKLCKY------------ACHKKCCLKTTAKCSKKYDPELSSRQ----FGVELSRLTSEDRAV 2143

  Fly   123 -LMLEK--------NLTQEGLFRKAGAVSRQNELRMHIQHD-KPLNLELAGFSAHDCATVFKGFL 177
             |::||        .|..||::||:|:.::..|||..:..| :.:||:  .::.|..|:|||.:|
  Rat  2144 PLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLD--DYNIHVIASVFKQWL 2206

  Fly   178 SELPEPLLTDAHYPAHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIEM 242
            .:||.||:|...|...|:...|            :.::..:..|..::..|...|...|:.:|..
  Rat  2207 RDLPNPLMTFELYEEFLRAMGL------------QERKETIRGVYSVIDQLSRTHLSTLERLIFH 2259

  Fly   243 LHAVAKHEKSNKMSADNLATLFTPHLI-CPRQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGK 306
            |..:|..|.:|:|||:.||.:|.|.:: ||....|........|.::.|..::|..::.::...|
  Rat  2260 LVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLK 2324

  Fly   307 LSTDIRAY-FLERKRKKTM---------------------------------------SPEQTLD 331
               ||.:. |.|.|.|..:                                       ||.....
  Rat  2325 ---DISSLEFAENKAKTRLSLIRRSMKPVLIAVRFMSITRSSVSGKGRLHRGSHPNPSSPVIVRL 2386

  Fly   332 ESISDVSTVNTVYTFVDRAATAAATNTNNTDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQGT 396
            .|:|||..        :...:..|.:|:.||.:.|.:....:.:.|.      |:...|:..:.|
  Rat  2387 PSMSDVPE--------ETLTSETAMDTDVTDQQQAAMQQEEKVLTEQ------IENLQKEKEELT 2437

  Fly   397 PLQLVVMNRLKNNEATRSAKSLG--DSIKKHIFHKSLMSRTP--KRVPPSFHLASGSETPNMSHV 457
            ...||:..|..::||..|..|:|  ||::.       ::..|  :.:..|...|:|...|:....
  Rat  2438 FEMLVLEPRASDDEALESEASIGTADSLEN-------LNMDPEERSLALSSLKAAGKSEPSSKFR 2495

  Fly   458 KPPKMRVLFQSPTPPTPTSSTITSVSLSTNTRHQLQKSISSASLKIESSSSDSSSSCATSGSISA 522
            |.     |.:.|......||:::|...:|.:.|..:|.....|   :|....::|:|...| :..
  Rat  2496 KQ-----LRKQPDSLDSVSSSVSSCLSNTTSSHGTRKRFQIYS---KSPFYRAASACEAQG-MEG 2551

  Fly   523 PV--------------------------------SRQQSKESPSGNGAAGASGQELDEIDADCCV 555
            |:                                |.|::||:|.|..::|..    ..:|:||..
  Rat  2552 PLGQAKSLEDRPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGTVSSGRK----KTVDSDCSS 2612

  Fly   556 T 556
            |
  Rat  2613 T 2613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	58/220 (26%)
Myo9a	NP_599162.2	Actin-binding. /evidence=ECO:0000250	908..919
		Neck or regulatory domain. /evidence=ECO:0000250	1022..1163
		Tail. /evidence=ECO:0000250	1164..2589		128/621 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1276
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1360..1397
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1562..1602
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1618..1673
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1689..1726
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1765..1784
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1872..1907
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2365..2385		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2449..2527		20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2552..2614		12/66 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900