DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP54D and myo9aa

DIOPT Version :9

Sequence 1:	NP_001261060.1	Gene:	RhoGAP54D / 36996	FlyBaseID:	FBgn0034249	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_021333664.1	Gene:	myo9aa / 100006612	ZFINID:	ZDB-GENE-080424-5	Length:	2590	Species:	Danio rerio

Alignment Length:	537	Identity:	117/537 - (21%)
Similarity:	204/537 - (37%)	Gaps:	120/537 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 LMLEK--------NLTQEGLFRKAGAVSRQNELRMHIQHD-KPLNLELAGFSAHDCATVFKGFLS 178
            |::||        .|..||::||:|:.::..||:..:..| ..:||:  .::.:..|:|||.:|.
Zfish  2112 LVVEKLVNYIEMHGLYTEGIYRKSGSTNKIKELKQGLDTDVNGVNLD--DYNINVIASVFKQWLR 2174

  Fly   179 ELPEPLLTDAHYPAHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIEML 243
            :||.||:|...|...|:...|            :.::.::..|..::..|...|...|:.:|..|
Zfish  2175 DLPNPLMTFELYEEFLRAMGL------------QDKKEVIRGVYSVIDQLSRTHLNTLERLIFHL 2227

  Fly   244 HAVAKHEKSNKMSADNLATLFTPHLI-CPRQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGKL 307
            ..:|..|::|:|||:.||.:|.|.:: ||..:.|........|.::.|..:|...::.:....|
Zfish  2228 VRIALQEETNRMSANALAIVFAPCILRCPDTIDPLRSVQDIGKTTACVELIICEQMNKYRARLK- 2291

  Fly   308 STDIRAY-FLERKRK-------KTMSPEQTLDESISDVSTVNTVYTFVDRAATAAATNTNNTDTE 364
              ||... |.|.|.|       ::|.|             |.....|:....:|||:.:......
Zfish  2292 --DINTLEFAENKAKSRLTFIRRSMKP-------------VIIAVRFMSITRSAAASGSMRKGKG 2341

  Fly   365 LAQLYAHIQSMPESSKKRRLIKQFNKQNGQGTP--------LQLVVMNRLKNNEATRSAKSLGDS 421
            ......:....|.:|.:.....:..:.:|:..|        .|.|.|.: :....|...:||...
Zfish  2342 PVHRLRYRTPSPPTSPRSPTAPEVMQDSGEEEPGRDPEVSEQQQVAMQQ-EEKVLTEQIESLQKE 2405

  Fly   422 IKKHIFHKSLMSRTPKRVPPSFHLASGSETPNMSHVKPPKMRVLFQSPTPPTPTSS---TITSVS 483
            .::..|  .:::..|:        ||..||             |....:..|..||   .:.|..
Zfish  2406 KEELTF--EMLALEPR--------ASDDET-------------LESEASIGTADSSENLNVDSEG 2447

  Fly   484 LSTN----------TRHQLQKSISSASLKIESSSSDSSSSCATSGSISA----PVSRQQS----K 530
            .:::          ||.:..:..|...|:.:..|.||..||:|..|:|:    |.||...    .
Zfish  2448 ATSDYSERGPALAATRPKKSEGKSRRVLRKQPESLDSIDSCSTVSSVSSSYMQPTSRTHKLSLRS 2512

  Fly   531 ESPSGNGAAGASGQELDEIDAD----------CCVTPLKIMSAVAKQLIDKKSVAWDEHRLLEIE 585
            :|||......:..:.||:.:.|          ....|.|     .||.:.....:...||    |
Zfish  2513 KSPSKRLYLSSPSESLDQPEQDGEERPQFTSRGTFNPEK-----GKQRLQGAKSSPQRHR----E 2568

  Fly   586 EYSNPSTPVQQSTRYKS 602
            :..:|....||...|.|
Zfish  2569 QKKDPELSPQQVVVYGS 2585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_001261060.1	RhoGAP	107..313	CDD:295372	52/199 (26%)
myo9aa	XP_021333664.1	UBQ	7..111	CDD:320785
		MYSc_Myo9	161..1039	CDD:276836
		IQ	1145..1166	CDD:197470
		Activator_LAG-3	<1464..1574	CDD:331748
		C1_1	2035..2083	CDD:278556
		RhoGAP	2096..2281	CDD:295372	49/182 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900