Protein Alignment RhoGAP54D and myo9aa

DIOPT Version :10

• Sequence 1: NP_611236.2
• Gene: RhoGAP54D / 36996
• FlyBaseID: FBgn0034249
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: XP_068078215.1
• Gene: myo9aa / 100006612
• ZFINID: ZDB-GENE-080424-5
• Length: 2584
• Species: Danio rerio
• Alignment Length: 525
• Identity: 116/525 - (22%)
• Similarity: 207/525 - (39%)
• Gaps: 102/525 - (19%)

  Fly   123 LMLEK--------NLTQEGLFRKAGAVSRQNELRMHIQHD-KPLNLELAGFSAHDCATVFKGFLS 178
            |::||        .|..||::||:|:.::..||:..:..| ..:||:  .::.:..|:|||.:|.
Zfish  2112 LVVEKLVNYIEMHGLYTEGIYRKSGSTNKIKELKQGLDTDVNGVNLD--DYNINVIASVFKQWLR 2174

  Fly   179 ELPEPLLTDAHYPAHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIEML 243
            :||.||:|...|...|:...|            :.::.::..|..::..|...|...|:.:|..|
Zfish  2175 DLPNPLMTFELYEEFLRAMGL------------QDKKEVIRGVYSVIDQLSRTHLNTLERLIFHL 2227

  Fly   244 HAVAKHEKSNKMSADNLATLFTPHLI-CPRQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGKL 307
            ..:|..|::|:|||:.||.:|.|.:: ||..:.|........|.::.|..:|...::.:....|
Zfish  2228 VRIALQEETNRMSANALAIVFAPCILRCPDTIDPLRSVQDIGKTTACVELIICEQMNKYRARLK- 2291

  Fly   308 STDI------------RAYFLERKRKKTMSPEQTLDESISDVSTVNTVYTFVDRAATAAATNTNN 360
              ||            |..|:.|..|..:...:.:..:.|..:....|:....|..:...:..:.
Zfish  2292 --DINTLEFAENKAKSRLTFIRRSMKPVIIAVRFMSITRSAAAGKGPVHRLRYRTPSPPTSPRSP 2354

  Fly   361 TDTELAQLYAHIQ--SMPESSKKRRL------------IKQFNKQNGQGTPLQLVVMNRLKNNEA 411
            |..|:.|.....:  ..||.|:::::            |:...|:..:.|...|.:..|..::|.
Zfish  2355 TAPEVMQDSGEEEPGRDPEVSEQQQVAMQQEEKVLTEQIESLQKEKEELTFEMLALEPRASDDET 2419

  Fly   412 TRSAKSLG--DSIKK-HIFHKSLMSRTPKRVPPSFHLASGSETPNMSHVKPPKMRVLFQSP--TP 471
            ..|..|:|  ||.:. ::..:...|...:|.|     |..:..|..|..|  ..|||.:.|  ..
Zfish  2420 LESEASIGTADSSENLNVDSEGATSDYSERGP-----ALAATRPKKSEGK--SRRVLRKQPESLD 2477

  Fly   472 PTPTSSTITSVSLS----TNTRHQLQKSISSASLKIESSSSDSSSSCATSGSISAPVSRQQSKES 532
            ...:.||::|||.|    |:..|:|.....|.|.::..||.                  .:|.:.
Zfish  2478 SIDSCSTVSSVSSSYMQPTSRTHKLSLRSKSPSKRLYLSSP------------------SESLDQ 2524

  Fly   533 PSGNGAAGASGQELDEIDADCCVTPLKIMSAVAKQLIDKKSVAWDEHRLLEIEEYSNPSTPVQQS 597
            |.      ..|:|..:..:.....|.|     .||.:.....:...||    |:..:|....||.
Zfish  2525 PE------QDGEERPQFTSRGTFNPEK-----GKQRLQGAKSSPQRHR----EQKKDPELSPQQV 2574

  Fly   598 TRYKS 602
            ..|.|
Zfish  2575 VVYGS 2579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP54D	NP_611236.2	RhoGAP	107..313	CDD:470621	52/211 (25%)
myo9aa	XP_068078215.1	RA_Myosin-IXa	16..111	CDD:340736
		MYSc_Myo9	161..1039	CDD:276836
		IQ	1145..1166	CDD:197470
		Activator_LAG-3	<1464..1574	CDD:151935
		C1_Myosin-IXa	2030..2087	CDD:410433
		RhoGAP	2096..2281	CDD:470621	49/182 (27%)