DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6484 and HXT4

DIOPT Version :9

Sequence 1:	NP_611234.1	Gene:	CG6484 / 36994	FlyBaseID:	FBgn0034247	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_011960.2	Gene:	HXT4 / 856492	SGDID:	S000001134	Length:	576	Species:	Saccharomyces cerevisiae

Alignment Length:	482	Identity:	126/482 - (26%)
Similarity:	221/482 - (45%)	Gaps:	55/482 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IAGLSASFGALCMGASIGWSSPVENMITVNTEY-----------GFPISSSQFGWVSSLLTLGAT 64
            |..|..:||    |...||.:...:.....|::           .:.:|..:.|.:.|:..:|..
Yeast    73 ICCLMVAFG----GFVFGWDTGTISGFVAQTDFIRRFGMKHHDGTYYLSKVRTGLIVSIFNIGCA 133

  Fly    65 VICIPIGFAIDWIGRRPTMLALIPPYMVGWVLMLFAKNVTMLYF-GRFILGMCGGAFCVTAPMYC 128
            :..|.:....|..||:..::.::..|::|.::.:.:.|....|| ||.|.|:..|...|.:||..
Yeast   134 IGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLI 198

  Fly   129 TEITATALRGTIGSFFQLLIVSGVLYGYLVGAFLPLLTINILCAI-LPVIFAIIHF------FMP 186
            :|::...:|||:.|.:||:|..|:..||.........|.::...: |.:.||...|      |:|
Yeast   199 SEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVPLGLGFAWALFMIGGMTFVP 263

  Fly   187 ESPVYLAMKGRNDDAAKALQWLRGKDADIDDELKEILEESQKQIDMPQV-------NILSSLRRP 244
            |||.||...|:.::|.:::.......|| |..:...:|..|..::..::       .|.|:..:
Yeast   264 ESPRYLVEVGKIEEAKRSIALSNKVSAD-DPAVMAEVEVVQATVEAEKLAGNASWGEIFSTKTK- 326

  Fly   245 IVLKGLGIAVLLQVFQQWTGINAVLFYSASIFEDTGSDISGSDATLIIGVTQVTSTLVAVAIIDK 309
             |.:.|.:..::|..||.||.|...:|..::|...|.:.| .:.::::|:....||.|.:.::::
Yeast   327 -VFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLEDS-FETSIVLGIVNFASTFVGIFLVER 389

  Fly   310 AGRRILLLISGVLMAVSTALMGVYFQL---------KENDPASMDNFGWLPISSICIFIIFFSIG 365
            .|||..||.....|   ||.|.|:..:         |:|  .|....|...|...|.::..|:..
Yeast   390 YGRRRCLLWGAASM---TACMVVFASVGVTRLWPNGKKN--GSSKGAGNCMIVFTCFYLFCFATT 449

  Fly   366 FGPVPWLVMAELFSEDVKSVAGSIAGTSNWLSAFVVTLLFPILKSSIGPGPTF---WIFTAIAVI 427
            :.|:|::|.:|.|...|||...:||...||:..|::....|.:..:|    .|   ::|....|.
Yeast   450 WAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPFISGAI----DFYYGYVFMGCLVF 510

  Fly   428 AFFYSLFFVPETKGKTIIEIQDLLSGG 454
            ::||..||||||||.|:.|:..|...|
Yeast   511 SYFYVFFFVPETKGLTLEEVNTLWEEG 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6484	NP_611234.1	Sugar_tr	14..451	CDD:278511	123/474 (26%)
CG6484	NP_611234.1	MFS	14..436	CDD:119392	114/459 (25%)
HXT4	NP_011960.2	Sugar_tr	74..534	CDD:395036	123/476 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342305
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.740