DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6484 and MPH3

DIOPT Version :9

Sequence 1:	NP_611234.1	Gene:	CG6484 / 36994	FlyBaseID:	FBgn0034247	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_012694.1	Gene:	MPH3 / 853625	SGDID:	S000003921	Length:	602	Species:	Saccharomyces cerevisiae

Alignment Length:	498	Identity:	116/498 - (23%)
Similarity:	197/498 - (39%)	Gaps:	124/498 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 YGFPISSSQFG--------W-VSSLLTLGATVICIPIGF---------AIDWIGRRPTM-LALIP 88
            |..||...:||        | :|:...:|.| :|...|.         ::|.:|.|.|: :||.
Yeast   122 YALPIFQRKFGSQNDKTGEWEISASWQIGLT-LCYMAGEIVGLQLTGPSVDLVGNRYTLIIALF- 184

  Fly    89 PYMVGWVLML-FAKNVTMLYFGRFILGMCGGAF-CVTAPMYCTEITATALRGTIGSFFQLLIVSG 151
             ::..:..:| |..::.|:..|:.:.||..|.| |:|. .|.:||...|||..:.::..|..:.|
Yeast   185 -FLAAFTFILYFCNSLGMIAVGQALCGMPWGCFQCLTV-SYASEICPLALRYYLTTYSNLCWLFG 247

  Fly   152 VLY--GYL-----------VGAFLPLLTINILCAILPVIFAIIHFFMPESPVYLAMKGRNDDAAK 203
            .|:  |.:           :|..||.    .|..||||..|:..||.||||.:|..|||.|:|.:
Yeast   248 QLFAAGIMKNSQKKYADSELGYKLPF----ALQWILPVPLALGIFFAPESPWWLVKKGRFDEARR 308

  Fly   204 AL-QWLRGKDADID-------DELKEILEESQKQIDMPQVNILSSLRRPIVLKGLGIAVLLQVFQ 260
            :| :.|.||..:.:       |::|..::: :|::...:.:........|..:...|..|....|
Yeast   309 SLRRTLSGKGPEKEILVTLEVDKIKVTIDK-EKRLTSKEGSYSDCFEDKINRRRTRITCLCWAGQ 372

  Fly   261 QWTGINAVLFYSASIFEDTGSDISGSDATLIIGVTQVTSTLVAVAI---------------IDKA 310
            ...| :.::.||...:|..|   ..::.:....:.|....:.|..:               ...|
Yeast   373 ATCG-SILIGYSTYFYEKAG---VSTEMSFTFSIIQYCLGICATFLSWWASKYFGRYDLYAFGLA 433

  Fly   311 GRRILLLISGVL---------MAVSTALMGVYFQLKENDPASMDNFGWLPISSICIFIIFFSIGF 366
            .:.|:..|.|.|         |...:.||.|.|                          |:::|.
Yeast   434 FQTIVFFIIGGLGCSSTHGSKMGSGSLLMAVAF--------------------------FYNLGI 472

  Fly   367 GPVPWLVMAELFSEDVKSVAGSIA-GTSNWLSAFVVTLLFPILKSSI----GPGPTFWIFTAIAV 426
            .||.:.:::|:.|..:::....:| .|.|.:|.....|:...|.|..    .....||     .|
Yeast   473 APVVFCLVSEMPSSRLRTKTIILARNTYNVVSIICSVLILYQLNSKKWNWGAKSGFFW-----GV 532

  Fly   427 IAF---FYSLFFVPETKGKTIIEIQDLLSGG------KGVKSD 460
            :.|   .:::..:|||.|||.:||.:|...|      |..|.|
Yeast   533 LCFCTLIWAVVDLPETAGKTFVEINELFKLGVSARKFKSTKVD 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6484	NP_611234.1	Sugar_tr	14..451	CDD:278511	111/481 (23%)
CG6484	NP_611234.1	MFS	14..436	CDD:119392	103/466 (22%)
MPH3	NP_012694.1	SP	72..556	CDD:273317	109/477 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342277
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740