DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6484 and HXT3

DIOPT Version :9

Sequence 1:	NP_611234.1	Gene:	CG6484 / 36994	FlyBaseID:	FBgn0034247	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_010632.1	Gene:	HXT3 / 851946	SGDID:	S000002753	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	484	Identity:	134/484 - (27%)
Similarity:	224/484 - (46%)	Gaps:	43/484 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KGSVLPQYIAGLSASFGALCMGASIGWSSPVENMITVNTEY-----------GFPISSSQFGWVS 56
            ||:.:...|..:..:||    |...||.:...:.....|::           .:.:|..:.|.:.
Yeast    56 KGAYVTVSICCVMVAFG----GFVFGWDTGTISGFVAQTDFLRRFGMKHKDGSYYLSKVRTGLIV 116

  Fly    57 SLLTLGATVICIPIGFAIDWIGRRPTMLALIPPYMVGWVLMLFAKNVTMLYF-GRFILGMCGGAF 120
            |:..:|..:..|.:....|..||:..::.::..|::|.::.:.:.|....|| ||.|.|:..|..
Yeast   117 SIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGI 181

  Fly   121 CVTAPMYCTEITATALRGTIGSFFQLLIVSGVLYGYLVGAFLPLLTINILCAI-LPVIFAIIHF- 183
            .|.:||..:|:....:|||:.|.:||:|..|:..||.........:.::...: |.:.||...|
Yeast   182 AVLSPMLISEVAPKEMRGTLVSCYQLMITLGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFM 246

  Fly   184 -----FMPESPVYLAMKGRNDDAAKALQWLRGKDAD---IDDELKEILEESQKQIDMPQVNILSS 240
                 |:||||.||...|:.|:|..:|..:.....|   |..|| |::|.|.::...........
Yeast   247 IGGMTFVPESPRYLVEAGQIDEARASLSKVNKVAPDHPFIQQEL-EVIEASVEEARAAGSASWGE 310

  Fly   241 L--RRPIVLKGLGIAVLLQVFQQWTGINAVLFYSASIFEDTGSDISGSDATLIIGVTQVTSTLVA 303
            |  .:|.:.|...:.:::|..||.||.|...:|..::|...|...| .:.:::.||....||..:
Yeast   311 LFTGKPAMFKRTMMGIMIQSLQQLTGDNYFFYYGTTVFNAVGMSDS-FETSIVFGVVNFFSTCCS 374

  Fly   304 VAIIDKAGRRILLLISGVLMA---VSTALMGVYFQLKENDP--ASMDNFGWLPISSICIFIIFFS 363
            :..:|:.|||..||...:.|.   |..|.:|| .:|..|..  .|....|...|...|.:|..|:
Yeast   375 LYTVDRFGRRNCLLYGAIGMVCCYVVYASVGV-TRLWPNGEGNGSSKGAGNCMIVFACFYIFCFA 438

  Fly   364 IGFGPVPWLVMAELFSEDVKSVAGSIAGTSNWLSAFVVTLLFPILKSSIGPGPTF---WIFTAIA 425
            ..:.|:.::|::|.|...|||.|.|||..:|||..|::....|.:..:|    .|   ::|....
Yeast   439 TTWAPIAYVVISETFPLRVKSKAMSIATAANWLWGFLIGFFTPFITGAI----NFYYGYVFMGCM 499

  Fly   426 VIAFFYSLFFVPETKGKTIIEIQDLLSGG 454
            |.|:||..||||||||.|:.|:.|:.:.|
Yeast   500 VFAYFYVFFFVPETKGLTLEEVNDMYAEG 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6484	NP_611234.1	Sugar_tr	14..451	CDD:278511	130/468 (28%)
CG6484	NP_611234.1	MFS	14..436	CDD:119392	120/453 (26%)
HXT3	NP_010632.1	Sugar_tr	65..525	CDD:395036	130/470 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342300
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.740