DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6484 and SLC2A4

DIOPT Version :9

Sequence 1:	NP_611234.1	Gene:	CG6484 / 36994	FlyBaseID:	FBgn0034247	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens

Alignment Length:	472	Identity:	156/472 - (33%)
Similarity:	238/472 - (50%)	Gaps:	53/472 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IAGLSASFGALCMGASIGWSSPVENMI--TVNTEY----------GFPISSSQFGWVSS--LLTL 61
            :|..||..|:|..|.:||..:..:.:|  :.|..:          ..|..:....|..|  :.::
Human    26 LAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSV 90

  Fly    62 GATVICIPIGFAIDWIGRRPTMLALIPPYMVGWVLMLFAK---NVTMLYFGRFILGMCGGAFCVT 123
            |..:....||....|:||:..||......::|..||..|.   :..||..|||::|...|.....
Human    91 GGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGL 155

  Fly   124 APMYCTEITATALRGTIGSFFQLLIVSGVLYGYLVG--------AFLPLLT-INILCAILPVIFA 179
            .|||..||..|.|||.:|:..||.||.|:|...::|        :..|||. :.:|.|:|.::..
Human   156 VPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLL 220

  Fly   180 IIHFFMPESPVYL-AMKGRNDDAAKALQWLRGKDADIDDELKEILEESQKQIDMPQVNILSSL-- 241
            .   |.||||.|| .::.....|.|:|:.|.|. ||:...|.|:.:|.:|......:::|..|
Human   221 P---FCPESPRYLYIIQNLEGPARKSLKRLTGW-ADVSGVLAELKDEKRKLERERPLSLLQLLGS 281

  Fly   242 ---RRPIVLKGLGIAVLLQVFQQWTGINAVLFYSASIFEDTGSDISGSDATLIIGVTQVTSTLVA 303
               |:|::     |||:||:.||.:|||||.:||.||||..|.. ..:.||:..||.....|||:
Human   282 RTHRQPLI-----IAVVLQLSQQLSGINAVFYYSTSIFETAGVG-QPAYATIGAGVVNTVFTLVS 340

  Fly   304 VAIIDKAGRRILLLISGVLMAVSTALMGVYFQLKENDPASMDNFGWLPISSICIFIIFFSIGFGP 368
            |.::::||||.|.|:....|.....||.|...|.|..||    ..::.|.:|..|:.||.||.||
Human   341 VLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPA----MSYVSIVAIFGFVAFFEIGPGP 401

  Fly   369 VPWLVMAELFSEDVKSVAGSIAGTSNWLSAFVVTLLFPILKSSIGPGPTFWIFTAIAVIA---FF 430
            :||.::|||||:..:..|.::||.|||.|.|::.:.|..:..::||    ::|...||:.   |.
Human   402 IPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGP----YVFLLFAVLLLGFFI 462

  Fly   431 YSLFFVPETKGKTIIEI 447
            ::...||||:|:|..:|
Human   463 FTFLRVPETRGRTFDQI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6484	NP_611234.1	Sugar_tr	14..451	CDD:278511	155/469 (33%)
CG6484	NP_611234.1	MFS	14..436	CDD:119392	148/456 (32%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269\|PubMed:16647043	7..13
		Sugar_tr	27..483	CDD:306568	156/471 (33%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		3/5 (60%)
		Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:8300557	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143920
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840