DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6484 and Slc2a6

DIOPT Version :9

Sequence 1:	NP_611234.1	Gene:	CG6484 / 36994	FlyBaseID:	FBgn0034247	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_766247.2	Gene:	Slc2a6 / 227659	MGIID:	2443286	Length:	497	Species:	Mus musculus

Alignment Length:	452	Identity:	129/452 - (28%)
Similarity:	237/452 - (52%)	Gaps:	17/452 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YIAGLSASFGALCMGASIGWSSPVENMITVNTEYGFPISSSQFGWVSSLLTLGATVICIPIGFAI 74
            ::|..:|..|....|.::.::|||...:.::::....:...|..|..|:.||||....:......
Mouse    38 FLATFAAVLGNFSFGYALVYTSPVIPELKLSSDPALHLDKIQASWFGSVFTLGAAAGGLSAMLLN 102

  Fly    75 DWIGRRPTMLALIPPYMVGWVLMLFAKNVTMLYFGRFILGMCGGAFCVTAPMYCTEITATALRGT 139
            |.:||:.:::....|..:|:.:|..|:.:.||..||.:.|..||......|:|.:||....:||.
Mouse   103 DLLGRKLSIMFSAVPSAIGYAIMAGARGLWMLLLGRMLTGFAGGLTAACIPVYVSEIAPPDVRGA 167

  Fly   140 IGSFFQLLIVSGVLYGYLVGAFLPLLTINILCAILPVIFAIIHFFMPESPVYLAMKGRNDDAAKA 204
            :|:..||:.|.|.|..|.:|..||...:.:......:|..::..|||.||.:|..|.|:::|.:|
Mouse   168 LGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEGPVLIMILLLSFMPNSPRFLLSKSRDEEALQA 232

  Fly   205 LQWLRGKDADIDDELKEILEESQKQIDMPQVNILSSLRRPIVLKGLGIAVLLQVFQQWTGINAVL 269
            |.|||. |:::..|.::|.:..::|.....   .:..|.|.|.:.:.||||::..||.|||..:|
Mouse   233 LTWLRA-DSEVHWEFEQIQDNVRRQSSRVS---WAEAREPRVYRPVLIAVLMRFLQQLTGITPIL 293

  Fly   270 FYSASIFEDTGSDISGSDATLIIGVTQVTSTLVAVAIIDKAGRRILLLISGVLMAVSTALMGVYF 334
            .|..:||::|...:.......|:|..::.|.|:|...:|.|||::||.:|..:|..:...:|:|.
Mouse   294 VYLQTIFDNTSVVLPSQQDAAIVGAVRLLSVLIAAVTMDLAGRKVLLYVSASVMFAANLTLGLYV 358

  Fly   335 Q-----LKENDPASMDNFG--------WLPISSICIFIIFFSIGFGPVPWLVMAELFSEDVKSVA 386
            |     |..|....:...|        .:|:.:..:||:.:::|:||:.||:|:|:.....:.||
Mouse   359 QFVPRPLTPNSTVEIVTLGDTAFNYLTLIPLLATMLFIMGYAMGWGPITWLLMSEVLPLRARGVA 423

  Fly   387 GSIAGTSNWLSAFVVTLLFPILKSSIGPGPTFWIFTAIAVIAFFYSLFFVPETKGKTIIEIQ 448
            ..:....:||:|||:|..|.:..::.|....|:.|:||.:::..::...||||:|:::.:|:
Mouse   424 SGLCVLVSWLTAFVLTNYFLLAVNAFGLQVPFFFFSAICLLSLLFTGCCVPETRGRSLEQIE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6484	NP_611234.1	Sugar_tr	14..451	CDD:278511	128/448 (29%)
CG6484	NP_611234.1	MFS	14..436	CDD:119392	122/434 (28%)
Slc2a6	NP_766247.2	Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS	38..483	CDD:391944	128/448 (29%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	284..290		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8886
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850