Protein Alignment Dcr-2 and RNT1

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_013966.1
• Gene: RNT1 / 855280
• SGDID: S000004852
• Length: 471
• Species: Saccharomyces cerevisiae
• Alignment Length: 497
• Identity: 105/497 - (21%)
• Similarity: 185/497 - (37%)
• Gaps: 144/497 - (28%)

  Fly   995 ILNRMYF----LLHA-EALRKRFNTYLNL--HLLPF----NGTDYMP---------RPLEIDYSL 1039
            |.|..|.    |.|| ..|.:.:|..:.|  :|:.:    |..|.:|         ..|::...|
Yeast    41 ISNYKYLEVIQLEHAVTKLVESYNKIIELSPNLVAYNEAVNNQDRVPVQILPSLSRYQLKLAAEL 105

  Fly  1040 KRNVDPLGNVIPTE--------DIEEPKSLLEPMPTKSIEASVANLE-ITEFENPWQKYMEPVDL 1095
            |...|...:.|.||        |.|:.:.:|:       |.|.|::| :.:.|...::..|.:|:
Yeast   106 KTLHDLKKDAILTEITDYENEFDTEQKQPILQ-------EISKADMEKLEKLEQVKREKREKIDV 163

  Fly  1096 SRNLLSTYPVELDYYYHFSVGNVCE-MNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPA 1159
                                 ||.| :||.:.|:::....:.            .|.|....|.|
Yeast   164 ---------------------NVYENLNEKEDEEEDEGEDSY------------DPTKAGDIVKA 195

  Fly  1160 LM--PSKPTVRG-KVKPLLILQKTVSKEHITPAEQGEFLAAITASSAADVFDMERLEILGDSFLK 1221
            ..  |..|.::. .::..:.:.|:..|:.:       :|:.....:|.:    ||||.||||.|.
Yeast   196 TKWPPKLPEIQDLAIRARVFIHKSTIKDKV-------YLSGSEMINAHN----ERLEFLGDSILN 249

  Fly  1222 LSATLYLASKYSDWNEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPPGISLPH 1286
            ...||.:.:|:.|::||.|:.::..||||..:....|..:..:.|.|     .:.......:..:
Yeast   250 SVMTLIIYNKFPDYSEGQLSTLRMNLVSNEQIKQWSIMYNFHEKLKT-----NFDLKDENSNFQN 309

  Fly  1287 NVLALWRENPEFAKIIG------PHN--------LRDL-------ALGDEESLVKGNCSDINYNR 1330
            ..|.|:.:  .|...||      |.|        ||.|       |..::.:|.|.:..|:|..|
Yeast   310 GKLKLYAD--VFEAYIGGLMEDDPRNNLPKIRKWLRKLAKPVIEEATRNQVALEKTDKLDMNAKR 372

  Fly  1331 FVEGCRANGQSFYAGADFSSEVNFCVGLVTI-------PNKVI------ADTLEALLGVIVKNYG 1382
                      ..|:...::|   ..:..||:       ||.::      ...|...:|..:|..|
Yeast   373 ----------QLYSLIGYAS---LRLHYVTVKKPTAVDPNSIVECRVGDGTVLGTGVGRNIKIAG 424

  Fly  1383 LQHA------FKMLEYFKICRADIDKPLTQLLNLELGGKKMR 1418
            ::.|      .|||:::...||.|.:..:.|.:.....||.:
Yeast   425 IRAAENALRDKKMLDFYAKQRAAIPRSESVLKDPSQKNKKRK 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792
		Dicer_PBD	241..343	CDD:277191
		SF2_C_dicer	360..506	CDD:350189
		Dicer_dimer	571..670	CDD:460900
		PAZ	843..1004	CDD:198017	4/12 (33%)
		RIBOc	1194..1391	CDD:238333	54/236 (23%)
		RIBOc	1448..1649	CDD:238333
		dsrm	1653..1717	CDD:425434
RNT1	NP_013966.1	RNase_3_N	44..147	CDD:436545	25/109 (23%)
		RIBOc	207..354	CDD:238333	37/164 (23%)
		DSRM_RNT1p-like	367..436	CDD:380705	14/81 (17%)