DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcr-2 and MRPL3

DIOPT Version :9

Sequence 1:	NP_523778.2	Gene:	Dcr-2 / 36993	FlyBaseID:	FBgn0034246	Length:	1722	Species:	Drosophila melanogaster
Sequence 2:	NP_013737.1	Gene:	MRPL3 / 855039	SGDID:	S000004626	Length:	390	Species:	Saccharomyces cerevisiae

Alignment Length:	427	Identity:	89/427 - (20%)
Similarity:	141/427 - (33%)	Gaps:	160/427 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1330 RFV-EGCRANGQSFYAGADFSSEVNFCVGLVTIPNKVIADTLEALLGVIVKNYGLQHAFKMLE-- 1391
            ||: |...|..:.:|.|  ..|.||      .||..|.:           |:..|:...|.|:
Yeast    63 RFLPESELAKYKEYYQG--LKSTVN------EIPESVAS-----------KSPSLRTLHKRLQLP 108

  Fly  1392 ----YFKICRADIDKPLTQLLNLELGGKKMRANVNTTEIDGFLINH--YYLEKNLGYTFKDRRYL 1450
                |..:.|. :..|..:|.:......|..|.|||...:.:|.||  ..:.||| .::...:.:
Yeast   109 NELTYSTLSRC-LTCPSAKLPDKINNPTKGAAFVNTVPTNKYLDNHGLNIMGKNL-LSYHVTKSI 171

  Fly  1451 LQALTHPSYPT---NRITGSYQELEFIGDAILDFLISAYIFENNT--------KMNPGALTDLRS 1504
            :|  .:|..||   |....:|     |.:|:|..:...:..|..|        ||.|...|
Yeast   172 IQ--KYPRLPTVVLNAAVNAY-----ISEAVLAHIAKYWGIEVETTSVLSRYLKMEPFEFT---- 225

  Fly  1505 ALVNNTTLACICVRHRLHFFILAENAK--LSEIISKFVNFQESQGHRVTNYVRILL-------EE 1560
                         ..||.||..:.|:|  :..|..|  ||.|:....::  ||.::       |:
Yeast   226 -------------LGRLKFFNNSLNSKDGIELITGK--NFSETSALAMS--VRSIIAAIWAVTEQ 273

  Fly  1561 ADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNVDVPKALGDVLEALIAAVYL 1625
            .|.|.....:||.:                           ||..:|:.|
Yeast   274 KDSQAVYRFIDDHI---------------------------MSRKLDITK--------------- 296

  Fly  1626 DCRDLQRTWEVIFNLFEPELQEFTRKVPINHIRQLVEHKHAK-----------PVFSSPIVEGET 1679
                       :|...:|     ||::.:...|:.:|...:|           |||...:..||.
Yeast   297 -----------MFQFEQP-----TRELAMLCRREGLEKPVSKLVAESGRLSKSPVFIVHVFSGEE 345

  Fly  1680 VMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQQ 1716
            .:..             |:||:..:||..||..||.:
Yeast   346 TLGE-------------GYGSSLKEAKARAATDALMK 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	MPH1	6..542	CDD:224036
		DEXDc	22..173	CDD:238005
		Dicer_PBD	241..343	CDD:277191
		HELICc	<438..495	CDD:197757
		Dicer_dimer	572..665	CDD:281376
		PAZ	843..1004	CDD:198017
		RIBOc	1194..1391	CDD:238333	15/61 (25%)
		Rnc	1433..1719	CDD:223644	62/317 (20%)
		RIBOc	1448..1649	CDD:238333	39/220 (18%)
		dsrm	1653..1717	CDD:278464	17/75 (23%)
MRPL3	NP_013737.1	Rnc	114..376	CDD:223644	72/357 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900