DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-2 and DCL1

DIOPT Version :9

Sequence 1:NP_523778.2 Gene:Dcr-2 / 36993 FlyBaseID:FBgn0034246 Length:1722 Species:Drosophila melanogaster
Sequence 2:NP_001184881.1 Gene:DCL1 / 839574 AraportID:AT1G01040 Length:1910 Species:Arabidopsis thaliana


Alignment Length:1900 Identity:445/1900 - (23%)
Similarity:741/1900 - (39%) Gaps:531/1900 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 VEIKPRGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRAL--FMCNT 66
            ||.:.|.|||.:::.....|.|.:|.||:|||.:|||::|...:|    :.|..::.|  |:...
plant   245 VEEQARRYQLDVLEQAKAKNTIAFLETGAGKTLIAILLIKSVHKD----LMSQNRKMLSVFLVPK 305

  Fly    67 VELARQQAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVTQTYVALS 131
            |.|..|||..:|..|.|:||.|.||.|.|.|....|..|.:..||||.|||:.|:::..:.:.:.
plant   306 VPLVYQQAEVIRNQTCFQVGHYCGEMGQDFWDSRRWQREFESKQVLVMTAQILLNILRHSIIRME 370

  Fly   132 SLSVVIIDECHHGTGHHPFREFM-RLFTIANQTKLPRVVGLTG--VLIKG-NEITNVATKLKELE 192
            ::.::|:|||||....||:...| ..:....:.|.|.:.|:|.  |.:|| :...:.|.|::.||
plant   371 TIDLLILDECHHAVKKHPYSLVMSEFYHTTPKDKRPAIFGMTASPVNLKGVSSQVDCAIKIRNLE 435

  Fly   193 ITYRGNIITVSDTKEMENVMLYATKPTEVMVSFP--------HQEQVLTVTRLISAEIEKFYVSL 249
            ......:.|:.|.||:|.   :...|:|::|.:.        |:    |:.::|:|..|....| 
plant   436 TKLDSTVCTIKDRKELEK---HVPMPSEIVVEYDKAATMWSLHE----TIKQMIAAVEEAAQAS- 492

  Fly   250 DLMNIGVQPIRRSK-SLQCLRDPSKKSFVKQLF---------------------NDFLYQMKEYG 292
                     .|:|| .....||...|..::|::                     |..|.::.::.
plant   493 ---------SRKSKWQFMGARDAGAKDELRQVYGVSERTESDGAANLIHKLRAINYTLAELGQWC 548

  Fly   293 IYAASIAIISLI-----VEF--DIKRRQAETLSVKLMHRTALTLCEKIRHLLVQKL--------Q 342
            .|....:.:|.:     |.|  |:|.:::....|     .:|..||.:.....:|:        .
plant   549 AYKVGQSFLSALQSDERVNFQVDVKFQESYLSEV-----VSLLQCELLEGAAAEKVAAEVGKPEN 608

  Fly   343 DMTYDD------DDDNV-----NTEEVI-----MNFSTPKVQRFLMSLKVSFADKDPKDICCLVF 391
            ...:|:      .||.|     :.:|||     ....|||||..   :|:....:...|...:||
plant   609 GNAHDEMEEGELPDDPVVSGGEHVDEVIGAAVADGKVTPKVQSL---IKLLLKYQHTADFRAIVF 670

  Fly   392 VERRYTCKCIYGLLLNYIQSTPELRNVLTPQFMVGRNNISPDFESVLERKWQKSAIQQFRDGNAN 456
            |||     .:..|:|..:.:.....:.:....|:|.|| |.:.:|    ...:..|.:||||:..
plant   671 VER-----VVAALVLPKVFAELPSLSFIRCASMIGHNN-SQEMKS----SQMQDTISKFRDGHVT 725

  Fly   457 LMICSSVLEEGIDVQACNHVFILDPVKTFNMYVQSKGRARTTEAKFVLFTADKEREKTIQQIYQY 521
            |::.:||.|||:|::.||.|...|..||...|:||:||||...:.::|..   ||.......: .
plant   726 LLVATSVAEEGLDIRQCNVVMRFDLAKTVLAYIQSRGRARKPGSDYILMV---ERGNVSHAAF-L 786

  Fly   522 RKAHNDIAEYLKDRVLEKTEPELYEIKGHFQD-------DIDPFT----NENGAVLLPNNALAIL 575
            |.|.|. .|.|:...:|:|:      ..|.:|       |..|.|    ...||::..|:|:.::
plant   787 RNARNS-EETLRKEAIERTD------LSHLKDTSRLISIDAVPGTVYKVEATGAMVSLNSAVGLV 844

  Fly   576 HRYCQTIPTDAFGFVIPWFHVLQEDERDRIFGVSAKGKHV-ISINMPVNCMLRDTIYSDPM-DNV 638
            |.||..:|.|.:..:.|.|.:.:.::         .|.|. .|..:.:.|.....|...|: .::
plant   845 HFYCSQLPGDRYAILRPEFSMEKHEK---------PGGHTEYSCRLQLPCNAPFEILEGPVCSSM 900

  Fly   639 KTAKISAAFKACKVLYSLGELNERFVPKTLKERVASIADVHFEHWNKYGDSVTATVNKADKSKDR 703
            :.|:.:....|||.|:.:|...:..:|.....:.|..||...|     |:.|..|....      
plant   901 RLAQQAVCLAACKKLHEMGAFTDMLLPDKGSGQDAEKADQDDE-----GEPVPGTARHR------ 954

  Fly   704 TYKTECPLEFY-----DALPRVG-------EICYAYEIFLEPQFESCEYTEHMYLN--------- 747
                    |||     |.|.  |       |:|.:.::|            |:|:.         
plant   955 --------EFYPEGVADVLK--GEWVSSGKEVCESSKLF------------HLYMYNVRCVDFGS 997

  Fly   748 -----LQTPRNYAILLRNKLPRLAEMPLFSNQGKLHVRVANAPLEVIIQNS-----EQLELLHQF 802
                 |.....:|||..|:|.  ||:.|..:......|.......:..:.|     .||..|.:|
plant   998 SKDPFLSEVSEFAILFGNELD--AEVVLSMSMDLYVARAMITKASLAFKGSLDITENQLSSLKKF 1060

  Fly   803 HGMVFRDILKI--------WHPFFVLDRRSKENSYLVVPLILGAGEQ--KCFDWELMTNFRRLPQ 857
            |..:...:|.:        |.|         ..:||.||:......:  |..:|||:....:   
plant  1061 HVRLMSIVLDVDVEPSTTPWDP---------AKAYLFVPVTDNTSMEPIKGINWELVEKITK--- 1113

  Fly   858 SHGSNVQQREQQPAPRPEDFEGKIVTQWYANYDKPMLVTKVHRELTPLSYMEKNQQ----DKTYY 918
                                    .|.|    |.|:      :...|..|:..|::    |:..|
plant  1114 ------------------------TTAW----DNPL------QRARPDVYLGTNERTLGGDRREY 1144

  Fly   919 EFTMSKYGNRIGDVVH---------------KDKFMIEVRDLTEQLTFYVHNRGKFNAKSKAKMK 968
            .|...::....|...|               :...::.|||..|:......::||          
plant  1145 GFGKLRHNIVFGQKSHPTYGIRGAVASFDVVRASGLLPVRDAFEKEVEEDLSKGK---------- 1199

  Fly   969 VILIPELCFNFNFPGDLWLKLIFLPSILNRMY-----FLLHAEALRKR---------FNTYLNLH 1019
             :::.:.|.   ...||..|::.......|.|     :.:.||....|         :|||    
plant  1200 -LMMADGCM---VAEDLIGKIVTAAHSGKRFYVDSICYDMSAETSFPRKEGYLGPLEYNTY---- 1256

  Fly  1020 LLPFNGTDYMPRPLEIDYSLKRNVDPLGNVIPTEDIEEPKSLLEPMPTKSIEASVANLEITEFEN 1084
                  .||..:...:|.:.|:  .||   |....:...|:||.|...:|.|:... |:.|    
plant  1257 ------ADYYKQKYGVDLNCKQ--QPL---IKGRGVSYCKNLLSPRFEQSGESETV-LDKT---- 1305

  Fly  1085 PWQKYMEPVDLSRNLLSTYPVELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRT 1149
                                     ||.|....:|.:                |..:|::     
plant  1306 -------------------------YYVFLPPELCVV----------------HPLSGSL----- 1324

  Fly  1150 PAKTNANVPALMPSKPTVRGKVKPLLI---LQKTVSKEHITPAEQGEFLAAITASSAADVFDMER 1211
             .:....:|::|       .:|:.:|:   |:..:|    .|....:.|.|:||:|..:.|..||
plant  1325 -IRGAQRLPSIM-------RRVESMLLAVQLKNLIS----YPIPTSKILEALTAASCQETFCYER 1377

  Fly  1212 LEILGDSFLKLSATLYLASKYSDWNEGTLTEVKSKLVSNRNLL-FCLIDADIPKTLNTIQFTPRY 1275
            .|:|||::||...:.:|..||...:||.||.::.::|||..|. |.|:.. :...:...:|.|. 
plant  1378 AELLGDAYLKWVVSRFLFLKYPQKHEGQLTRMRQQMVSNMVLYQFALVKG-LQSYIQADRFAPS- 1440

  Fly  1276 TWLPPGISLPHNVLALWRENPEFAKIIGPHNLRDLALGDEESLVKGN---------CSDINYNRF 1331
            .|..||:.            |.|               ||::...|:         .|:.|.:.|
plant  1441 RWSAPGVP------------PVF---------------DEDTKDGGSSFFDEEQKPVSEENSDVF 1478

  Fly  1332 VEGCRANGQSFYAGADFSSEVNFCVGLVTIPNKVIADTLEALLGVIVKNYGLQHAFKMLEYFKIC 1396
            .:|...:|:   ...|.||       ...:.:|.:||.:|||:||.....|...|..::::..|.
plant  1479 EDGEMEDGE---LEGDLSS-------YRVLSSKTLADVVEALIGVYYVEGGKIAANHLMKWIGIH 1533

  Fly  1397 RAD----IDKPLTQLLNLELGGKKMRANVNTTEIDGFLINHYYLEKNLGYTFKDRRYLLQALTHP 1457
            ..|    :|..|              .|||..|.....|:...||:.|.|.||::..|::|:||.
plant  1534 VEDDPDEVDGTL--------------KNVNVPESVLKSIDFVGLERALKYEFKEKGLLVEAITHA 1584

  Fly  1458 SYPTNRITGSYQELEFIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLH 1522
            |.|::.:: .||.|||:|||:||.||:.::|...|.:.||.|||||:|.|||...|.:.|:|:||
plant  1585 SRPSSGVS-CYQRLEFVGDAVLDHLITRHLFFTYTSLPPGRLTDLRAAAVNNENFARVAVKHKLH 1648

  Fly  1523 FFILAENAKLSEIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCIS 1587
            .::...::.|.:.|.:||.                    :||                       
plant  1649 LYLRHGSSALEKQIREFVK--------------------EVQ----------------------- 1670

  Fly  1588 QEAEKGVPPKGEFNMSTNVDVPKALGDVLEALIAAVYLDC-RDLQRTWEVIFNLFEPELQEFT-- 1649
              .|...|....|.:. :...||.|||::|::..|::||. :|....|:|    |:|.||...  
plant  1671 --TESSKPGFNSFGLG-DCKAPKVLGDIVESIAGAIFLDSGKDTTAAWKV----FQPLLQPMVTP 1728

  Fly  1650 RKVPINHIRQLVE--HKHAKPVFSSPIVEGETVMVSCQFTCMEKTIKVY------GFGSN--KDQ 1704
            ..:|::.:|:|.|  .:.|:.:.......|.|.           |::|:      |...|  |..
plant  1729 ETLPMHPVRELQERCQQQAEGLEYKASRSGNTA-----------TVEVFIDGVQVGVAQNPQKKM 1782

  Fly  1705 AKLSAAKHALQQLSK 1719
            |:..||::||..|.:
plant  1783 AQKLAARNALAALKE 1797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-2NP_523778.2 MPH1 6..542 CDD:224036 162/602 (27%)
DEXDc 22..173 CDD:238005 54/153 (35%)
Dicer_PBD 241..343 CDD:277191 22/138 (16%)
HELICc <438..495 CDD:197757 22/56 (39%)
Dicer_dimer 572..665 CDD:281376 19/94 (20%)
PAZ 843..1004 CDD:198017 27/184 (15%)
RIBOc 1194..1391 CDD:238333 55/206 (27%)
Rnc 1433..1719 CDD:223644 85/298 (29%)
RIBOc 1448..1649 CDD:238333 61/201 (30%)
dsrm 1653..1717 CDD:278464 17/73 (23%)
DCL1NP_001184881.1 DEXDc 250..456 CDD:214692 71/212 (33%)
DEXDc 263..415 CDD:238005 55/155 (35%)
Helicase_C 648..764 CDD:278689 40/128 (31%)
Dicer_dimer 841..927 CDD:281376 19/94 (20%)
PAZ_CAF_like 1177..1321 CDD:239210 38/218 (17%)
RIBOc 1358..1537 CDD:238333 56/217 (26%)
Rnc 1558..1785 CDD:223644 81/288 (28%)
RIBOc 1576..1731 CDD:238333 61/205 (30%)
DSRM 1735..1785 CDD:214634 12/60 (20%)
DSRM 1832..1905 CDD:294045
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 113 1.000 Domainoid score I2031
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57860
OrthoDB 1 1.010 - - D1337630at2759
OrthoFinder 1 1.000 - - FOG0002051
OrthoInspector 1 1.000 - - mtm1149
orthoMCL 1 0.900 - - OOG6_101152
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1728
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.690

Return to query results.
Submit another query.