DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dcr-2 and DCL4

DIOPT Version :9

Sequence 1:NP_523778.2 Gene:Dcr-2 / 36993 FlyBaseID:FBgn0034246 Length:1722 Species:Drosophila melanogaster
Sequence 2:NP_197532.3 Gene:DCL4 / 832154 AraportID:AT5G20320 Length:1702 Species:Arabidopsis thaliana


Alignment Length:1796 Identity:402/1796 - (22%)
Similarity:687/1796 - (38%) Gaps:481/1796 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVELARQQ 73
            |.||:.|....|:.|.||||.||.|||.:|::::.........|.:|   ..:|:..||.|..||
plant   125 RRYQVELCKKATEENVIVYLGTGCGKTHIAVMLIYELGHLVLSPKKS---VCIFLAPTVALVEQQ 186

  Fly    74 AMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVTQTYVALSSLSVVII 138
            |..:....||||..:.|.:.:.. :...|..||..|:|||.|.|:.|..:...::.:..:|::|.
plant   187 AKVIADSVNFKVAIHCGGKRIVK-SHSEWEREIAANEVLVMTPQILLHNLQHCFIKMECISLLIF 250

  Fly   139 DECHHG--TGHHPFREFMRLFTIANQTKLPRVVGLTG--VLIKGN-EITNVATKLKELEITYRGN 198
            |||||.  ..:||:.|.|::|..:...:.||:.|:|.  |:.||: :..|::..:..||......
plant   251 DECHHAQQQSNHPYAEIMKVFYKSESLQRPRIFGMTASPVVGKGSFQSENLSKSINSLENLLNAK 315

  Fly   199 IITVSDTKEMENVMLYATKPTEVMVSFPHQEQVLTVTRLISAEIEKFYVSLDLMNIGVQPIRRSK 263
            :.:|....:::.           .||.|              .::.:|....|.:.....||...
plant   316 VYSVESNVQLDG-----------FVSSP--------------LVKVYYYRSALSDASQSTIRYEN 355

  Fly   264 SLQ-----CLRD-------------PSKKSFVKQLFNDFLYQMKEYGIYAA-SIAIISLIVEFDI 309
            .|:     ||..             .|.|..:|:..::.:|.:...|::.| ..|.|.|..:.::
plant   356 MLEDIKQRCLASLKLLIDTHQTQTLLSMKRLLKRSHDNLIYTLLNLGLWGAIQAAKIQLNSDHNV 420

  Fly   310 KRRQAETLSVKLMHRTALTLCEKIRHLLVQKLQDMTYDDDDDNVNTEEVIMNFSTPKVQRFLMSL 374
               |.|.:......:    :|:....:..:.|....  ..|:|.:....:.....|...|.|:.|
plant   421 ---QDEPVGKNPKSK----ICDTYLSMAAEALSSGV--AKDENASDLLSLAALKEPLFSRKLVQL 476

  Fly   375 -KVSFADKDPKDICCLVFVERRYTCKCIYGLLLNYIQSTPELRNVLTPQFMVGRNNISPDFESVL 438
             |:....:....:.|::||.|..|.:.:..:|.|.     ||.......|:||   :|...:| :
plant   477 IKILSVFRLEPHMKCIIFVNRIVTARTLSCILNNL-----ELLRSWKSDFLVG---LSSGLKS-M 532

  Fly   439 ERKWQKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFILDPVKTFNMYVQSKGRARTTEAKFV 503
            .|:..::.:::|:....||::.:.|.|||:|:|.|..|...|..:|...::||:||||..::::.
plant   533 SRRSMETILKRFQSKELNLLVATKVGEEGLDIQTCCLVIRYDLPETVTSFIQSRGRARMPQSEYA 597

  Fly   504 LFTADKEREKTIQQIYQYRKAHNDIAEYLKDRVLEKTEP----ELYEIKGHFQDDIDPFTNENGA 564
             |..|...||.:..|..::...:.:...:..|..|:|.|    |||::            :|.||
plant   598 -FLVDSGNEKEMDLIENFKVNEDRMNLEITYRSSEETCPRLDEELYKV------------HETGA 649

  Fly   565 VLLPNNALAILHRYCQTIPTDAFGFVIPWFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRDT 629
            .:...:::::|::||..:|.|.|....|.|.....||    ||.:     :..|.:|.|..:.: 
plant   650 CISGGSSISLLYKYCSRLPHDEFFQPKPEFQFKPVDE----FGGT-----ICRITLPANAPISE- 704

  Fly   630 IYSDPMDNVKTAKISAAFKACKVLYSLGELNERFVPKTLKERVASIADVHFEHWNKYGDSVTATV 694
            |.|..:.:.:.||..|..||...|::||.||:..:|.:..|....::|..|:..|..|:..    
plant   705 IESSLLPSTEAAKKDACLKAVHELHNLGVLNDFLLPDSKDEIEDELSDDEFDFDNIKGEGC---- 765

  Fly   695 NKADKSKDRTYKTECPLEF---YDALPRVGEI-CYAYEIFLEPQFESCEYTEHMYLNLQTPRNYA 755
                 |:...|:...|:.|   :|  |....: .::|.|...|     ...:.:|      :.:.
plant   766 -----SRGDLYEMRVPVLFKQKWD--PSTSCVNLHSYYIMFVP-----HPADRIY------KKFG 812

  Fly   756 ILLRNKLPRLAE-MPL---FSNQGKLHVRVANAPLEVIIQNSEQLELLHQFHGMVFR------DI 810
            ..:::.||..|| |.:   .::|..:.|::  .|..|...:::::.|...|..:..:      ::
plant   813 FFMKSPLPVEAETMDIDLHLAHQRSVSVKI--FPSGVTEFDNDEIRLAELFQEIALKVLFERGEL 875

  Fly   811 LKIWHPFFVLD--RRSKENSYLVVPLILGAGEQK-CFDWELMTNFRRLPQSHGSNVQQREQQPAP 872
            :..:.|..:.|  |.||...||::||.|..||.. ..||..:.|....|.....:|...:..|  
plant   876 IPDFVPLELQDSSRTSKSTFYLLLPLCLHDGESVISVDWVTIRNCLSSPIFKTPSVLVEDIFP-- 938

  Fly   873 RPEDFEGKIVTQ-WYANYDKPMLVTKVHRELTPLSYMEKNQQDKTYYEFTMSKYGNRIGDVVHKD 936
             |.....|:... |  |.|      .|...|...:|      .|.:|                  
plant   939 -PSGSHLKLANGCW--NID------DVKNSLVFTTY------SKQFY------------------ 970

  Fly   937 KFMIEVRDLTEQLTFYVHNRGKFNAKSKAKMKVILIPELCFNFNFPGDLWLKLIFLPSILNRMYF 1001
             |:.::          .|.|..|:...::..|                                 
plant   971 -FVADI----------CHGRNGFSPVKESSTK--------------------------------- 991

  Fly  1002 LLHAEALRKRFNTYLNLHLLPFNGTDYMPRPLEIDYSLKRNVDPLGNVIPTEDIEEPKSLLEPMP 1066
             .|.|::.|.:..                       .||....||..|.|.              
plant   992 -SHVESIYKLYGV-----------------------ELKHPAQPLLRVKPL-------------- 1018

  Fly  1067 TKSIEASVANLEITEFENPWQKYMEPVDLSRNLLSTYPVELDYYYHFSVGNVCEMNEMDFEDKEY 1131
                 ..|.||    ..|..|..:||.:|....:. .|.||.   |..:..:             
plant  1019 -----CHVRNL----LHNRMQTNLEPQELDEYFIE-IPPELS---HLKIKGL------------- 1057

  Fly  1132 WAKNQFHMPTGNIYGNRTPAKTNANVPALMPSKPTVRGKVKPLLILQKTVSKEHITPAEQGEF-- 1194
                               :|...:..:|:||   :..:::.||:   .:..:|:..|...|.  
plant  1058 -------------------SKDIGSSLSLLPS---IMHRMENLLV---AIELKHVLSASIPEIAE 1097

  Fly  1195 ------LAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEGTLTEVKSKLVSNRNL 1253
                  |.|:|.....:...:||||:|||:|||.:.:.:|...:...:||.||..:|.:|:|.||
plant  1098 VSGHRVLEALTTEKCHERLSLERLEVLGDAFLKFAVSRHLFLHHDSLDEGELTRRRSNVVNNSNL 1162

  Fly  1254 LFCLIDADIPKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAKIIGPHNLRDLALGDEESL 1318
              |.:  .|.|.|...                                     :||.||...:..
plant  1163 --CRL--AIKKNLQVY-------------------------------------IRDQALDPTQFF 1186

  Fly  1319 VKGN-----CSDI------NYNRFVEGCRANGQSFYAGADFSSEVNFCVGLVTIPNKVIADTLEA 1372
            ..|:     |.::      :.||.:....:|          :.|:....|...:..|.|||.:||
plant  1187 AFGHPCRVTCDEVASKEVHSLNRDLGILESN----------TGEIRCSKGHHWLYKKTIADVVEA 1241

  Fly  1373 LLGVIVKNYGLQHAFKMLEYFKICRADIDKPLTQLLNLELGGKK-----MRANVNTTEIDGFLIN 1432
            |:|..:.:.|.:.|.|.|::..:   ::|....|:.:..:..::     .|.|:.|         
plant  1242 LVGAFLVDSGFKGAVKFLKWIGV---NVDFESLQVQDACIASRRYLPLTTRNNLET--------- 1294

  Fly  1433 HYYLEKNLGYTFKDRRYLLQALTHPSYPTNRITGS-YQELEFIGDAILDFLISAYIFENNTKMNP 1496
               ||..|.|.|..:..|:||..||||  ||..|. ||.|||:|||:||:|:::|.|....|:.|
plant  1295 ---LENQLDYKFLHKGLLVQAFIHPSY--NRHGGGCYQRLEFLGDAVLDYLMTSYFFTVFPKLKP 1354

  Fly  1497 GALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVNFQESQGHRVTNYVRILLEEA 1561
            |.||||||..|||..||.:.|...|..|:..|:..|.|:|..:.||..|                
plant  1355 GQLTDLRSLSVNNEALANVAVSFSLKRFLFCESIYLHEVIEDYTNFLAS---------------- 1403

  Fly  1562 DVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNVDVPKALGDVLEALIAAVYLD 1626
                :||    ....:|.|   :|                       ||.|||::|:.:.|::||
plant  1404 ----SPL----ASGQSEGP---RC-----------------------PKVLGDLVESCLGALFLD 1434

  Fly  1627 CR-DLQRTWEVIFNLFEP-----ELQEFTRKVPINHIRQLVE----HKHAKPVFSSP-----IVE 1676
            |. :|...|.::.:..:|     .||       |:.|::|:|    :|..:.:.::.     .||
plant  1435 CGFNLNHVWTMMLSFLDPVKNLSNLQ-------ISPIKELIELCQSYKWDREISATKKDGAFTVE 1492

  Fly  1677 GETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQQL 1717
            .:.....|..|       |...|.||.:....||:..:..|
plant  1493 LKVTKNGCCLT-------VSATGRNKREGTKKAAQLMITNL 1526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-2NP_523778.2 MPH1 6..542 CDD:224036 135/557 (24%)
DEXDc 22..173 CDD:238005 50/152 (33%)
Dicer_PBD 241..343 CDD:277191 20/120 (17%)
HELICc <438..495 CDD:197757 17/56 (30%)
Dicer_dimer 572..665 CDD:281376 27/92 (29%)
PAZ 843..1004 CDD:198017 21/161 (13%)
RIBOc 1194..1391 CDD:238333 49/215 (23%)
Rnc 1433..1719 CDD:223644 88/301 (29%)
RIBOc 1448..1649 CDD:238333 67/207 (32%)
dsrm 1653..1717 CDD:278464 15/72 (21%)
DCL4NP_197532.3 MPH1 124..640 CDD:224036 136/562 (24%)
DEXDc 138..289 CDD:238005 51/154 (33%)
Helicase_C 470..589 CDD:278689 35/127 (28%)
Dicer_dimer 657..740 CDD:281376 27/92 (29%)
PAZ 937..1080 CDD:198017 42/307 (14%)
RIBOc 1104..1261 CDD:238333 50/207 (24%)
Rnc 1285..1531 CDD:223644 91/320 (28%)
RIBOc 1308..1452 CDD:238333 64/195 (33%)
DSRM 1463..1527 CDD:214634 15/71 (21%)
DSRM 1621..>1681 CDD:238007
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 113 1.000 Domainoid score I2031
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57860
OrthoDB 1 1.010 - - D1337630at2759
OrthoFinder 1 1.000 - - FOG0002051
OrthoInspector 1 1.000 - - mtm1149
orthoMCL 1 0.900 - - OOG6_101152
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1728
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.690

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