DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcr-2 and RTL2

DIOPT Version :9

Sequence 1:	NP_523778.2	Gene:	Dcr-2 / 36993	FlyBaseID:	FBgn0034246	Length:	1722	Species:	Drosophila melanogaster
Sequence 2:	NP_566661.1	Gene:	RTL2 / 821587	AraportID:	AT3G20420	Length:	391	Species:	Arabidopsis thaliana

Alignment Length:	293	Identity:	84/293 - (28%)
Similarity:	128/293 - (43%)	Gaps:	70/293 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1436 LEKNLGYTFKDRRYLLQALTHPS---YPTNRITGSYQELEFIGDAILDFLISAYIFENNTKMNPG 1497
            :||.|.|.|.::..|.:|:||.|   :|      ||:.||||||:.:...||.|::.....:.|.
plant    63 VEKILNYKFSNKSLLKEAITHTSCTDFP------SYERLEFIGDSAIGLAISNYLYLTYPSLEPH 121

  Fly  1498 ALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVNFQESQGHRVTNYVRILLEEAD 1562
            .|:.||:|.|:...||.:.:.|.|:.|:......|.|   |...|.|:.|.
plant   122 DLSLLRAANVSTEKLARVSLNHGLYSFLRRNAPSLDE---KVKEFSEAVGK-------------- 169

  Fly  1563 VQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNVDVPKALGDVLEALIAAVYLDC 1627
                    :|:|.:                        :....|..||.|.|:.|:|..|||:|.
plant   170 --------EDDLSV------------------------SYGGLVKAPKVLADLFESLAGAVYVDV 202

  Fly  1628 R-DLQRTWEVIFNLFEP-----ELQEFTRKVPINHIRQLVEHKHAKPVFSSPIVEGETVMVSCQF 1686
            . ||||.|.:...|.||     :||:  :..|::.:.:|. |||.|.:......:|.   ||...
plant   203 NFDLQRLWVIFRGLLEPIVTLDDLQK--QPQPVSMLFKLC-HKHKKRIDIKNWKDGN---VSIAV 261

  Fly  1687 TCMEKTIKVYGFGSNKDQAKLSAAKHALQQLSK 1719
            ..::..:...|...|||.|:|.|||.||::||:
plant   262 IYLDDELLASGRAENKDIARLIAAKEALRKLSE 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	MPH1	6..542	CDD:224036
		DEXDc	22..173	CDD:238005
		Dicer_PBD	241..343	CDD:277191
		HELICc	<438..495	CDD:197757
		Dicer_dimer	572..665	CDD:281376
		PAZ	843..1004	CDD:198017
		RIBOc	1194..1391	CDD:238333
		Rnc	1433..1719	CDD:223644	83/291 (29%)
		RIBOc	1448..1649	CDD:238333	57/209 (27%)
		dsrm	1653..1717	CDD:278464	20/63 (32%)
RTL2	NP_566661.1	Rnc	54..294	CDD:223644	83/291 (29%)
		RIBOc	75..226	CDD:238333	55/205 (27%)
		dsrm	232..292	CDD:278464	20/63 (32%)
		DSRM	313..385	CDD:238007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810