DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dcr-2 and DCL2

DIOPT Version :9

Sequence 1:NP_523778.2 Gene:Dcr-2 / 36993 FlyBaseID:FBgn0034246 Length:1722 Species:Drosophila melanogaster
Sequence 2:NP_001189798.1 Gene:DCL2 / 821300 AraportID:AT3G03300 Length:1388 Species:Arabidopsis thaliana


Alignment Length:1805 Identity:403/1805 - (22%)
Similarity:670/1805 - (37%) Gaps:525/1805 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EDVEIKP----RGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALF 62
            :.|...|    |.||:..::...|.|.||:|.||||||.:||::|:.::..|.||...   ..:|
plant    14 DQVSASPLHFARSYQVEALEKAIKQNTIVFLETGSGKTLIAIMLLRSYAYLFRKPSPC---FCVF 75

  Fly    63 MCNTVELARQQAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVTQTY 127
            :...|.|..|||.|::..|:.|||.|.|:.|||.|....|..|:.|.:|||.|..:.||.:..::
plant    76 LVPQVVLVTQQAEALKMHTDLKVGMYWGDMGVDFWDSSTWKQEVDKYEVLVMTPAILLDALRHSF 140

  Fly   128 VALSSLSVVIIDECHHGTGHHPF----REFMRLFTIANQTKLPRVVGLTGVLI--KGNEITNVAT 186
            ::||.:.|:|:|||||..|.||:    |||......:..:.:||:.|:|..|:  ||..:.:...
plant   141 LSLSMIKVLIVDECHHAGGKHPYACIMREFYHKELNSGTSNVPRIFGMTASLVKTKGENLDSYWK 205

  Fly   187 KLKELEITYRGNIITVSDTKEMENVMLYATKPTEVM--VSFPHQEQVLTVTRLISAEIEKFYVSL 249
            |:.|||......:.|..:...:...:.::|...:..  :..|..::...|.:|....| |..:||
plant   206 KIHELETLMNSKVYTCENESVLAGFVPFSTPSFKYYQHIKIPSPKRASLVEKLERLTI-KHRLSL 269

  Fly   250 DLMNIGVQPIRRSKSLQCLRDPSKKSFVKQLFNDFLYQMKEYGIYAASIAIISLIVEFDIKRRQA 314
            ..:::....:          |..:|..:: :.:...|.:.:.||..|..|..||      ...|.
plant   270 GTLDLNSSTV----------DSVEKRLLR-ISSTLTYCLDDLGILLAQKAAQSL------SASQN 317

  Fly   315 ETLSVKLMHRTALTLCEKI-----RHLLVQKLQDMTYDDDDDNVNTEEVIMNFSTPKVQRFLMSL 374
            ::.....::..::.|.:|.     :..|.:..|.:.:...:.|.|.|..::...|      :..:
plant   318 DSFLWGELNMFSVALVKKFCSDASQEFLAEIPQGLNWSVANINGNAEAGLLTLKT------VCLI 376

  Fly   375 KVSFADKDPKDICCLVFVERRYTCKCIYGLLLNYIQSTPELRNVLTPQFMVGRNNISPDFESVLE 439
            :........::|.|::||:|..|...:..||...:   |...|..| :::.|.|       |.|:
plant   377 ETLLGYSSLENIRCIIFVDRVITAIVLESLLAEIL---PNCNNWKT-KYVAGNN-------SGLQ 430

  Fly   440 ---RKWQKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFILDPVKTFNMYVQSKGRARTTEAK 501
               ||.|...::.||.|..|:::.:|:||||:|||:||.|...||......::||:||||...:.
plant   431 NQTRKKQNEIVEDFRRGLVNIIVATSILEEGLDVQSCNLVIRFDPASNICSFIQSRGRARMQNSD 495

  Fly   502 FVLFTADKEREKTIQQIYQYRKAHNDIAEYLKDRVLEKTEPELYEIKGHFQDDID-PF--TNENG 563
            :::.....:. .|..::.:|......:.|...|..|....|        ..||.| |.  ....|
plant   496 YLMMVESGDL-LTQSRLMKYLSGGKRMREESLDHSLVPCPP--------LPDDSDEPLFRVESTG 551

  Fly   564 AVLLPNNALAILHRYCQTIPTDAFGFVIPWFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRD 628
            |.:..::::::::.||..:|:|.:....|.|.|             .|.:...::.:|.:|.:::
plant   552 ATVTLSSSVSLIYHYCSRLPSDEYFKPAPRFDV-------------NKDQGSCTLYLPKSCPVKE 603

  Fly   629 TIYSDPMDNVKTAKISAAFKACKVLYSLGELNERFVPKTLKERVASIADVHFEHWNKYGDSVTA- 692
            .   ....|.|..|.:...|||..|:.:|.|::..||                      |.|.| 
plant   604 V---KAEANNKVLKQAVCLKACIQLHKVGALSDHLVP----------------------DMVVAE 643

  Fly   693 TVNKADKSKDRTYKTECPLEFYDALPRVGEICYAYEIFLEPQFES-CEYTEHMYL---NLQTPRN 753
            ||::  |.:...|.||.|             || :...|..||.: .|.|.|.||   ...:|||
plant   644 TVSQ--KLEKIQYNTEQP-------------CY-FPPELVSQFSAQPETTYHFYLIRMKPNSPRN 692

  Fly   754 Y---AILLRNKLP----------RLAE-----MPLFSNQGKLHV---------RVANAPLEVIIQ 791
            :   .:||..::.          ||.:     ....|..|..|:         |.......|::.
plant   693 FHLNDVLLGTRVVLEDDIGNTSFRLEDHRGTIAVTLSYVGAFHLTQEEVLFCRRFQITLFRVLLD 757

  Fly   792 NSEQLELLHQFHGMVFRDILKIWHPFFVLDRRSKENSYLVVPLILGAGEQKCFDWELMTNF---- 852
            :|.: .|:...:|:..||.:.:              .||:|| ...:.|....|||::.:.    
plant   758 HSVE-NLMEALNGLHLRDGVAL--------------DYLLVP-STHSHETSLIDWEVIRSVNLTS 806

  Fly   853 RRLPQSHGSNVQQREQQPAPRPED-------FEGKIVTQWYANYDKPMLVTK-VHRELTPLSYME 909
            ..:.:.| .|............:|       .:..:|   |..::..:..|| |...|...|.:.
plant   807 HEVLEKH-ENCSTNGASRILHTKDGLFCTCVVQNALV---YTPHNGYVYCTKGVLNNLNGNSLLT 867

  Fly   910 K-NQQDKTYYEFTMSKYGNRIGDVVHKDKFMIEVRDLTEQLTFYVHNRGKFNAKSKAKMKVILIP 973
            | |..|:||.|:...::|.::..|   |:.::..|.:. .|..|:|...|...|...:..|.|.|
plant   868 KRNSGDQTYIEYYEERHGIQLNFV---DEPLLNGRHIF-TLHSYLHMAKKKKEKEHDREFVELPP 928

  Fly   974 ELCFNFNFP--GDLWLKLIFLPSILNRMYFLLHAEALRKRFNTYLNLHLLPFNGTDYMPRPLEID 1036
            |||.....|  .|:.....|:||::.|:..||                               |.
plant   929 ELCHVILSPISVDMIYSYTFIPSVMQRIESLL-------------------------------IA 962

  Fly  1037 YSLKRNVDPLGNVIPTEDIEEPKSLLEPMPTKSIEASVANLEITEFENPWQKYMEPVDLSRNLLS 1101
            |:||:::              ||                                          
plant   963 YNLKKSI--------------PK------------------------------------------ 971

  Fly  1102 TYPVELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPALMPSKPT 1166
                                                                 .|:|.:      
plant   972 -----------------------------------------------------VNIPTI------ 977

  Fly  1167 VRGKVKPLLILQKTVSKEHITPAEQGEFLAAITASSAADVFDMERLEILGDSFLKLSATLYLASK 1231
                                      :.|.|||.....|.|.:|.||.|||||||.:....|...
plant   978 --------------------------KVLEAITTKKCEDQFHLESLETLGDSFLKYAVCQQLFQH 1016

  Fly  1232 YSDWNEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQ---FTPRYTWLPPG-----ISLPHNV 1288
            ....:||.|:..|..::|  |::.|..... .|....|:   |.|: .|:.||     .||.::.
plant  1017 CHTHHEGLLSTKKDGMIS--NVMLCQFGCQ-QKLQGFIRDECFEPK-GWMVPGQSSAAYSLVNDT 1077

  Fly  1289 LALWRENPEFAKIIGPHNLRDLALGDEESLVKGNCSDINYNRFVEGCRANGQSFYAGADFSSEVN 1353
            |      ||                             :.|.:|...|                 
plant  1078 L------PE-----------------------------SRNIYVASRR----------------- 1090

  Fly  1354 FCVGLVTIPNKVIADTLEALLGVIVKNYGLQHAFKMLEYFKICRADIDKPLTQLLNLELGGKKMR 1418
                  .:..|.:||.:|:|:|..:...|...|...:.:..|                      :
plant  1091 ------NLKRKSVADVVESLIGAYLSEGGELAALMFMNWVGI----------------------K 1127

  Fly  1419 ANVNTTEID-------GFLINHYYLEKNLGYTFKDRRYLLQALTHPSYPTNRITGSYQELEFIGD 1476
            .:..||:|.       ..|:|..|:|..|.|:|:|:..|::||||.||....|...||.|||:||
plant  1128 VDFTTTKIQRDSPIQAEKLVNVGYMESLLNYSFEDKSLLVEALTHGSYMMPEIPRCYQRLEFLGD 1192

  Fly  1477 AILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVN 1541
            ::||:||:.::::....::||.|||:|||.|||...|.:.|:..||..||..:..|.:.||:.|:
plant  1193 SVLDYLITKHLYDKYPCLSPGLLTDMRSASVNNECYALVAVKANLHKHILYASHHLHKHISRTVS 1257

  Fly  1542 FQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNV 1606
                           ..|::.:|.|                                 |...:::
plant  1258 ---------------EFEQSSLQST---------------------------------FGWESDI 1274

  Fly  1607 DVPKALGDVLEALIAAVYLDCRDLQRTWEVIFNLFEPEL--QEFTRKVPINHIRQLVE--HKHAK 1667
            ..||.||||:|:|..|:::|.   ....||:|...:|.|  ......|.::.:|:|.|  .|...
plant  1275 SFPKVLGDVIESLAGAIFVDS---GYNKEVVFASIKPLLGCMITPETVKLHPVRELTELCQKWQF 1336

  Fly  1668 PVFSSPIVEGETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQQL 1717
            .:..:...:..||.|..:......|.|    .|:|..||..|.|..|..|
plant  1337 ELSKAKDFDSFTVEVKAKEMSFAHTAK----ASDKKMAKKLAYKEVLNLL 1382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-2NP_523778.2 MPH1 6..542 CDD:224036 146/555 (26%)
DEXDc 22..173 CDD:238005 60/154 (39%)
Dicer_PBD 241..343 CDD:277191 17/106 (16%)
HELICc <438..495 CDD:197757 24/59 (41%)
Dicer_dimer 572..665 CDD:281376 19/92 (21%)
PAZ 843..1004 CDD:198017 41/175 (23%)
RIBOc 1194..1391 CDD:238333 47/204 (23%)
Rnc 1433..1719 CDD:223644 83/289 (29%)
RIBOc 1448..1649 CDD:238333 59/202 (29%)
dsrm 1653..1717 CDD:278464 16/65 (25%)
DCL2NP_001189798.1 DEXDc 38..192 CDD:238005 61/156 (39%)
Helicase_C 382..489 CDD:278689 38/117 (32%)
Dicer_dimer 560..637 CDD:281376 19/92 (21%)
PAZ_CAF_like 807..937 CDD:239210 31/137 (23%)
RIBOc 980..1123 CDD:238333 47/204 (23%)
Rnc 1151..1384 CDD:223644 83/287 (29%)
RIBOc 1164..1318 CDD:238333 59/204 (29%)
DSRM 1323..1383 CDD:214634 17/64 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 113 1.000 Domainoid score I2031
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H135164
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57860
OrthoDB 1 1.010 - - D1337630at2759
OrthoFinder 1 1.000 - - FOG0002051
OrthoInspector 1 1.000 - - mtm1149
orthoMCL 1 0.900 - - OOG6_101152
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1728
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.690

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