Protein Alignment Dcr-2 and DCL2

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_566199.4
• Gene: DCL2 / 821300
• AraportID: AT3G03300
• Length: 1388
• Species: Arabidopsis thaliana
• Alignment Length: 1805
• Identity: 403/1805 - (22%)
• Similarity: 670/1805 - (37%)
• Gaps: 525/1805 - (29%)

  Fly     2 EDVEIKP----RGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALF 62
            :.|...|    |.||:..::...|.|.||:|.||||||.:||::|:.::..|.||...   ..:|
plant    14 DQVSASPLHFARSYQVEALEKAIKQNTIVFLETGSGKTLIAIMLLRSYAYLFRKPSPC---FCVF 75

  Fly    63 MCNTVELARQQAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVTQTY 127
            :...|.|..|||.|::..|:.|||.|.|:.|||.|....|..|:.|.:|||.|..:.||.:..::
plant    76 LVPQVVLVTQQAEALKMHTDLKVGMYWGDMGVDFWDSSTWKQEVDKYEVLVMTPAILLDALRHSF 140

  Fly   128 VALSSLSVVIIDECHHGTGHHPF----REFMRLFTIANQTKLPRVVGLTGVLI--KGNEITNVAT 186
            ::||.:.|:|:|||||..|.||:    |||......:..:.:||:.|:|..|:  ||..:.:...
plant   141 LSLSMIKVLIVDECHHAGGKHPYACIMREFYHKELNSGTSNVPRIFGMTASLVKTKGENLDSYWK 205

  Fly   187 KLKELEITYRGNIITVSDTKEMENVMLYATKPTEVM--VSFPHQEQVLTVTRLISAEIEKFYVSL 249
            |:.|||......:.|..:...:...:.::|...:..  :..|..::...|.:|....| |..:||
plant   206 KIHELETLMNSKVYTCENESVLAGFVPFSTPSFKYYQHIKIPSPKRASLVEKLERLTI-KHRLSL 269

  Fly   250 DLMNIGVQPIRRSKSLQCLRDPSKKSFVKQLFNDFLYQMKEYGIYAASIAIISLIVEFDIKRRQA 314
            ..:::....:          |..:|..:: :.:...|.:.:.||..|..|..||      ...|.
plant   270 GTLDLNSSTV----------DSVEKRLLR-ISSTLTYCLDDLGILLAQKAAQSL------SASQN 317

  Fly   315 ETLSVKLMHRTALTLCEKI-----RHLLVQKLQDMTYDDDDDNVNTEEVIMNFSTPKVQRFLMSL 374
            ::.....::..::.|.:|.     :..|.:..|.:.:...:.|.|.|..::...|      :..:
plant   318 DSFLWGELNMFSVALVKKFCSDASQEFLAEIPQGLNWSVANINGNAEAGLLTLKT------VCLI 376

  Fly   375 KVSFADKDPKDICCLVFVERRYTCKCIYGLLLNYIQSTPELRNVLTPQFMVGRNNISPDFESVLE 439
            :........::|.|::||:|..|...:..||...:   |...|..| :::.|.|       |.|:
plant   377 ETLLGYSSLENIRCIIFVDRVITAIVLESLLAEIL---PNCNNWKT-KYVAGNN-------SGLQ 430

  Fly   440 ---RKWQKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFILDPVKTFNMYVQSKGRARTTEAK 501
               ||.|...::.||.|..|:::.:|:||||:|||:||.|...||......::||:||||...:.
plant   431 NQTRKKQNEIVEDFRRGLVNIIVATSILEEGLDVQSCNLVIRFDPASNICSFIQSRGRARMQNSD 495

  Fly   502 FVLFTADKEREKTIQQIYQYRKAHNDIAEYLKDRVLEKTEPELYEIKGHFQDDID-PF--TNENG 563
            :::.....:. .|..::.:|......:.|...|..|....|        ..||.| |.  ....|
plant   496 YLMMVESGDL-LTQSRLMKYLSGGKRMREESLDHSLVPCPP--------LPDDSDEPLFRVESTG 551

  Fly   564 AVLLPNNALAILHRYCQTIPTDAFGFVIPWFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRD 628
            |.:..::::::::.||..:|:|.:....|.|.|             .|.:...::.:|.:|.:::
plant   552 ATVTLSSSVSLIYHYCSRLPSDEYFKPAPRFDV-------------NKDQGSCTLYLPKSCPVKE 603

  Fly   629 TIYSDPMDNVKTAKISAAFKACKVLYSLGELNERFVPKTLKERVASIADVHFEHWNKYGDSVTA- 692
            .   ....|.|..|.:...|||..|:.:|.|::..||                      |.|.|
plant   604 V---KAEANNKVLKQAVCLKACIQLHKVGALSDHLVP----------------------DMVVAE 643

  Fly   693 TVNKADKSKDRTYKTECPLEFYDALPRVGEICYAYEIFLEPQFES-CEYTEHMYL---NLQTPRN 753
            ||::  |.:...|.||.|             || :...|..||.: .|.|.|.||   ...:|||
plant   644 TVSQ--KLEKIQYNTEQP-------------CY-FPPELVSQFSAQPETTYHFYLIRMKPNSPRN 692

  Fly   754 Y---AILLRNKLP----------RLAE-----MPLFSNQGKLHV---------RVANAPLEVIIQ 791
            :   .:||..::.          ||.:     ....|..|..|:         |.......|::.
plant   693 FHLNDVLLGTRVVLEDDIGNTSFRLEDHRGTIAVTLSYVGAFHLTQEEVLFCRRFQITLFRVLLD 757

  Fly   792 NSEQLELLHQFHGMVFRDILKIWHPFFVLDRRSKENSYLVVPLILGAGEQKCFDWELMTNF---- 852
            :|.: .|:...:|:..||.:.:              .||:|| ...:.|....|||::.:.
plant   758 HSVE-NLMEALNGLHLRDGVAL--------------DYLLVP-STHSHETSLIDWEVIRSVNLTS 806

  Fly   853 RRLPQSHGSNVQQREQQPAPRPED-------FEGKIVTQWYANYDKPMLVTK-VHRELTPLSYME 909
            ..:.:.| .|............:|       .:..:|   |..::..:..|| |...|...|.:.
plant   807 HEVLEKH-ENCSTNGASRILHTKDGLFCTCVVQNALV---YTPHNGYVYCTKGVLNNLNGNSLLT 867

  Fly   910 K-NQQDKTYYEFTMSKYGNRIGDVVHKDKFMIEVRDLTEQLTFYVHNRGKFNAKSKAKMKVILIP 973
            | |..|:||.|:...::|.::..|   |:.::..|.:. .|..|:|...|...|...:..|.|.|
plant   868 KRNSGDQTYIEYYEERHGIQLNFV---DEPLLNGRHIF-TLHSYLHMAKKKKEKEHDREFVELPP 928

  Fly   974 ELCFNFNFP--GDLWLKLIFLPSILNRMYFLLHAEALRKRFNTYLNLHLLPFNGTDYMPRPLEID 1036
            |||.....|  .|:.....|:||::.|:..||                               |.
plant   929 ELCHVILSPISVDMIYSYTFIPSVMQRIESLL-------------------------------IA 962

  Fly  1037 YSLKRNVDPLGNVIPTEDIEEPKSLLEPMPTKSIEASVANLEITEFENPWQKYMEPVDLSRNLLS 1101
            |:||:::              ||
plant   963 YNLKKSI--------------PK------------------------------------------ 971

  Fly  1102 TYPVELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPALMPSKPT 1166
                                                                 .|:|.:
plant   972 -----------------------------------------------------VNIPTI------ 977

  Fly  1167 VRGKVKPLLILQKTVSKEHITPAEQGEFLAAITASSAADVFDMERLEILGDSFLKLSATLYLASK 1231
                                      :.|.|||.....|.|.:|.||.|||||||.:....|...
plant   978 --------------------------KVLEAITTKKCEDQFHLESLETLGDSFLKYAVCQQLFQH 1016

  Fly  1232 YSDWNEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQ---FTPRYTWLPPG-----ISLPHNV 1288
            ....:||.|:..|..::|  |::.|..... .|....|:   |.|: .|:.||     .||.::.
plant  1017 CHTHHEGLLSTKKDGMIS--NVMLCQFGCQ-QKLQGFIRDECFEPK-GWMVPGQSSAAYSLVNDT 1077

  Fly  1289 LALWRENPEFAKIIGPHNLRDLALGDEESLVKGNCSDINYNRFVEGCRANGQSFYAGADFSSEVN 1353
            |      ||                             :.|.:|...|
plant  1078 L------PE-----------------------------SRNIYVASRR----------------- 1090

  Fly  1354 FCVGLVTIPNKVIADTLEALLGVIVKNYGLQHAFKMLEYFKICRADIDKPLTQLLNLELGGKKMR 1418
                  .:..|.:||.:|:|:|..:...|...|...:.:..|                      :
plant  1091 ------NLKRKSVADVVESLIGAYLSEGGELAALMFMNWVGI----------------------K 1127

  Fly  1419 ANVNTTEID-------GFLINHYYLEKNLGYTFKDRRYLLQALTHPSYPTNRITGSYQELEFIGD 1476
            .:..||:|.       ..|:|..|:|..|.|:|:|:..|::||||.||....|...||.|||:||
plant  1128 VDFTTTKIQRDSPIQAEKLVNVGYMESLLNYSFEDKSLLVEALTHGSYMMPEIPRCYQRLEFLGD 1192

  Fly  1477 AILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVN 1541
            ::||:||:.::::....::||.|||:|||.|||...|.:.|:..||..||..:..|.:.||:.|:
plant  1193 SVLDYLITKHLYDKYPCLSPGLLTDMRSASVNNECYALVAVKANLHKHILYASHHLHKHISRTVS 1257

  Fly  1542 FQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNV 1606
                           ..|::.:|.|                                 |...:::
plant  1258 ---------------EFEQSSLQST---------------------------------FGWESDI 1274

  Fly  1607 DVPKALGDVLEALIAAVYLDCRDLQRTWEVIFNLFEPEL--QEFTRKVPINHIRQLVE--HKHAK 1667
            ..||.||||:|:|..|:::|.   ....||:|...:|.|  ......|.::.:|:|.|  .|...
plant  1275 SFPKVLGDVIESLAGAIFVDS---GYNKEVVFASIKPLLGCMITPETVKLHPVRELTELCQKWQF 1336

  Fly  1668 PVFSSPIVEGETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQQL 1717
            .:..:...:..||.|..:......|.|    .|:|..||..|.|..|..|
plant  1337 ELSKAKDFDSFTVEVKAKEMSFAHTAK----ASDKKMAKKLAYKEVLNLL 1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792	74/207 (36%)
		Dicer_PBD	241..343	CDD:277191	17/106 (16%)
		SF2_C_dicer	360..506	CDD:350189	42/148 (28%)
		Dicer_dimer	571..670	CDD:460900	21/98 (21%)
		PAZ	843..1004	CDD:198017	41/175 (23%)
		RIBOc	1194..1391	CDD:238333	47/204 (23%)
		RIBOc	1448..1649	CDD:238333	59/202 (29%)
		dsrm	1653..1717	CDD:425434	16/65 (25%)
DCL2	NP_566199.4	DEXHc_dicer	24..222	CDD:350792	73/200 (37%)
		SF2_C_dicer	371..500	CDD:350189	42/145 (29%)
		Dicer_dimer	559..637	CDD:460900	19/93 (20%)
		PAZ_CAF_like	807..937	CDD:239210	31/137 (23%)
		RIBOc	980..1123	CDD:238333	47/204 (23%)
		RIBOc	1164..1318	CDD:238333	59/204 (29%)
		DSRM_SF	1321..1382	CDD:444671	16/64 (25%)