DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-2 and DHX58

DIOPT Version :9

Sequence 1:NP_523778.2 Gene:Dcr-2 / 36993 FlyBaseID:FBgn0034246 Length:1722 Species:Drosophila melanogaster
Sequence 2:NP_077024.2 Gene:DHX58 / 79132 HGNCID:29517 Length:678 Species:Homo sapiens


Alignment Length:582 Identity:128/582 - (21%)
Similarity:240/582 - (41%) Gaps:106/582 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RGYQLRLV-DHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVELARQ 72
            |.||..:: ..|...|.|::||||:|||..|..|.||..:..|      |.:.:.:.|.|.|..|
Human     4 RSYQWEVIMPALEGKNIIIWLPTGAGKTRAAAYVAKRHLETVD------GAKVVVLVNRVHLVTQ 62

  Fly    73 QAMAVRRCTN--FKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVT----QTYVALS 131
            .....||..:  :.|....|:.|    .|..:....:.:.:|:.||::....:|    :.:|.|:
Human    63 HGEEFRRMLDGRWTVTTLSGDMG----PRAGFGHLARCHDLLICTAELLQMALTSPEEEEHVELT 123

  Fly   132 SLSVVIIDECHHGTGHHPFREFMRLF---TIANQTKLPRVVGLTGVLIKGNEITNVATKL----- 188
            ..|::::|||||......:...|..:   .:.....||:|:|||     .:..|..|:||     
Human   124 VFSLIVVDECHHTHKDTVYNVIMSQYLELKLQRAQPLPQVLGLT-----ASPGTGGASKLDGAIN 183

  Fly   189 KELEITYRGNIIT---VSDTKEMENVMLYATKPTEVMVSFPHQEQVLTVTRLISAEIEKFYVSLD 250
            ..|::.  .|:.|   :|.......:..::.:|.: ..:..|:........|:...:::.:..|:
Human   184 HVLQLC--ANLDTWCIMSPQNCCPQLQEHSQQPCK-QYNLCHRRSQDPFGDLLKKLMDQIHDHLE 245

  Fly   251 LMNIGVQPIRRSKSLQCLRDPSKKSFVKQLFNDFLYQMKEYGIYAASIAII-------------- 301
            :..:                  .:.|..|::...:.::.|    ||::|.:              
Human   246 MPEL------------------SRKFGTQMYEQQVVKLSE----AAALAGLQEQRVYALHLRRYN 288

  Fly   302 -SLIVEFDIKRRQAETLSVKLMHRTALT----LCEKIRHLLVQKLQDMTYDDDDDNVNTEEVIMN 361
             :|::...::...|........||..:|    ||.:.|.|.:        .||..|.........
Human   289 DALLIHDTVRAVDALAALQDFYHREHVTKTQILCAERRLLAL--------FDDRKNELAHLATHG 345

  Fly   362 FSTPKVQRFLMSLKVSFADKD-PKDICCLVFVERRYTCKCIYGLLLNYIQSTPELRNV-LTPQFM 424
            ...||::.....|:..|:..: |:.|   :|...|.:.   :.||| ::|....|:.| :..|.:
Human   346 PENPKLEMLEKILQRQFSSSNSPRGI---IFTRTRQSA---HSLLL-WLQQQQGLQTVDIRAQLL 403

  Fly   425 VGRNNISPDFESVLERKWQKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFILDPVKTFNMYV 489
            :|..|.|.  .:.:.::.|:..||:|:||..||::.:||.|||:|:..||.|.....:......|
Human   404 IGAGNSSQ--STHMTQRDQQEVIQKFQDGTLNLLVATSVAEEGLDIPHCNVVVRYGLLTNEISMV 466

  Fly   490 QSKGRARTTEAKFVLFTADKEREKTIQQIYQYRKAHNDIAEYLKDR---VLEKTEPELYEIK 548
            |::||||..::.:.....:..||..       |:..|:..|.|.::   .::|.:...|:.|
Human   467 QARGRARADQSVYAFVATEGSRELK-------RELINEALETLMEQAVAAVQKMDQAEYQAK 521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-2NP_523778.2 MPH1 6..542 CDD:224036 126/574 (22%)
DEXDc 22..173 CDD:238005 43/159 (27%)
Dicer_PBD 241..343 CDD:277191 16/120 (13%)
HELICc <438..495 CDD:197757 20/56 (36%)
Dicer_dimer 572..665 CDD:281376
PAZ 843..1004 CDD:198017
RIBOc 1194..1391 CDD:238333
Rnc 1433..1719 CDD:223644
RIBOc 1448..1649 CDD:238333
dsrm 1653..1717 CDD:278464
DHX58NP_077024.2 MPH1 2..542 CDD:224036 128/582 (22%)
DEXDc 18..170 CDD:238005 44/166 (27%)
DECH box 131..134 2/2 (100%)
MDA5_ID 227..345 CDD:277189 20/147 (14%)
Helicase_C 350..472 CDD:278689 37/130 (28%)
LGP2_C 552..664 CDD:276944
RNA-binding 572..655
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1337630at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.010

Return to query results.
Submit another query.