Protein Alignment Dcr-2 and MRPL44

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_075066.1
• Gene: MRPL44 / 65080
• HGNCID: 16650
• Length: 332
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 53/264 - (20%)
• Similarity: 88/264 - (33%)
• Gaps: 83/264 - (31%)

  Fly  1519 HRLHFFILAENAKLSEIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLD---------DEL 1574
            |||.     ||..|..:.:.|||         :.|::  .|||..|...::.:         .||
Human    77 HRLQ-----ENFSLDLLKTAFVN---------SCYIK--SEEAKRQQLGIEKEAVLLNLKSNQEL 125

  Fly  1575 DMTELPHANKCISQEAE---KGVPPKG------------------------EFNMSTNVDVPKA- 1611
            .......:..|::|..|   ..:|.:|                        :..:|....||.|
Human   126 SEQGTSFSQTCLTQFLEDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQLTLSEEFPVPPAV 190

  Fly  1612 LGDVLEALIAAV-------------------YLDCRDLQRTWEVI--FNLFEPELQEFTRKVPIN 1655
            |.....|:|.|:                   .:..::|...|::|  ..|...||::.....|.:
Human   191 LQQTFFAVIGALLQSSGPERTALFIRDFLITQMTGKELFEMWKIINPMGLLVEELKKRNVSAPES 255

  Fly  1656 HIRQLVEHKHAKPVF-------SSPIVE--GETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAK 1711
            .:.:......|.|::       ...|.|  ||||:|:.:........|:|||..|:.....|..|
Human   256 RLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKLYGFTENRRPWNYSKPK 320

  Fly  1712 HALQ 1715
            ..|:
Human   321 ETLR 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792
		Dicer_PBD	241..343	CDD:277191
		SF2_C_dicer	360..506	CDD:350189
		Dicer_dimer	571..670	CDD:460900
		PAZ	843..1004	CDD:198017
		RIBOc	1194..1391	CDD:238333
		RIBOc	1448..1649	CDD:238333	35/187 (19%)
		dsrm	1653..1717	CDD:425434	18/72 (25%)
MRPL44	NP_075066.1	Rnc	<138..304	CDD:440336	28/165 (17%)
		DSRM_MRPL44	225..307	CDD:380703	18/81 (22%)