DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dcr-2 and MRPL44

DIOPT Version :9

Sequence 1:NP_523778.2 Gene:Dcr-2 / 36993 FlyBaseID:FBgn0034246 Length:1722 Species:Drosophila melanogaster
Sequence 2:NP_075066.1 Gene:MRPL44 / 65080 HGNCID:16650 Length:332 Species:Homo sapiens


Alignment Length:264 Identity:53/264 - (20%)
Similarity:88/264 - (33%) Gaps:83/264 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1519 HRLHFFILAENAKLSEIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLD---------DEL 1574
            |||.     ||..|..:.:.|||         :.|::  .|||..|...::.:         .||
Human    77 HRLQ-----ENFSLDLLKTAFVN---------SCYIK--SEEAKRQQLGIEKEAVLLNLKSNQEL 125

  Fly  1575 DMTELPHANKCISQEAE---KGVPPKG------------------------EFNMSTNVDVPKA- 1611
            .......:..|::|..|   ..:|.:|                        :..:|....||.| 
Human   126 SEQGTSFSQTCLTQFLEDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQLTLSEEFPVPPAV 190

  Fly  1612 LGDVLEALIAAV-------------------YLDCRDLQRTWEVI--FNLFEPELQEFTRKVPIN 1655
            |.....|:|.|:                   .:..::|...|::|  ..|...||::.....|.:
Human   191 LQQTFFAVIGALLQSSGPERTALFIRDFLITQMTGKELFEMWKIINPMGLLVEELKKRNVSAPES 255

  Fly  1656 HIRQLVEHKHAKPVF-------SSPIVE--GETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAK 1711
            .:.:......|.|::       ...|.|  ||||:|:.:........|:|||..|:.....|..|
Human   256 RLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKLYGFTENRRPWNYSKPK 320

  Fly  1712 HALQ 1715
            ..|:
Human   321 ETLR 324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-2NP_523778.2 MPH1 6..542 CDD:224036
DEXDc 22..173 CDD:238005
Dicer_PBD 241..343 CDD:277191
HELICc <438..495 CDD:197757
Dicer_dimer 572..665 CDD:281376
PAZ 843..1004 CDD:198017
RIBOc 1194..1391 CDD:238333
Rnc 1433..1719 CDD:223644 53/264 (20%)
RIBOc 1448..1649 CDD:238333 35/187 (19%)
dsrm 1653..1717 CDD:278464 18/72 (25%)
MRPL44NP_075066.1 RIBOc 117..222 CDD:412266 15/104 (14%)
DSRM_MRPL44 225..307 CDD:380703 18/81 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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