DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dcr-2 and drosha

DIOPT Version :9

Sequence 1:NP_523778.2 Gene:Dcr-2 / 36993 FlyBaseID:FBgn0034246 Length:1722 Species:Drosophila melanogaster
Sequence 2:NP_001103942.1 Gene:drosha / 567505 ZFINID:ZDB-GENE-070209-23 Length:1289 Species:Danio rerio


Alignment Length:1301 Identity:245/1301 - (18%)
Similarity:402/1301 - (30%) Gaps:512/1301 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   597 LQEDERDRIFGVSAKGKHVIS-----------------------INMP--VNCMLRDTIYS-DPM 635
            ::||:..|..|.|:..:..::                       ::.|  :.|...:..|| |||
Zfish   282 VEEDKERRTDGSSSSRERSVNSSRSREAEEITIDRHEEDRGQEELHKPAWIRCTHAENYYSNDPM 346

  Fly   636 DNVKTAKISAAFKACKVLY-----SLGELNERF--------VPKT-------------------- 667
            |.|..:.:....| .:.||     .||:..||.        .|||                    
Zfish   347 DQVGDSTVVGTSK-LRDLYERFEEELGKRQERAKSIRPKWEPPKTKLDQDQDESSSESECESDGG 410

  Fly   668 ------------------LKERVASIADVHFEHW-NKYGDSVTATVNKADKSKDRT------YKT 707
                              :|.:.|....:|.|.| |..|......:.|......||      |..
Zfish   411 GSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPG 475

  Fly   708 ECPLEFYDALPRVGEICYAYEI-------FLEPQFESCEYTEHMYL------NLQTPRNYAILLR 759
            |.|::....:.......:.|.|       ||..:....||.:|.||      ...||        
Zfish   476 EQPVKQCRPMNNNAGKLFHYRITVSPPTNFLTDRPTVIEYDDHEYLFEGFSCFSHTP-------- 532

  Fly   760 NKLPRLAEMPL-----FSNQGKLHVRVANAPLEVIIQNSEQLELLHQFHGMVFRDILKI--WHPF 817
                 |..:||     |:....:|.....||....::.   |||   |...:|:|||::  |:  
Zfish   533 -----LTSIPLCRVIRFNIDYTIHFIEEMAPENYCVKG---LEL---FSSYLFKDILELYDWN-- 584

  Fly   818 FVLDRRSKENSYLVVPLILGAGEQKCFDWELMTNFRRLPQSHGSNVQQREQQPAPRPEDFEGKIV 882
             :.|  .:|||    ||       .|..:..|..|.|.....|..|....|             |
Zfish   585 -LTD--PEENS----PL-------GCQRFHFMPRFVRFLPDGGKEVLSMHQ-------------V 622

  Fly   883 TQWYANYDKPMLVTKVHRELTPLSYMEKNQQDKTYYEFTMSKYGNRIGDVVHKDKFMIEVRDLTE 947
            ..:..:..||::   ...|:..:...|         |....||......::..:..|.......:
Zfish   623 LLYLLHSSKPLV---PEEEIANMLQWE---------ELEWQKYAEECKGMIVTNPGMKPSSVRID 675

  Fly   948 QLTFYVHNRGKFNAKSKAKMKVILIPELCF------NFNFPGD-----LWLKLIFLPSIL----- 996
            ||     :|.:||:      .||..|.:..      ..::.||     ||...:.|..:|     
Zfish   676 QL-----DREQFNS------SVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPK 729

  Fly   997 ----NRMYFLLHAEALRK--RFNTYLNLHLLPFNGTDYMPRPLEIDYS--------LKRNVDPLG 1047
                ::...:...|||:|  :.||              |.|.:.::.|        ::.:|....
Zfish   730 VKQIDKQKLMQREEALQKIRQKNT--------------MRREVTVELSSQGFWKTGIRSDVCQHA 780

  Fly  1048 NVIP--TEDIEEPKSLLEPMPTKSI-----EASVANLEITEFENPWQKYMEPVDLSRNLLSTYPV 1105
            .::|  |..|...:.|:.  ..|.|     |..:..|.:|...:.....|.| |.:||.||.   
Zfish   781 MMLPVLTHHIRYHQCLMH--LDKLIGYMFKERCLLQLAMTHPSHHLNFGMNP-DHARNSLSN--- 839

  Fly  1106 ELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPALMPSKPTVRGK 1170
                         |.:.:..:.|::.     .||     |..:....|..|:.:.:       |:
Zfish   840 -------------CGIRQPKYGDRKV-----HHM-----YMRKKGINTLINIMSRL-------GQ 874

  Fly  1171 VKPLLILQKTVSKEHITPAEQGEFLAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDW 1235
            ..|                            |.:.:...||||.|||:.::...:::|...:...
Zfish   875 DDP----------------------------SPSRINHNERLEFLGDAVVEFLTSVHLYHLFPSL 911

  Fly  1236 NEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAK 1300
            .||.|...::.:|.|::|      |.:.|.|...:|                  .|:...|:..:
Zfish   912 EEGGLATYRTAIVQNQHL------AMLAKKLELDRF------------------MLYAHGPDLCR 952

  Fly  1301 IIGPHNLRDLALGDEESLVKGNCSDINYNRFVEGCRANGQSFYAGADFSSEVNFCVGLVTIPNKV 1365
            .                      ||:.:                                    .
Zfish   953 E----------------------SDLRH------------------------------------A 959

  Fly  1366 IADTLEALLGVIVKNYGLQHAFKMLEYFKICRAD--------------IDKPLTQLLNLELGGKK 1416
            :|:..|||:|.:....||:.|..:.........|              :.:|||.          
Zfish   960 MANCFEALIGAVYLEGGLEEAKDLFGRLLFNTEDMREVWLNYPPHPLQVQEPLTD---------- 1014

  Fly  1417 MRANVNTTEIDGFLINHYYLEKNLGYTFKDRRYLLQALTHPSYPTNRIT-GSYQELEFIGDAILD 1480
             |..:.::.:...|.|   .|..:|..|...|.|.:|.|..:...|.:| |..|.:||:||:|:.
Zfish  1015 -RQLIESSPVLQKLTN---FEDAIGVLFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQ 1075

  Fly  1481 FLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVNFQES 1545
            .:.:.|:|.:....:.|.||.|||:||||.|                 .||::|.:.       .
Zfish  1076 LVATEYLFIHFPDHHEGHLTLLRSSLVNNRT-----------------QAKVAEELG-------M 1116

  Fly  1546 QGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNVDVPK 1610
            |...:||                      |.|:.|.|.:                        .|
Zfish  1117 QEFAITN----------------------DKTKRPVALR------------------------TK 1135

  Fly  1611 ALGDVLEALIAAVYLDCRDLQRTWEVIFNLFEPELQEFTRK------------------------ 1651
            .|.|:||:.|||:|:| :||:.....:...|.|.|:||...                        
Zfish  1136 TLADLLESFIAALYID-KDLEFVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEP 1199

  Fly  1652 -VPINHIRQLVEHKHAKPVFSSPIVEGETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQ 1715
             :|:....|.|...||:....:...:||  .:.|            |.|.:..||::.||..||:
Zfish  1200 DIPLYKTLQTVGPSHARTYTVAVYFKGE--RIGC------------GKGPSIQQAEMGAAMDALE 1250

  Fly  1716 Q 1716
            :
Zfish  1251 K 1251

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-2NP_523778.2 MPH1 6..542 CDD:224036
DEXDc 22..173 CDD:238005
Dicer_PBD 241..343 CDD:277191
HELICc <438..495 CDD:197757
Dicer_dimer 572..665 CDD:281376 21/106 (20%)
PAZ 843..1004 CDD:198017 30/180 (17%)
RIBOc 1194..1391 CDD:238333 31/196 (16%)
Rnc 1433..1719 CDD:223644 72/310 (23%)
RIBOc 1448..1649 CDD:238333 52/201 (26%)
dsrm 1653..1717 CDD:278464 16/64 (25%)
droshaNP_001103942.1 WWbp <14..63 CDD:304964
DUF1777 204..>320 CDD:285811 5/37 (14%)
PRP38_assoc 206..308 CDD:289628 5/25 (20%)
RIBOc 877..989 CDD:238333 32/221 (14%)
rnc 1025..1253 CDD:234633 74/315 (23%)
RIBOc 1042..1174 CDD:238333 53/202 (26%)
DSRM 1181..1252 CDD:214634 16/85 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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