Protein Alignment Dcr-2 and drosha

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_001103942.1
• Gene: drosha / 567505
• ZFINID: ZDB-GENE-070209-23
• Length: 1289
• Species: Danio rerio
• Alignment Length: 1301
• Identity: 245/1301 - (18%)
• Similarity: 402/1301 - (30%)
• Gaps: 512/1301 - (39%)

  Fly   597 LQEDERDRIFGVSAKGKHVIS-----------------------INMP--VNCMLRDTIYS-DPM 635
            ::||:..|..|.|:..:..::                       ::.|  :.|...:..|| |||
Zfish   282 VEEDKERRTDGSSSSRERSVNSSRSREAEEITIDRHEEDRGQEELHKPAWIRCTHAENYYSNDPM 346

  Fly   636 DNVKTAKISAAFKACKVLY-----SLGELNERF--------VPKT-------------------- 667
            |.|..:.:....| .:.||     .||:..||.        .|||
Zfish   347 DQVGDSTVVGTSK-LRDLYERFEEELGKRQERAKSIRPKWEPPKTKLDQDQDESSSESECESDGG 410

  Fly   668 ------------------LKERVASIADVHFEHW-NKYGDSVTATVNKADKSKDRT------YKT 707
                              :|.:.|....:|.|.| |..|......:.|......||      |..
Zfish   411 GSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPG 475

  Fly   708 ECPLEFYDALPRVGEICYAYEI-------FLEPQFESCEYTEHMYL------NLQTPRNYAILLR 759
            |.|::....:.......:.|.|       ||..:....||.:|.||      ...||
Zfish   476 EQPVKQCRPMNNNAGKLFHYRITVSPPTNFLTDRPTVIEYDDHEYLFEGFSCFSHTP-------- 532

  Fly   760 NKLPRLAEMPL-----FSNQGKLHVRVANAPLEVIIQNSEQLELLHQFHGMVFRDILKI--WHPF 817
                 |..:||     |:....:|.....||....::.   |||   |...:|:|||::  |:
Zfish   533 -----LTSIPLCRVIRFNIDYTIHFIEEMAPENYCVKG---LEL---FSSYLFKDILELYDWN-- 584

  Fly   818 FVLDRRSKENSYLVVPLILGAGEQKCFDWELMTNFRRLPQSHGSNVQQREQQPAPRPEDFEGKIV 882
             :.|  .:|||    ||       .|..:..|..|.|.....|..|....|             |
Zfish   585 -LTD--PEENS----PL-------GCQRFHFMPRFVRFLPDGGKEVLSMHQ-------------V 622

  Fly   883 TQWYANYDKPMLVTKVHRELTPLSYMEKNQQDKTYYEFTMSKYGNRIGDVVHKDKFMIEVRDLTE 947
            ..:..:..||::   ...|:..:...|         |....||......::..:..|.......:
Zfish   623 LLYLLHSSKPLV---PEEEIANMLQWE---------ELEWQKYAEECKGMIVTNPGMKPSSVRID 675

  Fly   948 QLTFYVHNRGKFNAKSKAKMKVILIPELCF------NFNFPGD-----LWLKLIFLPSIL----- 996
            ||     :|.:||:      .||..|.:..      ..::.||     ||...:.|..:|
Zfish   676 QL-----DREQFNS------SVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPK 729

  Fly   997 ----NRMYFLLHAEALRK--RFNTYLNLHLLPFNGTDYMPRPLEIDYS--------LKRNVDPLG 1047
                ::...:...|||:|  :.||              |.|.:.::.|        ::.:|....
Zfish   730 VKQIDKQKLMQREEALQKIRQKNT--------------MRREVTVELSSQGFWKTGIRSDVCQHA 780

  Fly  1048 NVIP--TEDIEEPKSLLEPMPTKSI-----EASVANLEITEFENPWQKYMEPVDLSRNLLSTYPV 1105
            .::|  |..|...:.|:.  ..|.|     |..:..|.:|...:.....|.| |.:||.||.
Zfish   781 MMLPVLTHHIRYHQCLMH--LDKLIGYMFKERCLLQLAMTHPSHHLNFGMNP-DHARNSLSN--- 839

  Fly  1106 ELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPALMPSKPTVRGK 1170
                         |.:.:..:.|::.     .||     |..:....|..|:.:.:       |:
Zfish   840 -------------CGIRQPKYGDRKV-----HHM-----YMRKKGINTLINIMSRL-------GQ 874

  Fly  1171 VKPLLILQKTVSKEHITPAEQGEFLAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDW 1235
            ..|                            |.:.:...||||.|||:.::...:::|...:...
Zfish   875 DDP----------------------------SPSRINHNERLEFLGDAVVEFLTSVHLYHLFPSL 911

  Fly  1236 NEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAK 1300
            .||.|...::.:|.|::|      |.:.|.|...:|                  .|:...|:..:
Zfish   912 EEGGLATYRTAIVQNQHL------AMLAKKLELDRF------------------MLYAHGPDLCR 952

  Fly  1301 IIGPHNLRDLALGDEESLVKGNCSDINYNRFVEGCRANGQSFYAGADFSSEVNFCVGLVTIPNKV 1365
            .                      ||:.:                                    .
Zfish   953 E----------------------SDLRH------------------------------------A 959

  Fly  1366 IADTLEALLGVIVKNYGLQHAFKMLEYFKICRAD--------------IDKPLTQLLNLELGGKK 1416
            :|:..|||:|.:....||:.|..:.........|              :.:|||.
Zfish   960 MANCFEALIGAVYLEGGLEEAKDLFGRLLFNTEDMREVWLNYPPHPLQVQEPLTD---------- 1014

  Fly  1417 MRANVNTTEIDGFLINHYYLEKNLGYTFKDRRYLLQALTHPSYPTNRIT-GSYQELEFIGDAILD 1480
             |..:.::.:...|.|   .|..:|..|...|.|.:|.|..:...|.:| |..|.:||:||:|:.
Zfish  1015 -RQLIESSPVLQKLTN---FEDAIGVLFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQ 1075

  Fly  1481 FLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVNFQES 1545
            .:.:.|:|.:....:.|.||.|||:||||.|                 .||::|.:.       .
Zfish  1076 LVATEYLFIHFPDHHEGHLTLLRSSLVNNRT-----------------QAKVAEELG-------M 1116

  Fly  1546 QGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNVDVPK 1610
            |...:||                      |.|:.|.|.:                        .|
Zfish  1117 QEFAITN----------------------DKTKRPVALR------------------------TK 1135

  Fly  1611 ALGDVLEALIAAVYLDCRDLQRTWEVIFNLFEPELQEFTRK------------------------ 1651
            .|.|:||:.|||:|:| :||:.....:...|.|.|:||...
Zfish  1136 TLADLLESFIAALYID-KDLEFVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEP 1199

  Fly  1652 -VPINHIRQLVEHKHAKPVFSSPIVEGETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQ 1715
             :|:....|.|...||:....:...:||  .:.|            |.|.:..||::.||..||:
Zfish  1200 DIPLYKTLQTVGPSHARTYTVAVYFKGE--RIGC------------GKGPSIQQAEMGAAMDALE 1250

  Fly  1716 Q 1716
            :
Zfish  1251 K 1251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792
		Dicer_PBD	241..343	CDD:277191
		SF2_C_dicer	360..506	CDD:350189
		Dicer_dimer	571..670	CDD:460900	24/149 (16%)
		PAZ	843..1004	CDD:198017	30/180 (17%)
		RIBOc	1194..1391	CDD:238333	31/196 (16%)
		RIBOc	1448..1649	CDD:238333	52/201 (26%)
		dsrm	1653..1717	CDD:425434	16/64 (25%)
drosha	NP_001103942.1	SF-CC1	213..>369	CDD:273721	17/87 (20%)
		RIBOc	877..989	CDD:238333	32/221 (14%)
		Rnc	1025..1253	CDD:440336	74/315 (23%)