Protein Alignment Dcr-2 and Dcr-1

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Alignment Length: 2400
• Identity: 518/2400 - (21%)
• Similarity: 836/2400 - (34%)
• Gaps: 863/2400 - (35%)

  Fly     8 PRGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVELARQ 72
            ||.:|:.|:....:.|.|:.|...|.|.|:|:.:|    |:..:.....|:.:::      |:.:
  Fly    17 PRDFQVELLATAYERNTIICLGHRSSKEFIALKLL----QELSRRARRHGRVSVY------LSCE 71

  Fly    73 QAMAVRRCTNFKVGFYVGEQGVDDWTR---------GMWSDEIKKNQVLVGTAQVFLDMVTQTYV 128
            ...:...|:.:.:..::.:..|  |..         ..|:|    ..|.:...:.||.::....:
  Fly    72 VGTSTEPCSIYTMLTHLTDLRV--WQEQPDMQIPFDHCWTD----YHVSILRPEGFLYLLETREL 130

  Fly   129 ALSSLSVVIIDECHHGTGHHPFRE-FMRLFTIANQTKLPRVVGLTGVL-IKGNEITNVATKLKEL 191
            .|||:.::::::||....:...|. |......|.....||::||.|.| ..|.|:..::..|..|
  Fly   131 LLSSVELIVLEDCHDSAVYQRIRPLFENHIMPAPPADRPRILGLAGPLHSAGCELQQLSAMLATL 195

  Fly   192 EITYRGNIITVSDTKEMENVMLYATKPTEVMVS-FPHQEQVLTVTRLISAEIEKFYVSLDLMNIG 255
            |.:....|.|.||   :..|:.|.::|.|.:|. .|.:...|:   |:.|::...:.|. |::..
  Fly   196 EQSVLCQIETASD---IVTVLRYCSRPHEYIVQCAPFEMDELS---LVLADVLNTHKSF-LLDHR 253

  Fly   256 VQPIR---RSKSLQCLRD-PSKKSFVKQLFNDFLYQMKEYGIYAASIAIISLIVEFDIKRRQA-- 314
            ..|..   ..:.:..|:| |..|.....:.|..|..:.|.|.:..              :|.|
  Fly   254 YDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCT--------------QRAAHH 304

  Fly   315 -----ETLSVKLMHR----------TAL----TLCEKI--RHLLVQKLQDMTYDDDDDNVNTEEV 358
                 |.|.||..|.          |||    :|||..  |||             ....::.:.
  Fly   305 FYQCNEKLKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHL-------------GSGSDSRQT 356

  Fly   359 IMNFSTPKVQRFLMSLK---------------------------------------VSFADKDPK 384
            |..:|:|||:|.|.:|:                                       |...|:.|.
  Fly   357 IERYSSPKVRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADFNRLSHTLESKCRMVDQMDQPPT 421

  Fly   385 D---------------------------------------------------------------- 385
            :
  Fly   422 ETRALVATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDH 486

  Fly   386 ------ICCLVFVERRYTCKCIYGLLLNYIQSTPELRNVLTPQFMVGR--NNISPDFESVLERKW 442
                  :|.|::..:.:|.:.::.||....:..|:|: .|..|:...|  :..:...|:.||.:.
  Fly   487 NDGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLK-FLRCQYTTDRVADPTTEPKEAELEHRR 550

  Fly   443 QKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFILDPVKTFNMYVQSKGRARTTEAKFVLFTA 507
            |:..:::||..:.|::|.:|||||||||..||.|...||..|:..|||.|||||...|..|:..|
  Fly   551 QEEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVA 615

  Fly   508 DKEREKTIQQI------YQYRKAHNDIAE-----------------------------YLKDRVL 537
            ...:..|:..:      ::|..|..|..|                             .|...|.
  Fly   616 PSYKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVF 680

  Fly   538 EKTEPELYEIK-GHFQDD------IDPFTNENGAVLLPN-------------------------- 569
            .|..|...:|| ...||:      :|...:.:.||.:.|
  Fly   681 SKQPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPE 745

  Fly   570 ----------------------------------------------------------------- 569
                                                                             
  Fly   746 DTSDTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRP 810

  Fly   570 -------------NALAILHRYCQTIPTDAFGFVIPWFHVLQEDERDRIFGVSAKGKHVISINMP 621
                         :|:|::::||..:|:|.|..:.    .|....|:...||:.   ...::.:|
  Fly   811 KPHLLTGASVDLGSAIALVNKYCARLPSDTFTKLT----ALWRCTRNERAGVTL---FQYTLRLP 868

  Fly   622 VNCMLRDTIYSDPMDNVKTAKISAAFKACKVLYSLGELNERFVP------KTLK----------- 669
            :|..|:..|...||.....|:..||.:||..|:.:|||:::..|      :.|:
  Fly   869 INSPLKHDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPE 933

  Fly   670 -ERVASIADVHFEHWNKYGDSVTATVNKADKSKDRTYKTECPLEFYDALPRVGEICYAYEIFLEP 733
             |::..::|               ........:.:.|......||.|..|..|..||.|.|.|..
  Fly   934 DEQIVQLSD---------------EPRPGTTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTL 983

  Fly   734 QFESCEYTEH-------MYLNLQTPRNYAILLRNKLPRLAEMPLFSNQGKLHVRVANAPLEVIIQ 791
            |   |...|.       :|......:.:.||...::|:|:...:|:..|::.|.:..|. |.:|.
  Fly   984 Q---CPIPEEQNTRGRKIYPPEDAQQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAK-ERVIL 1044

  Fly   792 NSEQLELLHQFHGMVFRDILKIWHPFFVLDRRSKENSYLVVPLILGAGEQKCFDWELMTNFRRLP 856
            .|||:..::.|....|.::|::.....:.|..|.||...:||.:......|..||:    |..|.
  Fly  1045 TSEQIVCINGFLNYTFTNVLRLQKFLMLFDPDSTENCVFIVPTVKAPAGGKHIDWQ----FLELI 1105

  Fly   857 QSHGSNV------QQREQQPAPRPEDFEGKIVTQWYANYDKP--MLVTKVHRELTPLSYMEKNQQ 913
            |::|:.:      ::|:.||.. |:.|:..:|..||.|.|:|  ..|.::...|:|||....:..
  Fly  1106 QANGNTMPRAVPDEERQAQPFD-PQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNY 1169

  Fly   914 DKTYYEFTMSKYGNRIGDVVHKDKFMIEVRDLTEQLTF----YVHNRG----------KFNAKSK 964
             :|:..:.:.|||..|.:.   .:.:::|...:.:|.|    ||:.:|          |...:..
  Fly  1170 -RTFKHYYLVKYGLTIQNT---SQPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKREN 1230

  Fly   965 AKMKVILIPELCFNFNFPGDLWLKLIFLPSILNRMYFLLHAEALRKRFNTYLNLHLLPFNGTDYM 1029
            .:.|.||:||||....||..||...:.||.||.|:..||.|:.:||:.:..|.|........|:.
  Fly  1231 LEQKQILVPELCTVHPFPASLWRTAVCLPCILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFE 1295

  Fly  1030 PRPLEIDYSL----------KRNVDPLGNVIPTEDIEEPKSLLEPMPTK------------SIEA 1072
            ...|:..:||          |:......:.|..:|:.:    :|..||.            .:|.
  Fly  1296 WPMLDFGWSLSEVLKKSRESKQKESLKDDTINGKDLAD----VEKKPTSEETQLDKDSKDDKVEK 1356

  Fly  1073 SVANLEITEFENPWQKYMEPVDLSRNLLSTYPVELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQF 1137
            |...| |.|.|   :|..|..|.         :|:..:.:....::...|:.| :|::    :.|
  Fly  1357 SAIEL-IIEGE---EKLQEADDF---------IEIGTWSNDMADDIASFNQED-DDED----DAF 1403

  Fly  1138 HMPT--GNI--------YGNRT-----------------PAKTNANVPALMPSKPT--------- 1166
            |:|.  .|:        ||:.|                 ..|......|..|:|||
  Fly  1404 HLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNS 1468

  Fly  1167 -----------------------------------------------------VRGKVKPLLILQ 1178
                                                                 |..:.|.|.|:|
  Fly  1469 LGSSYDDDDNAGPLNYMHHNYSSDDDDVADDIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQ 1533

  Fly  1179 KTVSKEH-------------------------------------------ITPAEQ--------- 1191
            .|.:.|.                                           :.|.:|
  Fly  1534 ATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDA 1598

  Fly  1192 --------------------------------------------------------------GE- 1193
                                                                          |:
  Fly  1599 AEAQVAKVSMMELLKQLLPYVNEDVLAKKLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDS 1663

  Fly  1194 --------------------------------------------------------------FLA 1196
                                                                          .|.
  Fly  1664 FDNYNDHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGFSFDRQPDLVGHPGPSPSIILQ 1728

  Fly  1197 AITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEGTLTEVKSKLVSNRNLLFCLIDAD 1261
            |:|.|:|.|..::||||.:||||||.:.|.||...|.:.:||.|:.::||.|:|.||........
  Fly  1729 ALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKR 1793

  Fly  1262 IPKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAKIIGPH-NLRDL--------------- 1310
            :.:.:...:|.|...||||...:|..:.....|    |||...| .|.||
  Fly  1794 LGEYMIATKFEPHDNWLPPCYYVPKELEKALIE----AKIPTHHWKLADLLDIKNLSSVQICEMV 1854

  Fly  1311 -----ALGDEES--LVKGNCSDINYNRFVEGCRANGQSFYAGADFSSEVNF-CVGLVTIPNKVIA 1367
                 |||.|::  ...|...|.|     :.|.          |||..:.: .|...:||:|.||
  Fly  1855 REKADALGLEQNGGAQNGQLDDSN-----DSCN----------DFSCFIPYNLVSQHSIPDKSIA 1904

  Fly  1368 DTLEALLGVIVKNYGLQHAFKMLEYFKICRADIDKPLTQLLNLELGG----------KKMRANV- 1421
            |.:|||:|..:...|.:.|...:.:..: |.   .|:|:.|:   ||          |....||
  Fly  1905 DCVEALIGAYLIECGPRGALLFMAWLGV-RV---LPITRQLD---GGNQEQRIPGSTKPNAENVV 1962

  Fly  1422 -------------------NTTEIDGFLINHYYLEKNLGYTFKDRRYLLQALTHPSYPTNRITGS 1467
                               .|.|:|..|......|::|||.|:||.|||||:||.||..||:|..
  Fly  1963 TVYGAWPTPRSPLLHFAPNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDC 2027

  Fly  1468 YQELEFIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKL 1532
            ||.|||:|||:||:||:.:::|:..:.:|||||||||||||||..|.:.|||..|.|....:..|
  Fly  2028 YQRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGL 2092

  Fly  1533 SEIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPK 1597
            :::|.:||..|:..||.::....:|.||        :.||..|
  Fly  2093 NDVIDRFVRIQQENGHCISEEYYLLSEE--------ECDDAED---------------------- 2127

  Fly  1598 GEFNMSTNVDVPKALGDVLEALIAAVYLDCR-DLQRTWEVIFNLFEPELQEFTRKVPINHIRQLV 1661
                    |:||||||||.|::..|::||.. .|...|.|..|:..||:::|:..||.:.||:|:
  Fly  2128 --------VEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNMMSPEIEQFSNSVPKSPIRELL 2184

  Fly  1662 EHKHAKPVFSSP--IVEGETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQQLSK 1719
            |.:.....|..|  :.:|..|.|:....| :.|.:  |.|.|...||.:|||.||:||.|
  Fly  2185 ELEPETAKFGKPEKLADGRRVRVTVDVFC-KGTFR--GIGRNYRIAKCTAAKCALRQLKK 2241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792	44/206 (21%)
		Dicer_PBD	241..343	CDD:277191	27/128 (21%)
		SF2_C_dicer	360..506	CDD:350189	53/256 (21%)
		Dicer_dimer	571..670	CDD:460900	28/116 (24%)
		PAZ	843..1004	CDD:198017	51/182 (28%)
		RIBOc	1194..1391	CDD:238333	68/220 (31%)
		RIBOc	1448..1649	CDD:238333	78/201 (39%)
		dsrm	1653..1717	CDD:425434	22/65 (34%)
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120	44/206 (21%)
		Dicer_PBD	240..344	CDD:277191	24/118 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819	43/124 (35%)
		Dicer_dimer	825..916	CDD:460900	27/97 (28%)
		PAZ_dicer_like	1091..1212	CDD:239209	33/129 (26%)
		RIBOc	1724..1930	CDD:238333	68/224 (30%)
		RIBOc	2008..2172	CDD:238333	78/201 (39%)
		DSRM_DICER	2177..2240	CDD:380680	22/65 (34%)