Protein Alignment Dcr-2 and Drosha

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_001101125.2
• Gene: Drosha / 310159
• RGDID: 1307626
• Length: 1373
• Species: Rattus norvegicus
• Alignment Length: 1332
• Identity: 239/1332 - (17%)
• Similarity: 394/1332 - (29%)
• Gaps: 580/1332 - (43%)

  Fly   599 EDERDRIFGVSAKGKH----VISINMP--------------------VNCMLRDTIY-SDPMDNV 638
            |:|:||.....:.||.    .|....|                    :.|...::.| |||||.|
  Rat   365 EEEKDRWSDSQSSGKEKSYTSIKEKEPEEAPPEKTEEEDEELLKPVWIRCTHSESYYSSDPMDQV 429

  Fly   639 KTAKISAAFKACKVLY-----SLGELNERF--------VPKTLKERVASIADVHFEHWNKYGDSV 690
            ..:.:....: .:.||     .||...|:.        .|||..:.                |..
  Rat   430 GDSTVVGTSR-LRDLYDKFEEELGNRQEKAKAARPPWEPPKTKLDE----------------DLE 477

  Fly   691 TATVNKADKSKDRTYKTECPLEFYDALPRV------------------------GEIC------- 724
            :::.::.:..:|.|..:....|.:|.:..:                        |.:|
  Rat   478 SSSESECETDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKAR 542

  Fly   725 ----------------------------YAYEI-------FLEPQFESCEYTEHMYLNLQTPRNY 754
                                        :.|.|       ||..:....||.:|.|:
  Rat   543 RTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYI-------- 599

  Fly   755 AILLRNKLPRLAEMPLFSNQGKLHVRVANAPL----------------EVIIQN--SEQLELLHQ 801
                      .....:|:     |..:.|.||                |::.:|  .:.|||...
  Rat   600 ----------FEGFSMFA-----HAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSL 649

  Fly   802 FHGMVFRDILKI--WH---PFFVLDRRSKENSYLVVPLILGAGEQKCFDWELMTNFRRLPQSHGS 861
            |   :|||||::  |:   |.|       |:|           ...|..:..|..|.|.....|.
  Rat   650 F---LFRDILELYDWNLKGPLF-------EDS-----------PPCCPRFHFMPRFVRFLPDGGK 693

  Fly   862 NVQQREQ--------QPAPRPEDFEGKIVTQW-------YANYDKPMLVTK-------------- 897
            .|....|        ..|..||: |...:.||       ||...|.|:||.
  Rat   694 EVLSMHQILLYLLRCSKALVPEE-EIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLD 757

  Fly   898 --------------VHRELTP--LSYMEKNQQDKTYYEFTMSKY--GNRIGDVVHKDKFMIEVRD 944
                          ||..:.|  |||....|..|.:..:...::  .|. ..|...||..:..|:
  Rat   758 REQFNPEVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANS-PKVKQTDKQKLAQRE 821

  Fly   945 LTEQLTFYVHNRGKFNAKSKAKMKVILIPELCFNFNFPG--------DLWLKLIFLPSILNRMYF 1001
                           .|..|.:.|..:..|:....:..|        |:....:.||.:.:.:.:
  Rat   822 ---------------EALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRY 871

  Fly  1002 ---LLHAEALRKRFNTYLNLHLLPFNGTDYMPRPLEIDYSLKRNVDPLGNVIPTEDIEEPKSLLE 1063
               |:|.:.|                          |.|:.                 :.:.||:
  Rat   872 HQCLMHLDKL--------------------------IGYTF-----------------QDRCLLQ 893

  Fly  1064 PMPTKSIEASVANLEITEFENPWQKYMEPVDLSRNLLSTYPVELDYYYHFSVGNVCEMNEMDFED 1128
                         |.:|...:.....|.| |.:||.||.                |.:.:..:.|
  Rat   894 -------------LAMTHPSHHLNFGMNP-DHARNSLSN----------------CGIRQPKYGD 928

  Fly  1129 KEYWAKNQFHMPTGNIYGNRTPAKTNANVPALMPSKPTVRGK-VKPLLILQKTVSKEHITPAEQG 1192
            ::.   :..||                            |.| :..|:.:...:.::..||:.
  Rat   929 RKV---HHMHM----------------------------RKKGINTLINIMSRLGQDDPTPSR-- 960

  Fly  1193 EFLAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEGTLTEVKSKLVSNRNLLFCL 1257
                         :...||||.|||:.::...:::|...:....||.|...::.:|.|::|
  Rat   961 -------------INHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHL---- 1008

  Fly  1258 IDADIPKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAKIIGPHNLRDLALGDEESLVKGN 1322
              |.:.|.|...:|                  .|:...|:..:   ..:||.......|:|:..
  Rat  1009 --AMLAKKLELDRF------------------MLYAHGPDLCR---ESDLRHAMANCFEALIGA- 1049

  Fly  1323 CSDINYNRFVEGCRANGQSFYAGADFSSEVNFCVGLVTIPNKVIADTLEALLGVIVKNYGLQHAF 1387
                   .::||.....:..:....|:.                .|..|..|     ||.| |..
  Rat  1050 -------VYLEGTLEEAKQLFGRLLFND----------------PDLREVWL-----NYPL-HPL 1085

  Fly  1388 KMLEYFKICRADIDKPLT--QLLNLELGGKKMRANVNTTEIDGFLINHYYLEKNLGYTFKDRRYL 1450
            ::.|           |.|  ||:......:|:      ||          .|:.:|..|...|.|
  Rat  1086 QLQE-----------PNTDRQLIETSPVLQKL------TE----------FEEAIGVIFTHVRLL 1123

  Fly  1451 LQALTHPSYPTNRIT-GSYQELEFIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLAC 1514
            .:|.|..:...|.:| |..|.:||:||:|:..:.:.|:|.:....:.|.||.|||:||||.|
  Rat  1124 ARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRT--- 1185

  Fly  1515 ICVRHRLHFFILAENAKLSEIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTEL 1579
                          .||::|.:.       .|.:.:||                      |.|:.
  Rat  1186 --------------QAKVAEELG-------MQEYAITN----------------------DKTKR 1207

  Fly  1580 PHANKCISQEAEKGVPPKGEFNMSTNVDVPKALGDVLEALIAAVYLDCRDLQRTWEVIFNLFEPE 1644
            |.|.:                        .|.|.|:||:.|||:|:| :||:.....:...|.|.
  Rat  1208 PVALR------------------------TKTLADLLESFIAALYID-KDLEYVHTFMNVCFFPR 1247

  Fly  1645 LQEFTRK-------------------------VPINHIRQLVEHKHAKPVFSSPIVEGETVMVSC 1684
            |:||...                         :|:....|.|...||:....:...:||  .:.|
  Rat  1248 LKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGE--RIGC 1310

  Fly  1685 QFTCMEKTIKVYGFGSNKDQAKLSAAKHALQQ 1716
                        |.|.:..||::.||..||::
  Rat  1311 ------------GKGPSIQQAEMGAAMDALEK 1330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792
		Dicer_PBD	241..343	CDD:277191
		SF2_C_dicer	360..506	CDD:350189
		Dicer_dimer	571..670	CDD:460900	24/108 (22%)
		PAZ	843..1004	CDD:198017	41/218 (19%)
		RIBOc	1194..1391	CDD:238333	34/196 (17%)
		RIBOc	1448..1649	CDD:238333	52/201 (26%)
		dsrm	1653..1717	CDD:425434	16/64 (25%)
Drosha	NP_001101125.2	SF-CC1	212..>274	CDD:273721
		RIBOc	958..1078	CDD:238333	30/185 (16%)
		Rnc	1104..1332	CDD:440336	75/328 (23%)