Protein Alignment Dcr-2 and Dhx58

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_001092258.1
• Gene: Dhx58 / 303538
• RGDID: 1310093
• Length: 678
• Species: Rattus norvegicus
• Alignment Length: 593
• Identity: 140/593 - (23%)
• Similarity: 252/593 - (42%)
• Gaps: 112/593 - (18%)

  Fly     4 VEIKPRGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVE 68
            :|::|..::: ::..|...|.|::||||:|||..|..|.||..:..|:     || .:.:.|.|.
  Rat     1 MELRPYQWEV-ILPALEGKNIIIWLPTGAGKTRAAAFVAKRHLETVDR-----GK-VVVLVNRVH 58

  Fly    69 LARQQAMAVRRCTN--FKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVTQT----- 126
            |..|.|...||..:  :.|....|:.|    :|..:....:.:.:|:.||:: |.:..::
  Rat    59 LVNQHAEEFRRMLDKQWTVTTLSGDMG----SRAGFGLLARSHDLLICTAEL-LHLALKSSEEDE 118

  Fly   127 YVALSSLSVVIIDECHHGTGHHPFREFMRLF---TIANQTKLPRVVGLTGVLIKGNEITNVATKL 188
            :|.|:..|::::|||||......:...:..:   .:.....||:|:|||     .:..|..||||
  Rat   119 HVELTEFSLIVVDECHHTHKDTIYNTILSRYLEHKLKKAKPLPQVLGLT-----ASPGTGGATKL 178

  Fly   189 KE-----LEITYRGNIITVSDTKEMENVML-YATKP------TEVMVSFPHQEQVLTVTRLISAE 241
            :.     |::....:...:...|...:.:| :..||      .:.....|..:.:..:.:.|..:
  Rat   179 QGAIDHILQLCANLDTWRIMSPKNCYSQLLEHNPKPCKQYDLCQRRTQDPFGDLLKKLMKQIHQQ 243

  Fly   242 IEKFYVSLDL-MNIGVQPIRRSKSLQCLRDPSKKSFVKQ--------LFNDFLYQMKEYGIYAAS 297
            :|    ..|| ...|.| :...:.:|..:|.::....:|        .:||.||.......:.|
  Rat   244 LE----MPDLKQQFGTQ-MYEQQVVQLSKDAAEAGLQEQRVYALHLRRYNDALYIHDTVRAWDA- 302

  Fly   298 IAIISLIVEF-DIKRRQAETLSVKLMH--RTALTLCEKIRHLLVQKLQDMTYDDDDDNVNTEEVI 359
               ::::.:| |.:|    .|..:::|  |..|.|.:..|..|.|
  Rat   303 ---LNMLQDFYDTER----ALKTQMVHAERWLLELFDDHRKALAQ-------------------- 340

  Fly   360 MNFS-----TPKVQRFLMSLKVSFADKDPKDICCLVFVERRYTCKCIYGLLLNYIQSTPELRNV- 418
              |:     .||::.....|...|.  .|.....::|...|.|...    ||.:::..|.|:.|
  Rat   341 --FAAQGPENPKLEMLEGILLKQFG--SPDHTRGIIFTRTRQTASS----LLLWLRQQPCLQTVN 397

  Fly   419 LTPQFMVGRNNISPDFESVLERKWQKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFILDPVK 483
            :.||.::|..|...  .:.:.:|.|:..||:||||..||::.:||.|||:|:..||.|.....:.
  Rat   398 IKPQMLIGAGNTGQ--STHMTQKDQQEVIQEFRDGKLNLLVATSVAEEGLDIAQCNVVVRYGLLT 460

  Fly   484 TFNMYVQSKGRARTTEAKFVLFTADKEREKTIQQIYQYRKAHNDIAEYLKDR---VLEKTEPELY 545
            .....||::||||..::.:.....:..||..       |:..|:..|.|.::   .::|.:||
  Rat   461 NEISMVQARGRARAGQSVYSFVATEGSREIK-------RELTNEALEVLMEQAVAAVQKMDPE-- 516

  Fly   546 EIKGHFQD 553
            |.|...||
  Rat   517 EFKAKIQD 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792	53/212 (25%)
		Dicer_PBD	241..343	CDD:277191	24/113 (21%)
		SF2_C_dicer	360..506	CDD:350189	43/151 (28%)
		Dicer_dimer	571..670	CDD:460900
		PAZ	843..1004	CDD:198017
		RIBOc	1194..1391	CDD:238333
		RIBOc	1448..1649	CDD:238333
		dsrm	1653..1717	CDD:425434
Dhx58	NP_001092258.1	MPH1	1..>523	CDD:440728	138/590 (23%)
		DEAD-like_helicase_N	1..200	CDD:475120	54/215 (25%)
		LGP2_C	552..664	CDD:276944