DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-2 and Dicer1

DIOPT Version :9

Sequence 1:NP_523778.2 Gene:Dcr-2 / 36993 FlyBaseID:FBgn0034246 Length:1722 Species:Drosophila melanogaster
Sequence 2:XP_008763126.1 Gene:Dicer1 / 299284 RGDID:1309381 Length:1918 Species:Rattus norvegicus


Alignment Length:2001 Identity:514/2001 - (25%)
Similarity:853/2001 - (42%) Gaps:427/2001 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PRGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVELARQ 72
            ||.||:.|::.....|.||.|.|||||||:|:|:.|..:......:....||.:|:.|:.....|
  Rat    44 PRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLSPHAKRTVFLVNSANQVAQ 108

  Fly    73 QAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVTQTYVALSSLSVVI 137
            |..|||..::.|||.|...:....||:..||.|..|:|||:.|..|.|:::...|::||.:::::
  Rat   109 QVSAVRTHSDLKVGEYSNLEVNASWTKERWSQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLV 173

  Fly   138 IDECHHGTGHHPFREFMRLFTIANQTKLPRVVGLTGVLIKGN-EITNVATKLKELEITYRGNIIT 201
            .||||.....||:||.|:|  ..:....||::|||..::.|. :...:..|:::||...:....|
  Rat   174 FDECHLAILDHPYREIMKL--CDSCPSCPRILGLTASILNGKCDPDELEEKIQKLEKILKSGAET 236

  Fly   202 VSDTKEMENVMLYATKPTEVMVSF-PHQEQVLTVTRLISAEIEKFYVSLDLMNIGVQPIRRSKSL 265
            .:|...::.   |.::|.|::|.. |..::.....||: .|:|:....::..|:.|....|..:|
  Rat   237 ATDLVVLDR---YTSQPCEIVVDCGPFTDRSGLYERLL-MELEEALDFINDCNVSVHSKERDSTL 297

  Fly   266 QCLRDPSKKSFVKQLFNDFLYQMKEYGIYAASIAIISLIVEFD--IKRRQAETLSVKLMHRTAL- 327
                      ..||:.:|....:...|.:.|......::.|..  ||..|.|      :||..| 
  Rat   298 ----------ISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEE------LHRKFLL 346

  Fly   328 ---TLCEKIRHLLVQKLQDMTYDDDDDNVNTEEVIMNFSTPKVQRFLMSLK-------------- 375
               ||..||..|..:.....:.|            :.:.||||.:.|..|:              
  Rat   347 FTDTLLRKIHALCEEYFSPASLD------------LKYVTPKVMKLLEILRKYKPYERQQFESVE 399

  Fly   376 ----------VSFADKDPKD----------------------ICCLVFVERRYTCKCIYGLLLNY 408
                      ||::|.:..|                      :|.::|||||||...:..|:...
  Rat   400 WYNNRNQDNYVSWSDSEDDDDDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEA 464

  Fly   409 IQSTPELRNVLTPQFM----VGRNN-ISPDFESVLERKWQKSAIQQFRDGNANLMICSSVLEEGI 468
            .:..|||. .::..|:    :|:|. .|...|:  |.:.|:..:::||....||:|.:||:|||:
  Rat   465 GKQDPELA-YISSNFITGHGIGKNQPRSKQMEA--EFRKQEEVLRKFRAHETNLLIATSVVEEGV 526

  Fly   469 DVQACNHVFILDPVKTFNMYVQSKGRARTTEAKFVLFTADKEREKTIQQIYQYRKAHNDIAEYLK 533
            |:..||.|...|....:..|||||||||...:.:|:. ||.::.|:.::..:..||...|.....
  Rat   527 DIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVML-ADTDKIKSFEEDLKTYKAIEKILRNKC 590

  Fly   534 DRVLEKTEPELYEIKGHFQDDIDPF------TNENGAVLLPNNALAILHRYCQTIPTDAFGFVIP 592
            .:.::..|.:::.:    .||.|.|      .::.|..:..|.|:..::|||..:|:|.|..:.|
  Rat   591 SKSVDGAEADVHAV----VDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAP 651

  Fly   593 WFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRDTIYSDPMDNVKTAKISAAFKACKVLYSLG 657
            .....:..:          |....::.:|:|..||.:|...||..|:.|:...|...|:.|:.:|
  Rat   652 KCRTRELPD----------GTFYSTLYLPINSPLRASIVGPPMGCVRLAERVVALICCEKLHKIG 706

  Fly   658 ELNERFVP---KTLKERVASIADVHFEHWNKYGDSVTATVNKADKSKDR-TYKTECPLEFYDALP 718
            ||:|..:|   :|:|         :.|..:.:.:..|:...:...:|.| .|....|....::.|
  Rat   707 ELDEHLMPVGKETVK---------YEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRESYP 762

  Fly   719 RVGEICYAYEI---FLEPQFESCEYTEH-MYLNLQTPRNYAILLRNKLPRLAEMPLFSNQGKLHV 779
            :..:.||.|.|   ...|..:...:... :|....|.|.:.||....:|::...|:::..|::.:
  Rat   763 KPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTI 827

  Fly   780 RVANAPLEVIIQNSEQLELLHQFHGMVFRDILKIWHPFFVLDRRSKENSYLVVPL-ILGAGEQKC 843
            .: .........:.:.|||:.:.|..:|..||::..|.........|::|.|:|| ::.......
  Rat   828 SI-ELKKSGFTLSQQMLELVTRLHQYIFSHILRLEKPALEFQPAGAESAYCVLPLNVVNDSSTLD 891

  Fly   844 FDWELMTNFRRLPQSHG--SNVQQREQQPAPRPEDFEGKIVTQWYANYDKP--MLVTKVHRELTP 904
            .|::.|.:..:.....|  |....:|.....:.||::..::...|.|:|:|  ..|..|:.:|||
  Rat   892 IDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTP 956

  Fly   905 LSYMEKNQQDKTYYEFTMSKYGNRIGDVVHKDKFMIEVRDLTEQLTF----YVHNRGK-----FN 960
            ||.....:.: |:.|:..:||..   |:.:.::.:::|...:.:|..    :::.:||     ..
  Rat   957 LSKFPSPEYE-TFAEYYKTKYNL---DLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSA 1017

  Fly   961 AKSKAKM-----KVILIPELCFNFNFPGDLWLKLIFLPSILNRMYFLLHAEALRKR--FNTYLNL 1018
            .|.|||.     |.||:||||.....|..||.|.:.|||||.|::.||.||.||.:  .:..:.:
  Rat  1018 EKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGV 1082

  Fly  1019 HLLPFNGTDYMPRPLEIDYSLKRNVDPLGNVIPTEDIEEPKSLLE-----PMPTKSIEASVANLE 1078
            ..||   .|:  |...:|:..|:::|....:....     .||.|     ...|..:..:.|:..
  Rat  1083 RSLP---ADF--RYPNLDFGWKKSIDSKSFISTCN-----SSLAESDNYCKHSTTVVPENAAHQG 1137

  Fly  1079 IT--EFENPWQKYME----PVDLSRNLLSTYPVEL----DYYYHFSVGN---------VCEMNEM 1124
            .|  ..||..|..:.    |.:....|.|...|:|    ...|:.|:.|         .|:.|::
  Rat  1138 ATRPSLENHDQMSVNCKRLPAESPAKLQSEVSVDLTAINGLSYNKSLANGSYDLVNRDFCQGNQL 1202

  Fly  1125 DFEDKEYWAKNQFHMPTGNIY--------GNRTPAKT------NANV------------PALMPS 1163
            .:..:|...:.....|..|:|        .|..|..:      |||.            ||:|.:
  Rat  1203 TYFKQEIPVQPTTSYPIQNLYNYENQPTPSNECPLLSNKYLDGNANTSTSDGSPAGSPRPAMMTA 1267

  Fly  1164 KPTVRGKVKPLLILQKTVSKEHITPA---EQGEFLAAITASSAADVFDMERLEILGDSFLKLSAT 1225
            ...:.|:...    :::.|..|.:..   ..|..|.|:|.|:|:|.|::||||:|||||||.:.|
  Rat  1268 VEALEGRTDS----EQSPSVGHSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAIT 1328

  Fly  1226 LYLASKYSDWNEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPPGISLPHN--- 1287
            .||...|.|.:||.|:.::||.|||.||........:|..:....|.|...|||||..:..:   
  Rat  1329 TYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKQGLPSRMVVSIFDPPVNWLPPGYVVNQDKSN 1393

  Fly  1288 -------------VLA----------------LWRENPEFAKI---------------------- 1301
                         :||                .||...|.|:.                      
  Rat  1394 SEKWEKDEMTKDCLLANGKLGEDCEEEEEEELAWRAPKEEAEYEDDLLEYDQEHIQFIDSMLMGS 1458

  Fly  1302 --------IGPHNLRDLA----LGDEESL----VKGNCSDINYNRFVEGCRANGQSFYAGADF-- 1348
                    :.|.:..|.|    :..:.||    ...:..|.:|:.:...|..:........||  
  Rat  1459 GAFVKKIPLSPFSTSDSAYEWKMPKKASLGSVPFSSDLEDFDYSSWDAMCYLDPSKAVEEDDFVV 1523

  Fly  1349 ----SSEVNFCVGLVT--------------IPNKVIADTLEALLGVIVKNYGLQHA--------F 1387
                .||.| | |:.|              |.:|.|||.:|||||..:.:.|.:.|        .
  Rat  1524 GFWNPSEEN-C-GVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGL 1586

  Fly  1388 KMLEYFK------------------------ICRADIDKPLTQLLNLELGGKKM--RANVNTTEI 1426
            |:|...|                        .|.|.:....:...:||.|..|:  |...:..:.
  Rat  1587 KVLPVIKRTSRDKASYPAQENSSSQQKSPSGSCAAAVSPRSSAGKDLEYGCLKIPPRCMFDHPDA 1651

  Fly  1427 DGFLINHYY-----LEKNLGYTFKDRRYLLQALTHPSYPTNRITGSYQELEFIGDAILDFLISAY 1486
            :..| ||..     .||.:.|.||::.|||||.||.||..|.||..||.|||:||||||:||:.:
  Rat  1652 EKTL-NHLISGFENFEKKINYIFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKH 1715

  Fly  1487 IFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVNFQESQGHRVT 1551
            ::|:..:.:||.||||||||||||..|.:.|::..|.:..|.:.:|..:|..||.||        
  Rat  1716 LYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQ-------- 1772

  Fly  1552 NYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNVDVPKALGDVL 1616
                  ||:.::|    .:|.||..:|         ::.||          ..:::||||:||:.
  Rat  1773 ------LEKNEMQ----GMDSELRRSE---------EDEEK----------EEDIEVPKAMGDIF 1808

  Fly  1617 EALIAAVYLDC-RDLQRTWEVIFNLFEPELQEFTRKVPINHIRQLVEHKHAKPVFSSPIVEGETV 1680
            |:|..|:|:|. ..|:..|:|.:.:..|.:::|:..||.:.:|:|:|            :|.|| 
  Rat  1809 ESLAGAIYMDSGMSLEVVWQVYYPMMRPLIEKFSANVPRSPVRELLE------------MEPET- 1860

  Fly  1681 MVSCQFTCMEK--------TIKVYGFGSNKDQ------AKLSAAKHALQQL 1717
               .:|:..|:        |::|.|.|..|..      ||.:||:.||:.|
  Rat  1861 ---AKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSL 1908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-2NP_523778.2 MPH1 6..542 CDD:224036 160/592 (27%)
DEXDc 22..173 CDD:238005 56/150 (37%)
Dicer_PBD 241..343 CDD:277191 24/107 (22%)
HELICc <438..495 CDD:197757 23/56 (41%)
Dicer_dimer 572..665 CDD:281376 24/92 (26%)
PAZ 843..1004 CDD:198017 49/178 (28%)
RIBOc 1194..1391 CDD:238333 76/294 (26%)
Rnc 1433..1719 CDD:223644 103/305 (34%)
RIBOc 1448..1649 CDD:238333 74/201 (37%)
dsrm 1653..1717 CDD:278464 20/77 (26%)
Dicer1XP_008763126.1 DEXHc_dicer 42..239 CDD:350792 67/196 (34%)
Dicer_PBD 271..365 CDD:277191 24/110 (22%)
SF2_C_dicer 372..564 CDD:350189 54/195 (28%)
Dicer_dimer 630..718 CDD:397444 26/97 (27%)
PAZ_dicer_like 886..1008 CDD:239209 25/125 (20%)
RIBOc 1296..>1387 CDD:197778 41/90 (46%)
RIBOc 1678..1842 CDD:238333 74/200 (37%)
DSRM_DICER 1847..1909 CDD:380680 20/78 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 103 1.000 Domainoid score I6656
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57860
OrthoDB 1 1.010 - - D126291at33208
OrthoFinder 1 1.000 - - FOG0002051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101152
Panther 1 1.100 - - O PTHR14950
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1728
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.830

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