Protein Alignment Dcr-2 and Rig1

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_001382000.1
• Gene: Rig1 / 297989
• RGDID: 1309460
• Length: 926
• Species: Rattus norvegicus
• Alignment Length: 810
• Identity: 168/810 - (20%)
• Similarity: 307/810 - (37%)
• Gaps: 234/810 - (28%)

  Fly     6 IKPRGYQLRLVDHLTK-SNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVEL 69
            :|||.|||.|.....| .|.::..|||.|||||::|:.:...::|  |....|| .:|..|.:.:
  Rat   242 LKPRNYQLELALPAKKGKNTVICAPTGCGKTFVSLLICEHHLKNF--PHGQKGK-VVFFANQIPV 303

  Fly    70 ARQQAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDE--IKKNQVLVGTAQVFLDMVTQTYV-ALS 131
            ..|||....|... :.|:.|.  |:...|....|.:  |:.|.:::.|.|:.::.:....: :||
  Rat   304 YEQQATVFSRYFE-RFGYNVA--GISGATADNVSVQHIIENNDIVILTPQILVNSLNNGAIPSLS 365

  Fly   132 SLSVVIIDECHHGTGHHPFREFMRLFTI----ANQTKLPRVVGLTGVLIKGNEITNVATKLKELE 192
            ..:::|.||||:.:.|||:.:.|..:..    .:...||:|:|||.
  Rat   366 VFTLMIFDECHNTSKHHPYNQIMFRYLDHKLGGSPDPLPQVIGLTA------------------- 411

  Fly   193 ITYRGNIITVSDTKEMENVMLY---------ATKPTEVMVSFPHQEQVLTVTRLISAEIEKFYVS 248
                  .:.|.|.|.:|..||:         |:....|..:....|||:...:.||.::|.
  Rat   412 ------SVGVGDAKTVEEAMLHICKLCAALDASVIATVRDNVEELEQVVYKPQKISRKVES---- 466

  Fly   249 LDLMNIGVQPIRRSKSLQC-----LRDPSK--KSFVKQLFNDFLYQMKEYGIYAAS---IAIISL 303
                       |.|.:.:|     :|:..:  |:..::|...|..|.:|:|.....   :|:...
  Rat   467 -----------RASNTFKCIISQLMREAERLAKNVSEELGKFFQIQNREFGTQKYEQWIVAVHKA 520

  Fly   304 IVEFDIKRRQAETLSVKLM---------HRTALTLCE------KIRHL--LVQKLQDMTYDDDDD 351
            ...|.:..:..|:...|.:         :..||.:.|      .:.:|  ....:::..:|:.:.
  Rat   521 CTVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEDAQMKDALNYLKAFFHDVREAAFDETEQ 585

  Fly   352 NVNTE-----EVIMNFS------TPKVQRFLMSLKVSFADK-DPKDICCLVFVERRYTCKCIYGL 404
            ::...     |.:.|.|      .||::...:.|:..:..| :.|.|   :||:.|    .:...
  Rat   586 DLTRRFEEKLEELENVSRDPSNENPKLRDLYLILQEEYHLKPETKTI---LFVKTR----ALVDA 643

  Fly   405 LLNYIQSTPELRNVLTPQFMVGRNNISPDFESVLERKWQKSAIQQFR-DGNANLMICSSVLEEGI 468
            |..:|:..|.| :.|.|..:.||...:......|..  ||..::.|| :.:.|::|.:||.:|||
  Rat   644 LKKWIEENPAL-SFLKPGILTGRGRTNQATGMTLPA--QKCVLEAFRANADNNILIATSVADEGI 705

  Fly   469 DVQACNHVFILDPVKTFNMYVQSKGRARTTEAKFVLFTADK---EREKTIQQIYQYRKAHNDIAE 530
            |:..||.|.:.:.|......:|::||.|..::|..|.|:..   |:||               |.
  Rat   706 DIAQCNLVILYEYVGNVIKMIQTRGRGRARDSKCFLLTSSADVIEKEK---------------AN 755

  Fly   531 YLKDRVLEKTEPELY---EIKGHFQDDIDPFTNENGAVLLPNNALAILHRYCQTIPTDAFGFVIP 592
            .:|::::.::...|.   |:|  ||..:
  Rat   756 MVKEKIMNESILRLQTWDEVK--FQKTV------------------------------------- 781

  Fly   593 WFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRDTIYS-DPMDNVKTAKISAAFKACKVLYSL 656
              |.:|.||:                      :|||:.:. .|:.:.:..|:...  .|
  Rat   782 --HRIQLDEK----------------------LLRDSQHKPQPVPDRENKKLLCG--KC------ 814

  Fly   657 GELNERFVPKTLKERVASIADVHFEHWNKYGDSVTATVNKADKSKDR-TYKTECPLEFYDALPRV 720
                     ||.....|.|..|...|:...||:.          |:| ..|.....:.||:..:.
  Rat   815 ---------KTFACYTADIRVVEKSHYTVLGDAF----------KERFVCKPHPKPKIYDSFEKK 860

  Fly   721 GEICYAYEIFLEPQFESCEYTEHMYLNLQT 750
            .:|..|.        ::|.:...:::..:|
  Rat   861 AKIFCAK--------QNCSHDWGIFVRYKT 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792	55/205 (27%)
		Dicer_PBD	241..343	CDD:277191	19/128 (15%)
		SF2_C_dicer	360..506	CDD:350189	42/153 (27%)
		Dicer_dimer	571..670	CDD:460900	12/99 (12%)
		PAZ	843..1004	CDD:198017
		RIBOc	1194..1391	CDD:238333
		RIBOc	1448..1649	CDD:238333
		dsrm	1653..1717	CDD:425434
Rig1	NP_001382000.1	CARD_RIG-I_r1	2..92	CDD:260075
		CARD_RIG-I_r2	100..186	CDD:260076
		MPH1	242..>788	CDD:440728	143/657 (22%)
		DEXHc_RIG-I_DDX58	242..443	CDD:350831	61/231 (26%)
		RIG-I_C	806..919	CDD:276943	19/112 (17%)