DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-2 and Ddx58

DIOPT Version :9

Sequence 1:NP_523778.2 Gene:Dcr-2 / 36993 FlyBaseID:FBgn0034246 Length:1722 Species:Drosophila melanogaster
Sequence 2:NP_001382000.1 Gene:Ddx58 / 297989 RGDID:1309460 Length:926 Species:Rattus norvegicus


Alignment Length:810 Identity:168/810 - (20%)
Similarity:307/810 - (37%) Gaps:234/810 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IKPRGYQLRLVDHLTK-SNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVEL 69
            :|||.|||.|.....| .|.::..|||.|||||::|:.:...::|  |....|| .:|..|.:.:
  Rat   242 LKPRNYQLELALPAKKGKNTVICAPTGCGKTFVSLLICEHHLKNF--PHGQKGK-VVFFANQIPV 303

  Fly    70 ARQQAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDE--IKKNQVLVGTAQVFLDMVTQTYV-ALS 131
            ..|||....|... :.|:.|.  |:...|....|.:  |:.|.:::.|.|:.::.:....: :||
  Rat   304 YEQQATVFSRYFE-RFGYNVA--GISGATADNVSVQHIIENNDIVILTPQILVNSLNNGAIPSLS 365

  Fly   132 SLSVVIIDECHHGTGHHPFREFMRLFTI----ANQTKLPRVVGLTGVLIKGNEITNVATKLKELE 192
            ..:::|.||||:.:.|||:.:.|..:..    .:...||:|:|||.                   
  Rat   366 VFTLMIFDECHNTSKHHPYNQIMFRYLDHKLGGSPDPLPQVIGLTA------------------- 411

  Fly   193 ITYRGNIITVSDTKEMENVMLY---------ATKPTEVMVSFPHQEQVLTVTRLISAEIEKFYVS 248
                  .:.|.|.|.:|..||:         |:....|..:....|||:...:.||.::|.    
  Rat   412 ------SVGVGDAKTVEEAMLHICKLCAALDASVIATVRDNVEELEQVVYKPQKISRKVES---- 466

  Fly   249 LDLMNIGVQPIRRSKSLQC-----LRDPSK--KSFVKQLFNDFLYQMKEYGIYAAS---IAIISL 303
                       |.|.:.:|     :|:..:  |:..::|...|..|.:|:|.....   :|:...
  Rat   467 -----------RASNTFKCIISQLMREAERLAKNVSEELGKFFQIQNREFGTQKYEQWIVAVHKA 520

  Fly   304 IVEFDIKRRQAETLSVKLM---------HRTALTLCE------KIRHL--LVQKLQDMTYDDDDD 351
            ...|.:..:..|:...|.:         :..||.:.|      .:.:|  ....:::..:|:.:.
  Rat   521 CTVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEDAQMKDALNYLKAFFHDVREAAFDETEQ 585

  Fly   352 NVNTE-----EVIMNFS------TPKVQRFLMSLKVSFADK-DPKDICCLVFVERRYTCKCIYGL 404
            ::...     |.:.|.|      .||::...:.|:..:..| :.|.|   :||:.|    .:...
  Rat   586 DLTRRFEEKLEELENVSRDPSNENPKLRDLYLILQEEYHLKPETKTI---LFVKTR----ALVDA 643

  Fly   405 LLNYIQSTPELRNVLTPQFMVGRNNISPDFESVLERKWQKSAIQQFR-DGNANLMICSSVLEEGI 468
            |..:|:..|.| :.|.|..:.||...:......|..  ||..::.|| :.:.|::|.:||.:|||
  Rat   644 LKKWIEENPAL-SFLKPGILTGRGRTNQATGMTLPA--QKCVLEAFRANADNNILIATSVADEGI 705

  Fly   469 DVQACNHVFILDPVKTFNMYVQSKGRARTTEAKFVLFTADK---EREKTIQQIYQYRKAHNDIAE 530
            |:..||.|.:.:.|......:|::||.|..::|..|.|:..   |:||               |.
  Rat   706 DIAQCNLVILYEYVGNVIKMIQTRGRGRARDSKCFLLTSSADVIEKEK---------------AN 755

  Fly   531 YLKDRVLEKTEPELY---EIKGHFQDDIDPFTNENGAVLLPNNALAILHRYCQTIPTDAFGFVIP 592
            .:|::::.::...|.   |:|  ||..:                                     
  Rat   756 MVKEKIMNESILRLQTWDEVK--FQKTV------------------------------------- 781

  Fly   593 WFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRDTIYS-DPMDNVKTAKISAAFKACKVLYSL 656
              |.:|.||:                      :|||:.:. .|:.:.:..|:...  .|      
  Rat   782 --HRIQLDEK----------------------LLRDSQHKPQPVPDRENKKLLCG--KC------ 814

  Fly   657 GELNERFVPKTLKERVASIADVHFEHWNKYGDSVTATVNKADKSKDR-TYKTECPLEFYDALPRV 720
                     ||.....|.|..|...|:...||:.          |:| ..|.....:.||:..:.
  Rat   815 ---------KTFACYTADIRVVEKSHYTVLGDAF----------KERFVCKPHPKPKIYDSFEKK 860

  Fly   721 GEICYAYEIFLEPQFESCEYTEHMYLNLQT 750
            .:|..|.        ::|.:...:::..:|
  Rat   861 AKIFCAK--------QNCSHDWGIFVRYKT 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-2NP_523778.2 MPH1 6..542 CDD:224036 136/595 (23%)
DEXDc 22..173 CDD:238005 45/157 (29%)
Dicer_PBD 241..343 CDD:277191 19/128 (15%)
HELICc <438..495 CDD:197757 19/57 (33%)
Dicer_dimer 572..665 CDD:281376 10/93 (11%)
PAZ 843..1004 CDD:198017
RIBOc 1194..1391 CDD:238333
Rnc 1433..1719 CDD:223644
RIBOc 1448..1649 CDD:238333
dsrm 1653..1717 CDD:278464
Ddx58NP_001382000.1 CARD_RIG-I_r1 2..92 CDD:260075
CARD_RIG-I_r2 100..186 CDD:260076
MPH1 242..784 CDD:224036 142/653 (22%)
DEXHc_RIG-I_DDX58 242..443 CDD:350831 61/231 (26%)
RIG-I_C 806..919 CDD:276943 19/112 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1337630at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

Return to query results.
Submit another query.