Protein Alignment Dcr-2 and DROSHA

DIOPT Version :9

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_001369437.1
• Gene: DROSHA / 29102
• HGNCID: 17904
• Length: 1374
• Species: Homo sapiens
• Alignment Length: 1467
• Identity: 258/1467 - (17%)
• Similarity: 437/1467 - (29%)
• Gaps: 625/1467 - (42%)

  Fly   490 QSKGRARTTEAKFVLFTADKEREKTIQQIYQYRKAHNDIAEYLKDR------VLEKTEPELYEIK 548
            :.:||:.....:...:.:|.:|.:|..:...|.::.....|..:.|      .||::..:.|:..
Human   250 RERGRSPDRRRQDSRYRSDYDRGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRS 314

  Fly   549 GHFQDDIDPFTNENGAVLLPNNALAILHRYC-QTIPTDAFGFVIPWFHVLQ-------------- 598
            |          ...|..::|..|      .| ..:|.:.......|...|:
Human   315 G----------RSYGLSVVPEPA------GCTPELPGEIIKNTDSWAPPLEIVNHRSPSREKKRA 363

  Fly   599 --EDERDRIFG--VSAKGKHVISI-------NMP---------------VNCMLRDTIY-SDPMD 636
              |:|:||...  .|.|.|:..||       .||               :.|...:..| |||||
Human   364 RWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMD 428

  Fly   637 NVKTAKISAAFKACKVLY-----SLGELNERF--------VPKTLKERVASIADVHFEHWNKYGD 688
            .|..:.:....: .:.||     .||...|:.        .|||..:.                |
Human   429 QVGDSTVVGTSR-LRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDE----------------D 476

  Fly   689 SVTATVNKADKSKDRTYKTECPLEFYDALPRV------------------------GEIC----- 724
            ..:::.::.:..:|.|..:....|.:|.:..:                        |.:|
Human   477 LESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAK 541

  Fly   725 ------------------------------YAYEI-------FLEPQFESCEYTEHMYLNLQTPR 752
                                          :.|.|       ||..:....||.:|.|:
Human   542 ARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYI------ 600

  Fly   753 NYAILLRNKLPRLAEMPLFSNQGKLHVRVANAPL----------------EVIIQN--SEQLELL 799
                        .....:|:     |..:.|.||                |::.:|  .:.|||.
Human   601 ------------FEGFSMFA-----HAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELF 648

  Fly   800 HQFHGMVFRDILKI--WH---PFFVLDRRSKENSYLVVPLILGAGEQKCFDWELMTNFRRLPQSH 859
            ..|   :|||||::  |:   |.|       |:|           ...|..:..|..|.|.....
Human   649 SLF---LFRDILELYDWNLKGPLF-------EDS-----------PPCCPRFHFMPRFVRFLPDG 692

  Fly   860 GSNVQQREQ--------QPAPRPEDFEGKIVTQW-------YANYDKPMLVTK------------ 897
            |..|....|        ..|..||: |...:.||       ||...|.|:||.
Human   693 GKEVLSMHQILLYLLRCSKALVPEE-EIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQ 756

  Fly   898 ----------------VHRELTP--LSYMEKNQQDKTYYEFTMSKY--GNRIGDVVHKDKFMIEV 942
                            ||..:.|  |||....|..|.:..:...::  .|. ..|...||..:..
Human   757 LDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANS-PKVKQTDKQKLAQ 820

  Fly   943 RDLTEQLTFYVHNRGKFNAKSKAKMKVILIPELCFNFNFPG--------DLWLKLIFLPSILNRM 999
            |:               .|..|.:.|..:..|:....:..|        |:....:.||.:.:.:
Human   821 RE---------------EALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHI 870

  Fly  1000 YF---LLHAEALRKRFNTYLNLHLLPFNGTDYMPRPLEIDYSLKRNVDPLGNVIPTEDIEEPKSL 1061
            .:   |:|.:.|                          |.|:.                 :.:.|
Human   871 RYHQCLMHLDKL--------------------------IGYTF-----------------QDRCL 892

  Fly  1062 LEPMPTKSIEASVANLEITEFENPWQKYMEPVDLSRNLLSTYPVELDYYYHFSVGNVCEMNEMDF 1126
            |:             |.:|...:.....|.| |.:||.||.                |.:.:..:
Human   893 LQ-------------LAMTHPSHHLNFGMNP-DHARNSLSN----------------CGIRQPKY 927

  Fly  1127 EDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPALMPSKPTVRGK-VKPLLILQKTVSKEHITPAE 1190
            .|::.   :..||                            |.| :..|:.:...:.::..||:.
Human   928 GDRKV---HHMHM----------------------------RKKGINTLINIMSRLGQDDPTPSR 961

  Fly  1191 QGEFLAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEGTLTEVKSKLVSNRNLLF 1255
                           :...||||.|||:.::...:::|...:....||.|...::.:|.|::|
Human   962 ---------------INHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHL-- 1009

  Fly  1256 CLIDADIPKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAKIIGPHNLRDLALGDEESLVK 1320
                |.:.|.|...:|                  .|:...|:..:.
Human  1010 ----AMLAKKLELDRF------------------MLYAHGPDLCRE------------------- 1033

  Fly  1321 GNCSDINYNRFVEGCRANGQSFYAGADFSSEVNFCVGLVTIPNKVIADTLEALLGVIVKNYGLQH 1385
               ||:.:                                    .:|:..|||:|.:.....|:.
Human  1034 ---SDLRH------------------------------------AMANCFEALIGAVYLEGSLEE 1059

  Fly  1386 AFKMLEYFKICRADIDKPLTQL-LNLELGGKKMRANVNT----TEIDGFLINHYYLEKNLGYTFK 1445
            |.::  :.::...|.|  |.:: ||..|...::: ..||    .|....|......|:.:|..|.
Human  1060 AKQL--FGRLLFNDPD--LREVWLNYPLHPLQLQ-EPNTDRQLIETSPVLQKLTEFEEAIGVIFT 1119

  Fly  1446 DRRYLLQALTHPSYPTNRIT-GSYQELEFIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNN 1509
            ..|.|.:|.|..:...|.:| |..|.:||:||:|:..:.:.|:|.:....:.|.||.|||:||||
Human  1120 HVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNN 1184

  Fly  1510 TTLACICVRHRLHFFILAENAKLSEIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLDDEL 1574
            .|                 .||::|.:.       .|.:.:||
Human  1185 RT-----------------QAKVAEELG-------MQEYAITN---------------------- 1203

  Fly  1575 DMTELPHANKCISQEAEKGVPPKGEFNMSTNVDVPKALGDVLEALIAAVYLDCRDLQRTWEVIFN 1639
            |.|:.|.|.:                        .|.|.|:||:.|||:|:| :||:.....:..
Human  1204 DKTKRPVALR------------------------TKTLADLLESFIAALYID-KDLEYVHTFMNV 1243

  Fly  1640 LFEPELQEFTRK-------------------------VPINHIRQLVEHKHAKPVFSSPIVEGET 1679
            .|.|.|:||...                         :|:....|.|...||:....:...:||
Human  1244 CFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGE- 1307

  Fly  1680 VMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQQ 1716
             .:.|            |.|.:..||::.||..||::
Human  1308 -RIGC------------GKGPSIQQAEMGAAMDALEK 1331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	MPH1	6..542	CDD:224036	10/57 (18%)
		DEXDc	22..173	CDD:238005
		Dicer_PBD	241..343	CDD:277191
		HELICc	<438..495	CDD:197757	1/4 (25%)
		Dicer_dimer	572..665	CDD:281376	28/147 (19%)
		PAZ	843..1004	CDD:198017	41/218 (19%)
		RIBOc	1194..1391	CDD:238333	29/196 (15%)
		Rnc	1433..1719	CDD:223644	72/310 (23%)
		RIBOc	1448..1649	CDD:238333	52/201 (26%)
		dsrm	1653..1717	CDD:278464	16/64 (25%)
DROSHA	NP_001369437.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..95
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..406		30/171 (18%)
		U2AF_lg	217..>317	CDD:273727	12/76 (16%)
		Necessary for interaction with DGCR8 and pri-miRNA processing activity. /evidence=ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718	390..1365		230/1311 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..497		9/60 (15%)
		RIBOc	959..1079	CDD:238333	33/220 (15%)
		rnc	1105..1333	CDD:234633	72/312 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810