DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-2 and dcr1

DIOPT Version :9

Sequence 1:NP_523778.2 Gene:Dcr-2 / 36993 FlyBaseID:FBgn0034246 Length:1722 Species:Drosophila melanogaster
Sequence 2:NP_588215.2 Gene:dcr1 / 2538930 PomBaseID:SPCC188.13c Length:1374 Species:Schizosaccharomyces pombe


Alignment Length:1810 Identity:374/1810 - (20%)
Similarity:658/1810 - (36%) Gaps:591/1810 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPI---ESG---GKRALFMCNTV 67
            |.||..:.:..:|.|.::.:.||:|||.:|:.::|   |..::.|   ||.   .|.::|:.|.|
pombe    13 RKYQQDVYNIASKQNTLLVMRTGAGKTLLAVKLIK---QKLEEQILIQESNLEHKKISVFLVNKV 74

  Fly    68 ELARQQAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVTQTYVALSS 132
            .|..|||..:|.....|||.:.||..: :.:..:.::.|.|..|:|.||.:|...:.:.:::::.
pombe    75 PLVFQQAEYIRSQLPAKVGMFYGELSI-EMSEQLLTNIILKYNVIVITADLFYLFLARGFLSIND 138

  Fly   133 LSVVIIDECHHGTGHHPFREFMRLFTIANQTK---------LPRVVGLTGVLIKGNEITNVATKL 188
            |:::|.|||||..|:..:...|..|  .::.|         |||:.|:|.....|.: .|:..:|
pombe   139 LNLIIFDECHHAIGNDAYARIMNDF--YHRAKAVLSKKHFTLPRIFGMTASPFTGKK-GNLYHRL 200

  Fly   189 KELEITYRGNIITVSDTK-------EMENVMLYATK----PTEVMVSFPHQEQVLTVTRLISAEI 242
            .:.|..:......||:.:       ..|:.::|:.|    |::.::.  ..|:.|...:|||..:
pombe   201 YQWEQLFDSKAHVVSENELADYFCLPEESYVMYSNKLVVPPSDSIIK--KCEETLQGCKLISRAV 263

  Fly   243 EKFYVSLDLMNIGVQPIRRSKSLQCLRDPSKKSFVKQLFNDFLYQMKEYGIYAASIAIISLIVEF 307
                                           |:.:.:..:..|:..::..:|         :|:|
pombe   264 -------------------------------KTALAETIDMGLWFGEQVWLY---------LVDF 288

  Fly   308 -DIKRRQAETLSVKLMHRTALTLCEKIRHLLVQKLQDMTYDDDDDNV---NTEEVIMNFSTPKVQ 368
             :.||.:.:.|..:|.....|.: :::: :.|:..::..|.|:...:   ::.:|     |.||.
pombe   289 VETKRLKKKALGKQLSDDEELAI-DRLK-IFVEDWKNNKYSDNGPRIPVFDSTDV-----TDKVF 346

  Fly   369 RFLMSLKVSFADKDPKDICCLVFVERRYTCKCIYGLLLNYIQSTPELRNVLTPQFMVGRNNISPD 433
            :.|..||.::...|  .:..::||||:.|     ...|:....|..|.|:....|:....:...:
pombe   347 KLLELLKATYRKSD--SVRTVIFVERKAT-----AFTLSLFMKTLNLPNIRAHSFIGHGPSDQGE 404

  Fly   434 FESVLERKWQKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFILDPVKTFNMYVQSKGRARTT 498
            |.....|  ||..:.:|:.|..|::|.::|.||||||.:||.|...:..:|...||||:||||..
pombe   405 FSMTFRR--QKDTLHKFKTGKYNVLIATAVAEEGIDVPSCNLVIRFNICRTVTQYVQSRGRARAM 467

  Fly   499 EAKFVLFTADKEREKTIQQIYQYRKAHNDIAEYLKDRVLEKTEPELY-----EIKGHFQDDIDPF 558
            .:||::|.      .|.:.:...|..|.:  :.||..:.|.:...::     |.:....|||...
pombe   468 ASKFLIFL------NTEELLIHERILHEE--KNLKFALSELSNSNIFDSLVCEERERVTDDIVYE 524

  Fly   559 TNENGAVLLPNNALAILHRYCQTIPTDAFGFVIPWFHVLQEDERDRIFGVSAKGKHVISINMPVN 623
            ..|.||:|....|:::|:.:|.|:..|.:....|.|....          ...|.:...:.:|..
pombe   525 VGETGALLTGLYAVSLLYNFCNTLSRDVYTRYYPTFTAQP----------CLSGWYCFEVELPKA 579

  Fly   624 CMLRDTIYSDPMDNVKTAKISAAFKACKVLYSLGELNERFVPKTLKERVASIADVHFEHWNKYGD 688
            |.: ......|..:::.||.:|||..|..|..:|.:::...|...:.::|.:..:          
pombe   580 CKV-PAAQGSPAKSIRKAKQNAAFIMCLDLIRMGLIDKHLKPLDFRRKIADLETL---------- 633

  Fly   689 SVTATVNKADKSKDRTYKTECPLEFYDALPRVGEICYAYEIFLE-PQ-----FESCEYTEHMYLN 747
                   :.|:.||..|     :|.|:.        |..:.::: |:     |.|..||:     
pombe   634 -------EEDELKDEGY-----IETYER--------YVPKSWMKVPEDITRCFVSLLYTD----- 673

  Fly   748 LQTPRNYAILLRNKLPRLAEMPLFSNQGKLHVRVANAPLEVIIQNSEQLELLHQFHGMVFRDILK 812
                                    :|:|..|:                      ||.:||...  
pombe   674 ------------------------ANEGDNHI----------------------FHPLVFVQA-- 690

  Fly   813 IWHPF-----FVLDR----RSK------ENSYLVVPLILGAGEQKCFDWELMTNFRRLPQSHGSN 862
              |.|     |:|:.    |.|      |:|:.:...:|          ||:....|.....|.:
pombe   691 --HSFPKIDSFILNSTVGPRVKIVLETIEDSFKIDSHLL----------ELLKKSTRYLLQFGLS 743

  Fly   863 VQQREQQPAPRPEDFEGKIVTQWYANYDKPMLVTKVHRELTPLSYMEK-NQQDKTYYEFTMSKYG 926
            ....:|.|.|           .|.|         .::...|...::|. ...|.....|.:.:..
pombe   744 TSLEQQIPTP-----------YWLA---------PLNLSCTDYRFLENLIDVDTIQNFFKLPEPV 788

  Fly   927 NRIGDVVHKDKFMIEVRDLTEQLTF--YVHNRGKFNAKSKAKMKVILIPELCFNFNFPGDLWLKL 989
            ..:.|:......::..:.:.||..|  :|::.....||.|.|....|..:|....|:  .||   
pombe   789 QNVTDLQSDTVLLVNPQSIYEQYAFEGFVNSEFMIPAKKKDKAPSALCKKLPLRLNY--SLW--- 848

  Fly   990 IFLPSILNRMYFLLHAEALRKRFNTYLN-LHLLPFNGTDYMPRPLEIDYSLKRNVDPLGNVIPTE 1053
                  .||...:..::.:|   :.|:| |::||            :...||.:           
pombe   849 ------GNRAKSIPKSQQVR---SFYINDLYILP------------VSRHLKNS----------- 881

  Fly  1054 DIEEPKSLLEPMPTKSIEASVANLEITEFENPWQKYMEPVDLSRNLLSTYPVELDYYYHF----S 1114
                  :||.|.....||                          |||    |...:..||    .
pombe   882 ------ALLIPSILYHIE--------------------------NLL----VASSFIEHFRLDCK 910

  Fly  1115 VGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPALMPSKPTVRGKVKPLLILQK 1179
            :...|:                                                           
pombe   911 IDTACQ----------------------------------------------------------- 916

  Fly  1180 TVSKEHITPAEQGEFLAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEGTLTEVK 1244
                             |:|::.:...||.:|||..||.||||.|::.:..|:.|..|..|...:
pombe   917 -----------------ALTSAESQLNFDYDRLEFYGDCFLKLGASITVFLKFPDTQEYQLHFNR 964

  Fly  1245 SKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAKIIGPHNLRD 1309
            .|::||.||....||.::||...:.....|: |.|.|                |.|         
pombe   965 KKIISNCNLYKVAIDCELPKYALSTPLEIRH-WCPYG----------------FQK--------- 1003

  Fly  1310 LALGDEESLVKGNCSDINYNRFVEGCRANGQSFYAGADFSSEVNFCVGLVTIPNKVIADTLEALL 1374
                        :.||        .||      ||            .|..:..|.|||.:||.:
pombe  1004 ------------STSD--------KCR------YA------------VLQKLSVKRIADMVEASI 1030

  Fly  1375 GVIVKNYGLQHAFKMLEYFKICRADIDKPLTQLLNLELGGKKMRANVNTTEIDGFL-INHY---- 1434
            |..:.:.||..|.|:.:...:...||.                    |..|.:.:. :|.|    
pombe  1031 GACLLDSGLDSALKICKSLSVGLLDIS--------------------NWDEWNNYFDLNTYADSL 1075

  Fly  1435 ---------YLEKNLGYTFKDRRYLLQALTHPSYPTNR-ITGSYQELEFIGDAILDFLISAYIFE 1489
                     |:|:.:||:||:::.|..|..|||..:.: |..:||:|||:|||:||::|..|:::
pombe  1076 RNVQFPYSSYIEETIGYSFKNKKLLHLAFIHPSMMSQQGIYENYQQLEFLGDAVLDYIIVQYLYK 1140

  Fly  1490 NNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVNFQESQGHRVTNYV 1554
            .......|.|||.:|..|.|.:|:.|.....||.:|..|:|.:.:.|   ..:||        .:
pombe  1141 KYPNATSGELTDYKSFYVCNKSLSYIGFVLNLHKYIQHESAAMCDAI---FEYQE--------LI 1194

  Fly  1555 RILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNVDVPKALGDVLEAL 1619
            ....|.|...|.                                   ....:|.||.:.|.|||:
pombe  1195 EAFRETASENPW-----------------------------------FWFEIDSPKFISDTLEAM 1224

  Fly  1620 IAAVYLDCRDLQRTWEVIFNLFEPELQEFTR---KVPINH-IRQLVEHKHAKPVFSSPIVEGETV 1680
            |.|::||.....::.:.:..||...|.:.|.   |..|.| :.||::.:..:...:..::|    
pombe  1225 ICAIFLDSGFSLQSLQFVLPLFLNSLGDATHTKAKGDIEHKVYQLLKDQGCEDFGTKCVIE---- 1285

  Fly  1681 MVSCQFTCMEKTI--------KVYGF-----------GSNKDQAKLSAAKHALQQ 1716
                :.....||:        |.|||           |.::   |::.||:.::|
pombe  1286 ----EVKSSHKTLLNTELHLTKYYGFSFFRHGNIVAYGKSR---KVANAKYIMKQ 1333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-2NP_523778.2 MPH1 6..542 CDD:224036 135/562 (24%)
DEXDc 22..173 CDD:238005 48/165 (29%)
Dicer_PBD 241..343 CDD:277191 11/102 (11%)
HELICc <438..495 CDD:197757 23/56 (41%)
Dicer_dimer 572..665 CDD:281376 18/92 (20%)
PAZ 843..1004 CDD:198017 29/163 (18%)
RIBOc 1194..1391 CDD:238333 51/196 (26%)
Rnc 1433..1719 CDD:223644 77/321 (24%)
RIBOc 1448..1649 CDD:238333 52/201 (26%)
dsrm 1653..1717 CDD:278464 16/84 (19%)
dcr1NP_588215.2 MPH1 1..501 CDD:224036 135/560 (24%)
DEXDc 26..188 CDD:238005 49/167 (29%)
Helicase_C 343..464 CDD:278689 40/129 (31%)
Dicer_dimer 538..620 CDD:281376 18/92 (20%)
RIBOc 912..1045 CDD:197778 51/272 (19%)
Rnc 1076..1345 CDD:223644 76/315 (24%)
RIBOc 1098..1247 CDD:238333 50/194 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 69 1.000 Domainoid score I2712
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 299 1.000 Inparanoid score I607
OMA 1 1.010 - - QHG57860
OrthoFinder 1 1.000 - - FOG0002051
OrthoInspector 1 1.000 - - otm47000
orthoMCL 1 0.900 - - OOG6_101152
Panther 1 1.100 - - O PTHR14950
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1728
TreeFam 1 0.960 - -
1211.830

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