Protein Alignment Dcr-2 and DICER1

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_085124.2
• Gene: DICER1 / 23405
• HGNCID: 17098
• Length: 1922
• Species: Homo sapiens
• Alignment Length: 2019
• Identity: 526/2019 - (26%)
• Similarity: 868/2019 - (42%)
• Gaps: 459/2019 - (22%)

  Fly     8 PRGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVELARQ 72
            ||.||:.|::.....|.||.|.|||||||:|:|:.|..|..........|||.:|:.|:.....|
Human    44 PRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVNSANQVAQ 108

  Fly    73 QAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVTQTYVALSSLSVVI 137
            |..|||..::.|||.|...:....||:..|:.|..|:|||:.|..|.|:::...|::||.:::::
Human   109 QVSAVRTHSDLKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLV 173

  Fly   138 IDECHHGTGHHPFREFMRLFTIANQTKLPRVVGLTGVLIKGN-EITNVATKLKELEITYRGNIIT 201
            .||||.....||:||.|:|  ..|....||::|||..::.|. :...:..|:::||...:.|..|
Human   174 FDECHLAILDHPYREIMKL--CENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAET 236

  Fly   202 VSDTKEMENVMLYATKPTEVMVSF-PHQEQVLTVTRLISAEIEKFYVSLDLMNIGVQPIRRSKSL 265
            .:|...::.   |.::|.|::|.. |..::.....||: .|:|:....::..||.|....|..:|
Human   237 ATDLVVLDR---YTSQPCEIVVDCGPFTDRSGLYERLL-MELEEALNFINDCNISVHSKERDSTL 297

  Fly   266 QCLRDPSKKSFVKQLFNDFLYQMKEYGIYAASIAIISLIVEFD--IKRRQAETLSVKLMHRTAL- 327
                      ..||:.:|....:...|.:.|......::.|..  ||..|.|      :||..|
Human   298 ----------ISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEE------LHRKFLL 346

  Fly   328 ---TLCEKIRHLLVQKLQDMTYDDDDDNVNTEEVIMNFSTPKVQRFLMSLK-------------- 375
               |...||..|..:.....:.|            :.|.||||.:.|..|:
Human   347 FTDTFLRKIHALCEEHFSPASLD------------LKFVTPKVIKLLEILRKYKPYERQQFESVE 399

  Fly   376 ----------VSFADKDPKD----------------------ICCLVFVERRYTCKCIYGLLLNY 408
                      ||::|.:..|                      :|.::|||||||...:..|:...
Human   400 WYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEA 464

  Fly   409 IQSTPELRNVLTPQFMVGR---NNISPDFESVLERKWQKSAIQQFRDGNANLMICSSVLEEGIDV 470
            .:..|||. .::..|:.|.   .|...:.:...|.:.|:..:::||....||:|.:|::|||:|:
Human   465 GKQDPELA-YISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDI 528

  Fly   471 QACNHVFILDPVKTFNMYVQSKGRARTTEAKFVLFTADKEREKTIQQIYQYRKAHNDIAEYLKDR 535
            ..||.|...|....:..|||||||||...:.:::. ||.::.|:.::..:..||   |.:.|:::
Human   529 PKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIML-ADTDKIKSFEEDLKTYKA---IEKILRNK 589

  Fly   536 VLEKTEPELYEIKGHFQDDIDPFTNENGA----VLLP---------NNALAILHRYCQTIPTDAF 587
            ..:..:..        :.||||..:::..    ||.|         |.|:..::|||..:|:|.|
Human   590 CSKSVDTG--------ETDIDPVMDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPF 646

  Fly   588 GFVIPWFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRDTIYSDPMDNVKTAKISAAFKACKV 652
            ..:.|.....:..:          |....::.:|:|..||.:|...||..|:.|:...|...|:.
Human   647 THLAPKCRTRELPD----------GTFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEK 701

  Fly   653 LYSLGELNERFVP---KTLKERVASIADVHFEHWNKYGDSVTATVNKADKSKDR-TYKTECPLEF 713
            |:.:|||::..:|   :|:|         :.|..:.:.:..|:...:...:|.| .|....|...
Human   702 LHKIGELDDHLMPVGKETVK---------YEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECL 757

  Fly   714 YDALPRVGEICYAYEI---FLEPQFESCEYTEH-MYLNLQTPRNYAILLRNKLPRLAEMPLFSNQ 774
            .|:.||..:.||.|.|   ...|..:...:... :|....|.|.:.||....:|::...|:::..
Human   758 RDSYPRPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRS 822

  Fly   775 GKLHVRVANAPLEVIIQNSEQLELLHQFHGMVFRDILKIWHPFFVLDRRSKENSYLVVPL-ILGA 838
            |::.:.: .......:.:.:.|||:.:.|..:|..||::..|.........:::|.|:|| ::..
Human   823 GEVTISI-ELKKSGFMLSLQMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVND 886

  Fly   839 GEQKCFDWELMTNFRRLPQSHG--SNVQQREQQPAPRPEDFEGKIVTQWYANYDKP--MLVTKVH 899
            ......|::.|.:..:.....|  |....:|.....:.||::..::...|.|:|:|  ..|..|:
Human   887 SSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVY 951

  Fly   900 RELTPLSYMEKNQQDKTYYEFTMSKYGNRIGDVVHKDKFMIEVRDLTEQLTF----YVHNRGK-- 958
            .:|||||.....:.: |:.|:..:||..   |:.:.::.:::|...:.:|..    :::.:||
Human   952 TDLTPLSKFPSPEYE-TFAEYYKTKYNL---DLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKAL 1012

  Fly   959 ---FNAKSKAKM-----KVILIPELCFNFNFPGDLWLKLIFLPSILNRMYFLLHAEALRKR--FN 1013
               ...|.|||.     |.||:||||.....|..||.|.:.|||||.|::.||.||.||.:  .:
Human  1013 PLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASD 1077

  Fly  1014 TYLNLHLLPFNGTDYMPRPLEIDYSLKRNVD-----PLGNVIPTEDIEEPK-SLLEP-------- 1064
            ..:.:..||   .|:  |...:|:..|:::|     .:.|....|:....| |.:.|
Human  1078 AGVGVRSLP---ADF--RYPNLDFGWKKSIDSKSFISISNSSSAENDNYCKHSTIVPENAAHQGA 1137

  Fly  1065 MPTKSIE----ASVANLEITEFENPWQKYME-PVDLSR-NLLSTYPVELDYYYHFSVGNVCEMNE 1123
            ..|.|:|    .|| |......|:|.:.::| ..||:. |.||......:..|..:..:.|:.|:
Human  1138 NRTSSLENHDQMSV-NCRTLLSESPGKLHVEVSADLTAINGLSYNQNLANGSYDLANRDFCQGNQ 1201

  Fly  1124 MDFEDKE--------------YWAKNQFHMPT------GNIY--GNRTPAKTNAN-VPALMPSKP 1165
            :::..:|              |..:|| ..|:      .|.|  ||...:.::.: |.|:||
Human  1202 LNYYKQEIPVQPTTSYSIQNLYSYENQ-PQPSDECTLLSNKYLDGNANKSTSDGSPVMAVMP--- 1262

  Fly  1166 TVRGKVKPLLILQKTVSKEHITPA----------EQGEFLAAITASSAADVFDMERLEILGDSFL 1220
               |....:.:|:..:..|. :|:          ..|..|.|:|.|:|:|.|::||||:||||||
Human  1263 ---GTTDTIQVLKGRMDSEQ-SPSIGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFL 1323

  Fly  1221 KLSATLYLASKYSDWNEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPPG--IS 1283
            |.:.|.||...|.|.:||.|:.::||.|||.||........:|..:....|.|...|||||  ::
Human  1324 KHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVN 1388

  Fly  1284 LPHNVLALWRENPEFAKIIGPHNLRDLALG-------------DEESLV------KGNCSD--IN 1327
            ...:....| |..|..|        |..|.             :||||:      :.:..|  :.
Human  1389 QDKSNTDKW-EKDEMTK--------DCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYEDDFLE 1444

  Fly  1328 YN----RFVEGCRANGQSF----------------------------------YAGADFSS---- 1350
            |:    ||::.......:|                                  :...|:||
Human  1445 YDQEHIRFIDNMLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFEDFDYSSWDAM 1509

  Fly  1351 ----------EVNFCVGL------------------------VTIPNKVIADTLEALLGVIVKNY 1381
                      |.:|.||.                        ..|.:|.|||.:|||||..:.:.
Human  1510 CYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSC 1574

  Fly  1382 GLQHA--------FKMLEYFKICRADIDKPL--------TQLLNL-------------------- 1410
            |.:.|        .|:|...|  |.|.:|.|        :|..||
Human  1575 GERAAQLFLCSLGLKVLPVIK--RTDREKALCPTRENFNSQQKNLSVSCAAASVASSRSSVLKDS 1637

  Fly  1411 ELGGKKM--RANVNTTEIDGFLINHYY-----LEKNLGYTFKDRRYLLQALTHPSYPTNRITGSY 1468
            |.|..|:  |...:..:.|..| ||..     .||.:.|.||::.|||||.||.||..|.||..|
Human  1638 EYGCLKIPPRCMFDHPDADKTL-NHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCY 1701

  Fly  1469 QELEFIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLS 1533
            |.|||:||||||:||:.:::|:..:.:||.||||||||||||..|.:.|::..|.:..|.:.:|.
Human  1702 QRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELF 1766

  Fly  1534 EIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKG 1598
            .:|..||.||              ||:.::|    .:|.||..:|         ::.||
Human  1767 HVIDDFVQFQ--------------LEKNEMQ----GMDSELRRSE---------EDEEK------ 1798

  Fly  1599 EFNMSTNVDVPKALGDVLEALIAAVYLDC-RDLQRTWEVIFNLFEPELQEFTRKVPINHIRQLVE 1662
                ..:::||||:||:.|:|..|:|:|. ..|:..|:|.:.:..|.:::|:..||.:.:|:|:|
Human  1799 ----EEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLE 1859

  Fly  1663 HKHAKPVFSSPIVEGETVMVSCQFTCMEK--------TIKVYGFGSNKDQ------AKLSAAKHA 1713
                        :|.||    .:|:..|:        |::|.|.|..|..      ||.:||:.|
Human  1860 ------------MEPET----AKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRA 1908

  Fly  1714 LQQL 1717
            |:.|
Human  1909 LRSL 1912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792	70/196 (36%)
		Dicer_PBD	241..343	CDD:277191	24/107 (22%)
		SF2_C_dicer	360..506	CDD:350189	51/194 (26%)
		Dicer_dimer	571..670	CDD:460900	26/101 (26%)
		PAZ	843..1004	CDD:198017	49/178 (28%)
		RIBOc	1194..1391	CDD:238333	76/303 (25%)
		RIBOc	1448..1649	CDD:238333	74/201 (37%)
		dsrm	1653..1717	CDD:425434	20/77 (26%)
DICER1	NP_085124.2	DEXHc_dicer	42..239	CDD:350792	70/196 (36%)
		DECH box	175..178		2/2 (100%)
		Required for interaction with PRKRA and TARBP2	256..595		86/372 (23%)
		Dicer_PBD	271..365	CDD:277191	24/110 (22%)
		SF2_C_dicer	372..564	CDD:350189	51/193 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..433		4/23 (17%)
		Dicer_dimer	630..718	CDD:460900	25/97 (26%)
		PAZ_dicer_like	886..1008	CDD:239209	25/125 (20%)
		RIBOc	1296..>1387	CDD:197778	41/90 (46%)
		RIBOc	1682..1846	CDD:238333	74/200 (37%)
		DSRM_DICER	1851..1913	CDD:380680	20/78 (26%)