Protein Alignment Dcr-2 and Dicer1

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_001398758.1
• Gene: Dicer1 / 192119
• MGIID: 2177178
• Length: 1916
• Species: Mus musculus
• Alignment Length: 2009
• Identity: 514/2009 - (25%)
• Similarity: 857/2009 - (42%)
• Gaps: 445/2009 - (22%)

  Fly     8 PRGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVELARQ 72
            ||.||:.|::.....|.||.|.|||||||:|:|:.|..:......:....||.:|:.|:.....|
Mouse    44 PRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLNPHAKRTVFLVNSANQVAQ 108

  Fly    73 QAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVTQTYVALSSLSVVI 137
            |..|||..::.|||.|...:....||:..||.|..|:|||:.|..|.|.::...|::||.:::::
Mouse   109 QVSAVRTHSDLKVGEYSDLEVNASWTKERWSQEFTKHQVLIMTCYVALTVLKNGYLSLSDINLLV 173

  Fly   138 IDECHHGTGHHPFREFMRLFTIANQTKLPRVVGLTGVLIKGN-EITNVATKLKELEITYRGNIIT 201
            .||||.....||:||.|:|  ..:....||::|||..::.|. :...:..|:::||...|.:..|
Mouse   174 FDECHLAILDHPYREIMKL--CESCPSCPRILGLTASILNGKCDPEELEEKIQKLERILRSDAET 236

  Fly   202 VSDTKEMENVMLYATKPTEVMVSF-PHQEQVLTVTRLISAEIEKFYVSLDLM---NIGVQPIRRS 262
            .:|...::.   |.::|.|::|.. |..::.....||: .|:|   .:||.:   |:.|....|.
Mouse   237 ATDLVVLDR---YTSQPCEIVVDCGPFTDRSGLYERLL-MELE---AALDFINDCNVAVHSKERD 294

  Fly   263 KSLQCLRDPSKKSFVKQLFNDFLYQMKEYGIYAASIAIISLIVEFD--IKRRQAETLSVKLMHRT 325
            .:|          ..||:.:|....:...|.:.|......::.|..  ||..|.|      :||.
Mouse   295 STL----------ISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEE------LHRK 343

  Fly   326 AL----TLCEKIRHLLVQKLQDMTYDDDDDNVNTEEVIMNFSTPKVQRFLMSLK----------- 375
            .|    ||..||..|..:.....:.|            :.:.||||.:.|..|:
Mouse   344 FLLFTDTLLRKIHALCEEYFSPASLD------------LKYVTPKVMKLLEILRKYKPYERQQFE 396

  Fly   376 -------------VSFADKDPKD----------------------ICCLVFVERRYTCKCIYGLL 405
                         ||::|.:..|                      :|.::|||||||...:..|:
Mouse   397 SVEWYNNRNQDNYVSWSDSEDDDDDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLI 461

  Fly   406 LNYIQSTPELRNVLTPQFM----VGRNN-ISPDFESVLERKWQKSAIQQFRDGNANLMICSSVLE 465
            ....:..|||. .::..|:    :|:|. .|...|:  |.:.|:..:::||....||:|.:||:|
Mouse   462 KEAGKQDPELA-YISSNFITGHGIGKNQPRSKQMEA--EFRKQEEVLRKFRAHETNLLIATSVVE 523

  Fly   466 EGIDVQACNHVFILDPVKTFNMYVQSKGRARTTEAKFVLFTADKEREKTIQQIYQYRKAHNDIAE 530
            ||:|:..||.|...|....:..|||||||||...:.:|:. ||.::.|:.::..:..||   |.:
Mouse   524 EGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVML-ADTDKIKSFEEDLKTYKA---IEK 584

  Fly   531 YLKDRVLEKTEPELYEIKGHFQDDIDPF------TNENGAVLLPNNALAILHRYCQTIPTDAFGF 589
            .|:::..:..:....::.... ||.|.|      .::.|..:..|.|:..::|||..:|:|.|..
Mouse   585 ILRNKCSKSADGAEADVHAGV-DDEDAFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTH 648

  Fly   590 VIPWFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRDTIYSDPMDNVKTAKISAAFKACKVLY 654
            :.|.....:..:          |....::.:|:|..||.:|...|||:|:.|:...|...|:.|:
Mouse   649 LAPKCRTRELPD----------GTFYSTLYLPINSPLRASIVGPPMDSVRLAERVVALICCEKLH 703

  Fly   655 SLGELNERFVP---KTLKERVASIADVHFEHWNKYGDSVTATVNKADKSKDR-TYKTECPLEFYD 715
            .:|||:|..:|   :|:|         :.|..:.:.:..|:...:...:|.| .|....|....:
Mouse   704 KIGELDEHLMPVGKETVK---------YEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRE 759

  Fly   716 ALPRVGEICYAYEI---FLEPQFESCEYTEH-MYLNLQTPRNYAILLRNKLPRLAEMPLFSNQGK 776
            :.|:..:.||.|.|   ...|..:...:... :|....|.|.:.||....:|::...|:::..|:
Mouse   760 SYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGE 824

  Fly   777 LHVRVANAPLEVIIQNSEQLELLHQFHGMVFRDILKIWHPFFVLDRRSKENSYLVVPL-ILGAGE 840
            :.:.: .........:.:.|||:.:.|..:|..||::..|.........|::|.|:|| ::....
Mouse   825 VTISI-ELKKSGFTLSQQMLELITRLHQYIFSHILRLEKPALEFKPTGAESAYCVLPLNVVNDSG 888

  Fly   841 QKCFDWELMTNFRRLPQSHG--SNVQQREQQPAPRPEDFEGKIVTQWYANYDKP--MLVTKVHRE 901
            ....|::.|.:..:.....|  |....:|.....:.||::..::...|.|:|:|  ..|..|:.:
Mouse   889 TLDIDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTD 953

  Fly   902 LTPLSYMEKNQQDKTYYEFTMSKYGNRIGDVVHKDKFMIEVRDLTEQLTF----YVHNRGK---- 958
            |||||.....:.: |:.|:..:||..   |:.:.::.:::|...:.:|..    :::.:||
Mouse   954 LTPLSKFPSPEYE-TFAEYYKTKYNL---DLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPL 1014

  Fly   959 -FNAKSKAKM-----KVILIPELCFNFNFPGDLWLKLIFLPSILNRMYFLLHAEALRKR--FNTY 1015
             ...|.|||.     |.||:||||.....|..||.|.:.|||||.|::.||.||.||.:  .:..
Mouse  1015 SSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAG 1079

  Fly  1016 LNLHLLPFNGTDYMPRPLEIDYSLKRNVDPLG--------------------NVIPTEDIEEPKS 1060
            :.:..||   .|:  |...:|:..|:::|...                    .|:|.....:  .
Mouse  1080 VGVRSLP---VDF--RYPNLDFGWKKSIDSKSFISSCNSSLAESDNYCKHSTTVVPEHAAHQ--G 1137

  Fly  1061 LLEPMPTKSIEASVANLEITEFENPWQKYME-PVDLSR-NLLSTYPVELDYYYHFSVGN------ 1117
            ...|......:.|| |.:....|:|.:...| ..||:. |.||         |:.::.|
Mouse  1138 ATRPSLENHDQMSV-NCKRLPAESPAKLQSEVSTDLTAINGLS---------YNKNLANGSYDLV 1192

  Fly  1118 ---VCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPAL----------------MPS 1163
               .|:.|::::..:|...:.....|..|:|......|.:...|.|                .|:
Mouse  1193 NRDFCQGNQLNYFKQEIPVQPTTSYPIQNLYNYENQPKPSNECPLLSNTYLDGNANTSTSDGSPA 1257

  Fly  1164 KPTVRGKVKPLLILQKTVSKEHITPA----------EQGEFLAAITASSAADVFDMERLEILGDS 1218
            ..|:...:..:..|:..:..|. :|:          ..|..|.|:|.|:|:|.|::||||:||||
Mouse  1258 VSTMPAMMNAVKALKDRMDSEQ-SPSVGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDS 1321

  Fly  1219 FLKLSATLYLASKYSDWNEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPPGIS 1283
            |||.:.|.||...|.|.:||.|:.::||.|||.||........:|..:....|.|...|||||..
Mouse  1322 FLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYV 1386

  Fly  1284 LPHN----------------VLA--------------LWRENPEFAKIIGPHNLRDLALGDEE-- 1316
            :..:                :||              .||...|.|:     :..|....|:|
Mouse  1387 VNQDKSNSEKWEKDEMTKDCLLANGKLGEACEEEEDLTWRAPKEEAE-----DEDDFLEYDQEHI 1446

  Fly  1317 ----SLVKG-------------NCSDINYN-RFVEGCRANGQSFYAGA---DFSS---------- 1350
                |::.|             :.||..|. :..:........|.:|.   |:||
Mouse  1447 QFIDSMLMGSGAFVRKISLSPFSASDSAYEWKMPKKASLGSMPFASGLEDFDYSSWDAMCYLDPS 1511

  Fly  1351 ----EVNFCVGL------------------------VTIPNKVIADTLEALLGVIVKNYGLQHA- 1386
                |.:|.||.                        ..|.:|.|||.:|||||..:.:.|.:.|
Mouse  1512 KAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQ 1576

  Fly  1387 -------FKMLEYFK------------------------ICRADIDKPLTQLLNLELGGKKM--R 1418
                   .|:|...|                        .|.:.:....:...:||.|..|:  |
Mouse  1577 LFLCSLGLKVLPVIKRTSREKALDPAQENGSSQQKSLSGSCASPVGPRSSAGKDLEYGCLKIPPR 1641

  Fly  1419 ANVNTTEIDGFLINHYY-----LEKNLGYTFKDRRYLLQALTHPSYPTNRITGSYQELEFIGDAI 1478
            ...:..:.:..| ||..     .||.:.|.||::.|||||.||.||..|.||..||.|||:||||
Mouse  1642 CMFDHPDAEKTL-NHLISGFETFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAI 1705

  Fly  1479 LDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVNFQ 1543
            ||:||:.:::|:..:.:||.||||||||||||..|.:.|::..|.:..|.:.:|..:|..||.||
Mouse  1706 LDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVKFQ 1770

  Fly  1544 ESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNVDV 1608
                          ||:.::|    .:|.||..:|         ::.||          ..:::|
Mouse  1771 --------------LEKNEMQ----GMDSELRRSE---------EDEEK----------EEDIEV 1798

  Fly  1609 PKALGDVLEALIAAVYLDC-RDLQRTWEVIFNLFEPELQEFTRKVPINHIRQLVEHKHAKPVFSS 1672
            |||:||:.|:|..|:|:|. ..|:..|:|.:.:.:|.:::|:..||.:.:|:|:|
Mouse  1799 PKAMGDIFESLAGAIYMDSGMSLEVVWQVYYPMMQPLIEKFSANVPRSPVRELLE---------- 1853

  Fly  1673 PIVEGETVMVSCQFTCMEK--------TIKVYGFGSNKDQ------AKLSAAKHALQQL 1717
              :|.||    .:|:..|:        |::|.|.|..|..      ||.:||:.||:.|
Mouse  1854 --MEPET----AKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSL 1906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792	68/196 (35%)
		Dicer_PBD	241..343	CDD:277191	26/110 (24%)
		SF2_C_dicer	360..506	CDD:350189	54/196 (28%)
		Dicer_dimer	571..670	CDD:460900	28/101 (28%)
		PAZ	843..1004	CDD:198017	49/178 (28%)
		RIBOc	1194..1391	CDD:238333	77/295 (26%)
		RIBOc	1448..1649	CDD:238333	74/201 (37%)
		dsrm	1653..1717	CDD:425434	20/77 (26%)
Dicer1	NP_001398758.1	DEXHc_dicer	42..239	CDD:350792	68/196 (35%)
		DECH box	175..178		2/2 (100%)
		Required for interaction with PRKRA and TARBP2. /evidence=ECO:0000250	256..595		91/377 (24%)
		Dicer_PBD	271..365	CDD:277191	26/113 (23%)
		SF2_C_dicer	372..564	CDD:350189	54/195 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..433		4/23 (17%)
		Dicer_dimer	630..718	CDD:460900	27/97 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	726..745		1/18 (6%)
		PAZ_dicer_like	886..1008	CDD:239209	25/125 (20%)
		RIBOc	1296..>1387	CDD:197778	41/90 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1598..1626		1/27 (4%)
		RIBOc	1676..1840	CDD:238333	74/200 (37%)
		DSRM_DICER	1845..1907	CDD:380680	20/78 (26%)