DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-2 and dcr-1

DIOPT Version :9

Sequence 1:NP_523778.2 Gene:Dcr-2 / 36993 FlyBaseID:FBgn0034246 Length:1722 Species:Drosophila melanogaster
Sequence 2:NP_498761.2 Gene:dcr-1 / 176138 WormBaseID:WBGene00000939 Length:1910 Species:Caenorhabditis elegans


Alignment Length:2078 Identity:517/2078 - (24%)
Similarity:861/2078 - (41%) Gaps:556/2078 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PRGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVELARQ 72
            ||.||:.|:|..||.|.||.|.|||||||:|:|:||.:......|::.|||||.|:...|.|..|
 Worm    13 PRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVEKVNLVEQ 77

  Fly    73 QAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDE------IKKNQVLVGTAQVFLDMVTQTYVALS 131
            ||:.:...|:||||...|:.     :.|:|..:      :|::.|:|.|||..||::...|:.:.
 Worm    78 QAIHIEVHTSFKVGQVHGQT-----SSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIRHAYLKIE 137

  Fly   132 SLSVVIIDECHHGTG-HHPFREFMRLFTIANQTK-LPRVVGLTGVLIKGNEI-TNVATKLKELEI 193
            .:.|:|.|||||..| .||:|..|..:.:..:.| :|||:|||..|||.... ..:..:||:||.
 Worm   138 DMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVAPEKLMEQLKKLES 202

  Fly   194 TYRGNIITVSDTKEMENVMLYATKPTEVMV----------SFPHQEQVLTV----TRLISAEIEK 244
            .....|.|.||   :.::..|..||.||::          ..|:.:.|:.:    ...::...| 
 Worm   203 AMDSVIETASD---LVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIEIFDETVAFVNTTTE- 263

  Fly   245 FYVSLDLMNIGVQPIRRS-----------------KSLQCLRDPSKKSFVKQLFND----FLYQM 288
            |:..|||  ...:||:.|                 ::.|.......|....|:..|    ||...
 Worm   264 FHPDLDL--DPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKIIKSQVLPDKTLRFLNMA 326

  Fly   289 KEYGIYAASIAIISLIVEFDIKRRQAETLSVKLMHRTALTLCEKIRHLLVQKLQDMTYDDDDDNV 353
            |      .|:..|..::|.::|:               :...|.:|..:.|::           :
 Worm   327 K------TSMITIKRLLEPEMKK---------------IKSIEALRPYVPQRV-----------I 359

  Fly   354 NTEEVIMNFSTPKVQRFLMSLKVSFADKDPKDICCLVFVERRYTCKCIYGLLL--NYIQSTPELR 416
            ...|::..|: |:.|:..|.|:.:      :.:..::||::||..   |.|||  .:|:|.....
 Worm   360 RLFEILETFN-PEFQKERMKLEKA------EHLSAIIFVDQRYIA---YSLLLMMRHIKSWEPKF 414

  Fly   417 NVLTPQFMV---GRNNISPDFESVLERKWQKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFI 478
            ..:.|.::|   |||..|.|.:.:.:|  |...:::|.....|.:|.:||||||:||:.||.|..
 Worm   415 KFVNPDYVVGASGRNLASSDSQGLHKR--QTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIK 477

  Fly   479 LDPVKTFNMYVQSKGRARTTEAKFVLFTADKERE------KTIQQI-----YQYRKAHNDIAEYL 532
            .|.......|||||||||...:::|:...:|:..      |..|||     .::|..:|.| |..
 Worm   478 FDRPLDMRSYVQSKGRARRAGSRYVITVEEKDTAACDSDLKDFQQIEKILLSRHRTVNNPI-EDD 541

  Fly   533 KDRVLEKTEPELYEIKGHFQDDIDPFTNE-NGAVLLPNNALAILHRYCQTIPTDAFGFVIPWFHV 596
            .||.      |.:::    ...::|:..| .||.|..:.|:|:::|||..:|:|.|..::|...:
 Worm   542 SDRF------EEFDV----DSQMEPYVVEKTGATLKMSTAIALINRYCSKLPSDIFTRLVPHNQI 596

  Fly   597 LQEDERDRIFGVSAKGKHVISINMPVNCMLRDTI-YSDPMDNVKTAKISAAFKACKVLYSLGELN 660
            :..:|.    ||:   |:...:.:|:|..::..| ..:||.|.|||:::.|.:||:.|:..|||:
 Worm   597 IPIEEN----GVT---KYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELD 654

  Fly   661 ERFVPKTLKERVASIADVHFEHWNKYGDSVTATVNKADKSKDRTYKTECPLEFYDALPRVGEICY 725
            :..:||. :|.:|.:.:...|..::|...:.|.|..:  .:.:.|..:......::.....:.|:
 Worm   655 DNLLPKG-RESIAKLLEHIDEEPDEYAPGIAAKVGSS--KRKQLYDKKIARALNESFVEADKECF 716

  Fly   726 AYEIFLEPQFESCEYTEHMYLN-----LQTPRNY----AILLRNKLPRLAEMPLFSNQGKLHVRV 781
            .|...|| :|...|.|    ||     .:.|.||    ..|...::|::...|:|..||.:.||:
 Worm   717 IYAFELE-RFREAELT----LNPKRRKFEDPFNYEYCFGFLSAKEIPKIPPFPVFLRQGNMKVRL 776

  Fly   782 ANAPLEVIIQNSEQLELLHQFHGMVFRDILKIWHP----------------FFVLDRRSKENSYL 830
            ..||.:..: .:.||:.:..||..:|..:|::...                ...|::|..:.||.
 Worm   777 IVAPKKTTV-TAAQLQEIQLFHNYLFTQVLQMCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYT 840

  Fly   831 VVPLILGAGEQKCFDWELMTNFRRLPQSHGSNVQQREQQPAPRPEDFEGKIVTQWYANYDKPML- 894
            :         ...:..|::.|...:|:.....|:::.:..|   ||::..||..||.|.::|:. 
 Worm   841 I---------NMKYVSEVVANMENMPRIPKDEVRRQYKFNA---EDYKDAIVMPWYRNLEQPVFY 893

  Fly   895 -VTKVHRELTPLSYMEKNQQDKTYYEFTMSKYGNRIGDVVHKDKFMIEV---------------- 942
             |.::..|..|.|.. .:...:|:.|:.:.||...|.|   :::.:::|                
 Worm   894 YVAEILPEWRPSSKF-PDTHFETFNEYFIKKYKLEIYD---QNQSLLDVDFTSTRLNLLQPRIQN 954

  Fly   943 -----RDLTEQLTFYVHNRGKFNAKSK------AKMKVILIPELCFNFNFPGDLWLKLIFLPSIL 996
                 |.::...|..:......::|..      :..:.||:|||.........||..:..||||.
 Worm   955 QPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVIAALPSIF 1019

  Fly   997 NRMYFLLHAEALRKR-------------------------------------------------- 1011
            .|:..||..:.||:.                                                  
 Worm  1020 YRVNQLLLTDELRETILVKAFGKEKTKLDDNVEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSI 1084

  Fly  1012 -------------------FNTYL--------------------------------NLH------ 1019
                               ||..:                                .||      
 Worm  1085 EDQERETRENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISD 1149

  Fly  1020 ---LLPFNGTDYMPRPLEIDYSLKRNVDPLG------NVIPT--EDIEEPKSLLEPMPTK----- 1068
               .|||...||..|       |..|.:.:|      :::|:  .|.:.|:....|||.:     
 Worm  1150 EDDELPFVMHDYTAR-------LTSNRNGIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILGGP 1207

  Fly  1069 ---SIEASVANL--------------------------EITEFENPWQKYMEPVDLSRNLLSTYP 1104
               :::|.:|::                          ::|:.|..::|      |..:||....
 Worm  1208 GGLNVQALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLTKEEEQFKK------LQNDLLKQAK 1266

  Fly  1105 VELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNI--YGNRTPAKTNANVPALMPSKPTV 1167
            ..|:         ..||:| |.|      |.:....|.|:  ||:....:.:.|.|...|.  |:
 Worm  1267 ERLE---------ALEMSE-DME------KPRRLEDTVNLEDYGDDQENQEDENTPTNFPK--TI 1313

  Fly  1168 RGKVKPLLI-------LQKTVSKEHITPAEQGE-------------------------------- 1193
            ..:::.|.|       :....:|..:...|..|                                
 Worm  1314 DEEIEELSIGARKKQEIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQRSE 1378

  Fly  1194 ------------------FLAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEGTL 1240
                              .|.|:|.|:|||...:||.|.:||||||.:.|.||.....|.:||.|
 Worm  1379 EYVSHIDSDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKL 1443

  Fly  1241 TEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPP------GISLPHNVLALWRENPEFA 1299
            :..:||.|||.||........||:.:...:|....:||||      ....|:...|..::| |..
 Worm  1444 SFARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCYIPTCDFKAPNTDDAEEKDN-EIE 1507

  Fly  1300 KIIG-------PHNLRDLALGDEESLVKGNCSDINYNRFVEGCRANGQSFYAGADFSSEVNFCVG 1357
            :|:.       |.|.....:|.:.|  |.....|....|.:..|       .|.|..|.:.:  .
 Worm  1508 RILDGQVIEEKPENKTGWDIGGDVS--KSTTDGIETITFPKQAR-------VGNDDISPLPY--N 1561

  Fly  1358 LVT---IPNKVIADTLEALLGVIVKNYGLQHAFKMLEYF------KICRADIDKPLTQLLNLELG 1413
            |:|   |.:|.|||.:|||:||.:...|.....|::.:.      |..::|:..||.:.::..  
 Worm  1562 LLTQQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTP-- 1624

  Fly  1414 GKKMRANVNTTEIDGFLINHY------YLEKNLGYTFKDRRYLLQALTHPSYPTNRITGSYQELE 1472
             ....|::|      ||.|.:      .||:.:||.||:|.||:||.||.||..||:||.||.||
 Worm  1625 -TNPNASLN------FLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLE 1682

  Fly  1473 FIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIIS 1537
            |:|||:||::|:.|:||::.:.:||.||||||||||||..|.:.|:.......:|....|..:|.
 Worm  1683 FLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHMIE 1747

  Fly  1538 KFV------NFQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPP 1596
            |||      ||.       ||:        :.:...:..::|:|                     
 Worm  1748 KFVKLCSERNFD-------TNF--------NAEMYMVTTEEEID--------------------- 1776

  Fly  1597 KGEFNMSTNVDVPKALGDVLEALIAAVYLDC-RDLQRTWEVIFNLFEPELQEFTRKVPINHIRQL 1660
            :|:   ..:::||||:||:.|::..|:|||. |:|..||:|||::....::......|.:.||:|
 Worm  1777 EGQ---EEDIEVPKAMGDIFESVAGAIYLDSGRNLDTTWQVIFHMMRGTIELCCANPPRSPIREL 1838

  Fly  1661 VEHKHAKPVFS--SPIVEGETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQQLSKCD 1721
            :|.:.:|..||  ..|:|...|.|:.:   :...::..|.|.|...||.:|||.||:.|.:.:
 Worm  1839 MEFEQSKVRFSKMERILESGKVRVTVE---VVNNMRFTGMGRNYRIAKATAAKRALKYLHQIE 1898

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-2NP_523778.2 MPH1 6..542 CDD:224036 172/593 (29%)
DEXDc 22..173 CDD:238005 62/158 (39%)
Dicer_PBD 241..343 CDD:277191 22/122 (18%)
HELICc <438..495 CDD:197757 23/56 (41%)
Dicer_dimer 572..665 CDD:281376 28/93 (30%)
PAZ 843..1004 CDD:198017 40/189 (21%)
RIBOc 1194..1391 CDD:238333 67/212 (32%)
Rnc 1433..1719 CDD:223644 103/300 (34%)
RIBOc 1448..1649 CDD:238333 73/207 (35%)
dsrm 1653..1717 CDD:278464 22/65 (34%)
dcr-1NP_498761.2 DEXDc 27..183 CDD:238005 63/160 (39%)
Dicer_PBD 248..343 CDD:277191 18/103 (17%)
HELICc <434..498 CDD:197757 27/65 (42%)
Dicer_dimer 572..659 CDD:281376 28/93 (30%)
PAZ_dicer_like 836..956 CDD:239209 26/135 (19%)
RIBOc 1395..1520 CDD:197778 42/125 (34%)
Rnc 1639..1900 CDD:223644 103/302 (34%)
RIBOc 1659..1824 CDD:238333 73/203 (36%)
DSRM 1834..1894 CDD:238007 21/62 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 111 1.000 Domainoid score I3938
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5945
OMA 1 1.010 - - QHG57860
OrthoDB 1 1.010 - - D126291at33208
OrthoFinder 1 1.000 - - FOG0002051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101152
Panther 1 1.100 - - O PTHR14950
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1728
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.780

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