Protein Alignment Dcr-2 and dcr-1

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_498761.2
• Gene: dcr-1 / 176138
• WormBaseID: WBGene00000939
• Length: 1910
• Species: Caenorhabditis elegans
• Alignment Length: 2078
• Identity: 517/2078 - (24%)
• Similarity: 861/2078 - (41%)
• Gaps: 556/2078 - (26%)

  Fly     8 PRGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVELARQ 72
            ||.||:.|:|..||.|.||.|.|||||||:|:|:||.:......|::.|||||.|:...|.|..|
 Worm    13 PRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVEKVNLVEQ 77

  Fly    73 QAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDE------IKKNQVLVGTAQVFLDMVTQTYVALS 131
            ||:.:...|:||||...|:.     :.|:|..:      :|::.|:|.|||..||::...|:.:.
 Worm    78 QAIHIEVHTSFKVGQVHGQT-----SSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIRHAYLKIE 137

  Fly   132 SLSVVIIDECHHGTG-HHPFREFMRLFTIANQTK-LPRVVGLTGVLIKGNEI-TNVATKLKELEI 193
            .:.|:|.|||||..| .||:|..|..:.:..:.| :|||:|||..|||.... ..:..:||:||.
 Worm   138 DMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVAPEKLMEQLKKLES 202

  Fly   194 TYRGNIITVSDTKEMENVMLYATKPTEVMV----------SFPHQEQVLTV----TRLISAEIEK 244
            .....|.|.||   :.::..|..||.||::          ..|:.:.|:.:    ...::...|
 Worm   203 AMDSVIETASD---LVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIEIFDETVAFVNTTTE- 263

  Fly   245 FYVSLDLMNIGVQPIRRS-----------------KSLQCLRDPSKKSFVKQLFND----FLYQM 288
            |:..|||  ...:||:.|                 ::.|.......|....|:..|    ||...
 Worm   264 FHPDLDL--DPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKIIKSQVLPDKTLRFLNMA 326

  Fly   289 KEYGIYAASIAIISLIVEFDIKRRQAETLSVKLMHRTALTLCEKIRHLLVQKLQDMTYDDDDDNV 353
            |      .|:..|..::|.::|:               :...|.:|..:.|::           :
 Worm   327 K------TSMITIKRLLEPEMKK---------------IKSIEALRPYVPQRV-----------I 359

  Fly   354 NTEEVIMNFSTPKVQRFLMSLKVSFADKDPKDICCLVFVERRYTCKCIYGLLL--NYIQSTPELR 416
            ...|::..|: |:.|:..|.|:.:      :.:..::||::||..   |.|||  .:|:|.....
 Worm   360 RLFEILETFN-PEFQKERMKLEKA------EHLSAIIFVDQRYIA---YSLLLMMRHIKSWEPKF 414

  Fly   417 NVLTPQFMV---GRNNISPDFESVLERKWQKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFI 478
            ..:.|.::|   |||..|.|.:.:.:|  |...:::|.....|.:|.:||||||:||:.||.|..
 Worm   415 KFVNPDYVVGASGRNLASSDSQGLHKR--QTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIK 477

  Fly   479 LDPVKTFNMYVQSKGRARTTEAKFVLFTADKERE------KTIQQI-----YQYRKAHNDIAEYL 532
            .|.......|||||||||...:::|:...:|:..      |..|||     .::|..:|.| |..
 Worm   478 FDRPLDMRSYVQSKGRARRAGSRYVITVEEKDTAACDSDLKDFQQIEKILLSRHRTVNNPI-EDD 541

  Fly   533 KDRVLEKTEPELYEIKGHFQDDIDPFTNE-NGAVLLPNNALAILHRYCQTIPTDAFGFVIPWFHV 596
            .||.      |.:::    ...::|:..| .||.|..:.|:|:::|||..:|:|.|..::|...:
 Worm   542 SDRF------EEFDV----DSQMEPYVVEKTGATLKMSTAIALINRYCSKLPSDIFTRLVPHNQI 596

  Fly   597 LQEDERDRIFGVSAKGKHVISINMPVNCMLRDTI-YSDPMDNVKTAKISAAFKACKVLYSLGELN 660
            :..:|.    ||:   |:...:.:|:|..::..| ..:||.|.|||:::.|.:||:.|:..|||:
 Worm   597 IPIEEN----GVT---KYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELD 654

  Fly   661 ERFVPKTLKERVASIADVHFEHWNKYGDSVTATVNKADKSKDRTYKTECPLEFYDALPRVGEICY 725
            :..:||. :|.:|.:.:...|..::|...:.|.|..:  .:.:.|..:......::.....:.|:
 Worm   655 DNLLPKG-RESIAKLLEHIDEEPDEYAPGIAAKVGSS--KRKQLYDKKIARALNESFVEADKECF 716

  Fly   726 AYEIFLEPQFESCEYTEHMYLN-----LQTPRNY----AILLRNKLPRLAEMPLFSNQGKLHVRV 781
            .|...|| :|...|.|    ||     .:.|.||    ..|...::|::...|:|..||.:.||:
 Worm   717 IYAFELE-RFREAELT----LNPKRRKFEDPFNYEYCFGFLSAKEIPKIPPFPVFLRQGNMKVRL 776

  Fly   782 ANAPLEVIIQNSEQLELLHQFHGMVFRDILKIWHP----------------FFVLDRRSKENSYL 830
            ..||.:..: .:.||:.:..||..:|..:|::...                ...|::|..:.||.
 Worm   777 IVAPKKTTV-TAAQLQEIQLFHNYLFTQVLQMCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYT 840

  Fly   831 VVPLILGAGEQKCFDWELMTNFRRLPQSHGSNVQQREQQPAPRPEDFEGKIVTQWYANYDKPML- 894
            :         ...:..|::.|...:|:.....|:::.:..|   ||::..||..||.|.::|:.
 Worm   841 I---------NMKYVSEVVANMENMPRIPKDEVRRQYKFNA---EDYKDAIVMPWYRNLEQPVFY 893

  Fly   895 -VTKVHRELTPLSYMEKNQQDKTYYEFTMSKYGNRIGDVVHKDKFMIEV---------------- 942
             |.::..|..|.|.. .:...:|:.|:.:.||...|.|   :::.:::|
 Worm   894 YVAEILPEWRPSSKF-PDTHFETFNEYFIKKYKLEIYD---QNQSLLDVDFTSTRLNLLQPRIQN 954

  Fly   943 -----RDLTEQLTFYVHNRGKFNAKSK------AKMKVILIPELCFNFNFPGDLWLKLIFLPSIL 996
                 |.::...|..:......::|..      :..:.||:|||.........||..:..||||.
 Worm   955 QPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVIAALPSIF 1019

  Fly   997 NRMYFLLHAEALRKR-------------------------------------------------- 1011
            .|:..||..:.||:.
 Worm  1020 YRVNQLLLTDELRETILVKAFGKEKTKLDDNVEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSI 1084

  Fly  1012 -------------------FNTYL--------------------------------NLH------ 1019
                               ||..:                                .||
 Worm  1085 EDQERETRENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISD 1149

  Fly  1020 ---LLPFNGTDYMPRPLEIDYSLKRNVDPLG------NVIPT--EDIEEPKSLLEPMPTK----- 1068
               .|||...||..|       |..|.:.:|      :::|:  .|.:.|:....|||.:
 Worm  1150 EDDELPFVMHDYTAR-------LTSNRNGIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILGGP 1207

  Fly  1069 ---SIEASVANL--------------------------EITEFENPWQKYMEPVDLSRNLLSTYP 1104
               :::|.:|::                          ::|:.|..::|      |..:||....
 Worm  1208 GGLNVQALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLTKEEEQFKK------LQNDLLKQAK 1266

  Fly  1105 VELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNI--YGNRTPAKTNANVPALMPSKPTV 1167
            ..|:         ..||:| |.|      |.:....|.|:  ||:....:.:.|.|...|.  |:
 Worm  1267 ERLE---------ALEMSE-DME------KPRRLEDTVNLEDYGDDQENQEDENTPTNFPK--TI 1313

  Fly  1168 RGKVKPLLI-------LQKTVSKEHITPAEQGE-------------------------------- 1193
            ..:::.|.|       :....:|..:...|..|
 Worm  1314 DEEIEELSIGARKKQEIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQRSE 1378

  Fly  1194 ------------------FLAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEGTL 1240
                              .|.|:|.|:|||...:||.|.:||||||.:.|.||.....|.:||.|
 Worm  1379 EYVSHIDSDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKL 1443

  Fly  1241 TEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPP------GISLPHNVLALWRENPEFA 1299
            :..:||.|||.||........||:.:...:|....:||||      ....|:...|..::| |..
 Worm  1444 SFARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCYIPTCDFKAPNTDDAEEKDN-EIE 1507

  Fly  1300 KIIG-------PHNLRDLALGDEESLVKGNCSDINYNRFVEGCRANGQSFYAGADFSSEVNFCVG 1357
            :|:.       |.|.....:|.:.|  |.....|....|.:..|       .|.|..|.:.:  .
 Worm  1508 RILDGQVIEEKPENKTGWDIGGDVS--KSTTDGIETITFPKQAR-------VGNDDISPLPY--N 1561

  Fly  1358 LVT---IPNKVIADTLEALLGVIVKNYGLQHAFKMLEYF------KICRADIDKPLTQLLNLELG 1413
            |:|   |.:|.|||.:|||:||.:...|.....|::.:.      |..::|:..||.:.::..
 Worm  1562 LLTQQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTP-- 1624

  Fly  1414 GKKMRANVNTTEIDGFLINHY------YLEKNLGYTFKDRRYLLQALTHPSYPTNRITGSYQELE 1472
             ....|::|      ||.|.:      .||:.:||.||:|.||:||.||.||..||:||.||.||
 Worm  1625 -TNPNASLN------FLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLE 1682

  Fly  1473 FIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIIS 1537
            |:|||:||::|:.|:||::.:.:||.||||||||||||..|.:.|:.......:|....|..:|.
 Worm  1683 FLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHMIE 1747

  Fly  1538 KFV------NFQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPP 1596
            |||      ||.       ||:        :.:...:..::|:|
 Worm  1748 KFVKLCSERNFD-------TNF--------NAEMYMVTTEEEID--------------------- 1776

  Fly  1597 KGEFNMSTNVDVPKALGDVLEALIAAVYLDC-RDLQRTWEVIFNLFEPELQEFTRKVPINHIRQL 1660
            :|:   ..:::||||:||:.|::..|:|||. |:|..||:|||::....::......|.:.||:|
 Worm  1777 EGQ---EEDIEVPKAMGDIFESVAGAIYLDSGRNLDTTWQVIFHMMRGTIELCCANPPRSPIREL 1838

  Fly  1661 VEHKHAKPVFS--SPIVEGETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQQLSKCD 1721
            :|.:.:|..||  ..|:|...|.|:.:   :...::..|.|.|...||.:|||.||:.|.:.:
 Worm  1839 MEFEQSKVRFSKMERILESGKVRVTVE---VVNNMRFTGMGRNYRIAKATAAKRALKYLHQIE 1898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792	80/204 (39%)
		Dicer_PBD	241..343	CDD:277191	22/122 (18%)
		SF2_C_dicer	360..506	CDD:350189	49/150 (33%)
		Dicer_dimer	571..670	CDD:460900	31/99 (31%)
		PAZ	843..1004	CDD:198017	40/189 (21%)
		RIBOc	1194..1391	CDD:238333	67/212 (32%)
		RIBOc	1448..1649	CDD:238333	73/207 (35%)
		dsrm	1653..1717	CDD:425434	22/65 (34%)
dcr-1	NP_498761.2	DEXHc_dicer	11..213	CDD:350792	80/204 (39%)
		Dicer_PBD	248..343	CDD:277191	18/103 (17%)
		SF2_C_dicer	357..505	CDD:350189	50/170 (29%)
		Dicer_dimer	571..664	CDD:460900	31/100 (31%)
		PAZ_dicer_like	836..956	CDD:239209	26/135 (19%)
		RIBOc	1395..1520	CDD:197778	42/125 (34%)
		RIBOc	1659..1824	CDD:238333	73/203 (36%)
		DSRM_DICER	1832..1895	CDD:380680	21/65 (32%)