DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcr-2 and drsh-1

DIOPT Version :9

Sequence 1:	NP_523778.2	Gene:	Dcr-2 / 36993	FlyBaseID:	FBgn0034246	Length:	1722	Species:	Drosophila melanogaster
Sequence 2:	NP_492599.1	Gene:	drsh-1 / 172830	WormBaseID:	WBGene00009163	Length:	1086	Species:	Caenorhabditis elegans

Alignment Length:	993	Identity:	193/993 - (19%)
Similarity:	323/993 - (32%)	Gaps:	340/993 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   838 AGEQKCFDWELMTNFRRLPQSHGSNVQQREQQPAPRPE----------------DFEG-KIVT-- 883
            |||.|..|.:         :|:|.|:.....:..|.|.                :||| .::|
Worm   292 AGEDKAIDCK---------KSNGENLHYYTLRVTPLPSENQLYRTHMAINGEEFEFEGFSLITHA 347

  Fly   884 ------------QWYANYDKPMLVTKVHRELTPLSYMEKNQQDK----TYYE-FTMSKYGNR--- 928
                        ::..:|:..::     .|..|....:....|.    .::| |.|..:..|
Worm   348 PLPDCMTRAPICKYSMDYEFQLV-----EEFMPDECFDPEDCDMLFEYIFHEIFEMLDFELRPKH 407

  Fly   929 -IGDV-----VHKDKFMIEVRDLTEQLTFYVHNRGKFNAKSKAKMKVILIPE----LC------F 977
             ..||     :|.....::.:|...||.........|.:|..::   |:.||    ||      |
Worm   408 IPSDVESCPMIHIMPRFVQTKDDLVQLWSSKTVLAYFTSKGSSE---IMSPEDVNRLCDAQIDQF 469

  Fly   978 NFN---FPGDLWLKLIFLPSILNRMYF----------LLHAEALRKRFNTYLNLHLLPFNGTDYM 1029
            ..|   ....:.|...|.||.:...:|          ::| .|:|.:..|.::|
Worm   470 TRNTSKHKQSIVLNTKFKPSAIRADWFERDEEKKEVYVVH-NAIRAQTYTAISL----------- 522

  Fly  1030 PRPLEIDYSLKRNV-DPLGNVIPTEDIEEPKSLLEPMPTKSIEASVANLEITEFENPWQKYME-- 1091
            ||...::.:|.:.: :...:.:..:|.|:.|:.||.:  |....|..||::.|   |...::|
Worm   523 PRIAFLEKTLNKMIQEKQSSGVYNKDFEKTKNELEHL--KRENRSARNLKLRE---PVAGFIETG 582

  Fly  1092 -PVDLSRNLLSTYPVELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAK--- 1152
             ..|::.:::.|........|:||:....|:.|..|.|:........|....:.||  ||..
Worm   583 LKPDVAAHVVMTILACHHIRYNFSLDVFEEVIEYKFNDRRVIELALMHSSFKSHYG--TPIDHVK 645

  Fly  1153 ---TNANVPALMPS-----KPTVRGKVKPLLILQKTVSKEHITPAEQGEFLAAITASSAADVFDM 1209
               ||........:     |..|.|.:....|::.|                    |....:...
Worm   646 NMITNCGYRRKYGAEDKREKKRVAGIMSLFNIMKGT--------------------SGGEPILHN 690

  Fly  1210 ERLEILGDSFLKLSATLYLASKYSDWNEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPR 1274
            ||||.|||:.::|..:.:|....:...||.|...::.||.||||          .||
Worm   691 ERLEYLGDAVVELIVSHHLYFMLTHHFEGGLATYRTALVQNRNL----------ATL-------- 737

  Fly  1275 YTWLPPGISLPHNVLALWRENPEFAKIIGPHNLRDLALGDEESLVKGNCSDINYNRFVEGCRANG 1339
                                                                     .:.||.:.
Worm   738 ---------------------------------------------------------AKNCRIDE 745

  Fly  1340 QSFYA-GADFSSEVNFCVGLVTIPNKVIADTLEALLGVIVKNYGLQHAFKMLEYFKICRADIDKP 1403
            ...|: |||..:...|        ...:|:..||::..|..:.||.....:..........:.|.
Worm   746 MLQYSHGADLINVAEF--------KHALANAFEAVMAAIYLDGGLAPCDVIFSKAMYGHQPVLKE 802

  Fly  1404 LTQLLN-LELGGKKMRANVNTTEIDGFLINHYYLEKNLGYTFKDRRYLLQALTHPSYPTNRIT-G 1466
            ....:| .||..:..:.:.:.:.|...|...:.||:.||..|.:.|.|.:|.|..:.|.|.:| |
Worm   803 KWDHINEHELKREDPQGDRDLSFITPTLSTFHALEERLGIQFNNIRLLAKAFTRRNIPNNDLTKG 867

  Fly  1467 SYQELEFIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAK 1531
            ..|.||::||::|..::|.:::......:.|.::.||::||:|.|.|.:|
Worm   868 HNQRLEWLGDSVLQLIVSDFLYRRFPYHHEGHMSLLRTSLVSNQTQAVVC--------------- 917

  Fly  1532 LSEIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPP 1596
                                                    |:|..|
Worm   918 ----------------------------------------DDLGFT------------------- 923

  Fly  1597 KGEFNMSTNVDVP----KALGDVLEALIAAVYLDCRDLQRTWEVIFNLFEPELQEFTRKVPIN-- 1655
              ||.:......|    |...|::||.|.|:|:| |.::.....|..:|.|.|:.|......|
Worm   924 --EFVIKAPYKTPELKLKDKADLVEAFIGALYVD-RGIEHCRAFIRIVFCPRLKHFIESEKWNDA 985

  Fly  1656 --HIRQLVEHKHAKPVFSSPI--------VEGET---VMVSCQFTCMEKTIKVYGFG-------- 1699
              |::|...... .|..|.|.        :||.|   :.          .|.||..|
Worm   986 KSHLQQWCLAMR-DPSSSEPDMPEYRVLGIEGPTNNRIF----------KIAVYYKGKRLASAAE 1039

  Fly  1700 SNKDQAKLSAAKHALQQL 1717
            ||..:|:|..|:.||..|
Worm  1040 SNVHKAELRVAELALANL 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	MPH1	6..542	CDD:224036
		DEXDc	22..173	CDD:238005
		Dicer_PBD	241..343	CDD:277191
		HELICc	<438..495	CDD:197757
		Dicer_dimer	572..665	CDD:281376
		PAZ	843..1004	CDD:198017	38/228 (17%)
		RIBOc	1194..1391	CDD:238333	34/197 (17%)
		Rnc	1433..1719	CDD:223644	70/313 (22%)
		RIBOc	1448..1649	CDD:238333	43/205 (21%)
		dsrm	1653..1717	CDD:278464	20/86 (23%)
drsh-1	NP_492599.1	RIBOc	672..793	CDD:197778	36/223 (16%)
		rnc	833..1058	CDD:234633	70/313 (22%)
		RIBOc	848..976	CDD:197778	43/204 (21%)
		DSRM	985..1058	CDD:214634	20/84 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910