Protein Alignment Dcr-2 and drsh-1

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_492599.1
• Gene: drsh-1 / 172830
• WormBaseID: WBGene00009163
• Length: 1086
• Species: Caenorhabditis elegans
• Alignment Length: 993
• Identity: 193/993 - (19%)
• Similarity: 323/993 - (32%)
• Gaps: 340/993 - (34%)

  Fly   838 AGEQKCFDWELMTNFRRLPQSHGSNVQQREQQPAPRPE----------------DFEG-KIVT-- 883
            |||.|..|.:         :|:|.|:.....:..|.|.                :||| .::|
 Worm   292 AGEDKAIDCK---------KSNGENLHYYTLRVTPLPSENQLYRTHMAINGEEFEFEGFSLITHA 347

  Fly   884 ------------QWYANYDKPMLVTKVHRELTPLSYMEKNQQDK----TYYE-FTMSKYGNR--- 928
                        ::..:|:..::     .|..|....:....|.    .::| |.|..:..|
 Worm   348 PLPDCMTRAPICKYSMDYEFQLV-----EEFMPDECFDPEDCDMLFEYIFHEIFEMLDFELRPKH 407

  Fly   929 -IGDV-----VHKDKFMIEVRDLTEQLTFYVHNRGKFNAKSKAKMKVILIPE----LC------F 977
             ..||     :|.....::.:|...||.........|.:|..::   |:.||    ||      |
 Worm   408 IPSDVESCPMIHIMPRFVQTKDDLVQLWSSKTVLAYFTSKGSSE---IMSPEDVNRLCDAQIDQF 469

  Fly   978 NFN---FPGDLWLKLIFLPSILNRMYF----------LLHAEALRKRFNTYLNLHLLPFNGTDYM 1029
            ..|   ....:.|...|.||.:...:|          ::| .|:|.:..|.::|
 Worm   470 TRNTSKHKQSIVLNTKFKPSAIRADWFERDEEKKEVYVVH-NAIRAQTYTAISL----------- 522

  Fly  1030 PRPLEIDYSLKRNV-DPLGNVIPTEDIEEPKSLLEPMPTKSIEASVANLEITEFENPWQKYME-- 1091
            ||...::.:|.:.: :...:.:..:|.|:.|:.||.:  |....|..||::.|   |...::|
 Worm   523 PRIAFLEKTLNKMIQEKQSSGVYNKDFEKTKNELEHL--KRENRSARNLKLRE---PVAGFIETG 582

  Fly  1092 -PVDLSRNLLSTYPVELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAK--- 1152
             ..|::.:::.|........|:||:....|:.|..|.|:........|....:.||  ||..
 Worm   583 LKPDVAAHVVMTILACHHIRYNFSLDVFEEVIEYKFNDRRVIELALMHSSFKSHYG--TPIDHVK 645

  Fly  1153 ---TNANVPALMPS-----KPTVRGKVKPLLILQKTVSKEHITPAEQGEFLAAITASSAADVFDM 1209
               ||........:     |..|.|.:....|::.|                    |....:...
 Worm   646 NMITNCGYRRKYGAEDKREKKRVAGIMSLFNIMKGT--------------------SGGEPILHN 690

  Fly  1210 ERLEILGDSFLKLSATLYLASKYSDWNEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPR 1274
            ||||.|||:.::|..:.:|....:...||.|...::.||.||||          .||
 Worm   691 ERLEYLGDAVVELIVSHHLYFMLTHHFEGGLATYRTALVQNRNL----------ATL-------- 737

  Fly  1275 YTWLPPGISLPHNVLALWRENPEFAKIIGPHNLRDLALGDEESLVKGNCSDINYNRFVEGCRANG 1339
                                                                     .:.||.:.
 Worm   738 ---------------------------------------------------------AKNCRIDE 745

  Fly  1340 QSFYA-GADFSSEVNFCVGLVTIPNKVIADTLEALLGVIVKNYGLQHAFKMLEYFKICRADIDKP 1403
            ...|: |||..:...|        ...:|:..||::..|..:.||.....:..........:.|.
 Worm   746 MLQYSHGADLINVAEF--------KHALANAFEAVMAAIYLDGGLAPCDVIFSKAMYGHQPVLKE 802

  Fly  1404 LTQLLN-LELGGKKMRANVNTTEIDGFLINHYYLEKNLGYTFKDRRYLLQALTHPSYPTNRIT-G 1466
            ....:| .||..:..:.:.:.:.|...|...:.||:.||..|.:.|.|.:|.|..:.|.|.:| |
 Worm   803 KWDHINEHELKREDPQGDRDLSFITPTLSTFHALEERLGIQFNNIRLLAKAFTRRNIPNNDLTKG 867

  Fly  1467 SYQELEFIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAK 1531
            ..|.||::||::|..::|.:::......:.|.::.||::||:|.|.|.:|
 Worm   868 HNQRLEWLGDSVLQLIVSDFLYRRFPYHHEGHMSLLRTSLVSNQTQAVVC--------------- 917

  Fly  1532 LSEIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPP 1596
                                                    |:|..|
 Worm   918 ----------------------------------------DDLGFT------------------- 923

  Fly  1597 KGEFNMSTNVDVP----KALGDVLEALIAAVYLDCRDLQRTWEVIFNLFEPELQEFTRKVPIN-- 1655
              ||.:......|    |...|::||.|.|:|:| |.::.....|..:|.|.|:.|......|
 Worm   924 --EFVIKAPYKTPELKLKDKADLVEAFIGALYVD-RGIEHCRAFIRIVFCPRLKHFIESEKWNDA 985

  Fly  1656 --HIRQLVEHKHAKPVFSSPI--------VEGET---VMVSCQFTCMEKTIKVYGFG-------- 1699
              |::|...... .|..|.|.        :||.|   :.          .|.||..|
 Worm   986 KSHLQQWCLAMR-DPSSSEPDMPEYRVLGIEGPTNNRIF----------KIAVYYKGKRLASAAE 1039

  Fly  1700 SNKDQAKLSAAKHALQQL 1717
            ||..:|:|..|:.||..|
 Worm  1040 SNVHKAELRVAELALANL 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792
		Dicer_PBD	241..343	CDD:277191
		SF2_C_dicer	360..506	CDD:350189
		Dicer_dimer	571..670	CDD:460900
		PAZ	843..1004	CDD:198017	38/228 (17%)
		RIBOc	1194..1391	CDD:238333	34/197 (17%)
		RIBOc	1448..1649	CDD:238333	43/205 (21%)
		dsrm	1653..1717	CDD:425434	20/86 (23%)
drsh-1	NP_492599.1	RIBOc	672..793	CDD:197778	36/223 (16%)
		Rnc	835..1058	CDD:440336	70/311 (23%)