Protein Alignment Dcr-2 and drh-3

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: NP_492161.3
• Gene: drh-3 / 172546
• WormBaseID: WBGene00008400
• Length: 1119
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 135/574 - (23%)
• Similarity: 231/574 - (40%)
• Gaps: 117/574 - (20%)

  Fly     5 EIKPRGYQLRLVD-HLTKSNGIVYLPTGSGKTFVAIL-----VLKRFSQDFDKPIESGGKRALFM 63
            |:..|.||..||. .|...|.::..|||||||.|||.     :.:|.||  .||     .|.:.:
 Worm   368 ELVLRTYQEELVQPALEGKNCVIVAPTGSGKTEVAIYAALKHIEERTSQ--GKP-----SRVVLL 425

  Fly    64 CNTVELARQQAMAVRRCTN--FKV-GFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMV-- 123
            ...:.|..||.....:..|  ::| ||:..|..|....|   .||:....|.|.|.|:.::|:
 Worm   426 VPKIPLVGQQKDRFLKYCNGMYEVNGFHGSESSVSGTGR---RDEVIATHVSVMTPQILINMLQS 487

  Fly   124 ----TQTYVALSSLSVVIIDECHHGTGHHPFREFMRLFTIANQT------KLPRVVGLT---GVL 175
                .:.||  |..|::|.||.|....:||       :.:.||.      :.|:::|||   .|.
 Worm   488 VRQNERLYV--SDFSMMIFDEVHKAAKNHP-------YVLINQMVQEWKYEKPQIIGLTASLSVK 543

  Fly   176 IKG--------NEITNVATKLKELEITYRGNIITVSDTKEMENVMLYATKPTE-VMVSFPHQEQV 231
            :.|        |:|.|:      |.:....::.|::....::.:..:..||.: |.:..|.:|.:
 Worm   544 VDGQKDENQMLNDIYNM------LALINAPHLSTITRQSSIDELNEHVGKPDDSVELCLPAKENI 602

  Fly   232 LT--VTRLISAEIEKFYVSLDLMNIGVQPIRRSKSLQCLRDPSKKSFVKQLFNDF-LYQMKEYGI 293
            |.  :.|.::....||...|..|         |||     .....:....:.|.| ..|.|.|..
 Worm   603 LRDYIERYLNHAHGKFLEELASM---------SKS-----TGRNNTIPPNMINTFKKNQPKNYEY 653

  Fly   294 YAASI-AIISLIVEFDIKRR-----QAETLSVKLMHRTALTLCE-----KIRHLLVQKLQD---- 343
            |.:.: .||..:.:.::..:     .|:.:.|.|..|..:.|..     |.....:.||.:
 Worm   654 YDSLLQGIIQELNKLNVPEKWNSQTWAKYMKVYLEARGIVDLMPAMVAFKYMEKAIGKLNESHSE 718

  Fly   344 ----MTYDDDDDNVNTEEVIMNFSTPKVQRFLMSLKVSFADKDPKDICCLVFVERRYTCKCIYGL 404
                .|:..|.|.:  ::.|.:.....|.|...:|...|.......:  ::||.:|.|.:.:..
 Worm   719 TVEYSTFIKDHDTL--KQTIQSVEPEIVLRLKNTLTNQFHVAPESRV--IIFVTQRSTAQRVSD- 778

  Fly   405 LLNYIQSTPELRNVLTPQ--FMVGRNNISPDFESVLERKWQKSAIQQFRDGNANLMICSSVLEEG 467
            .||..:...:..|.....  :::|.|......::..|   |:..:.:|.:|...:::.:||:|||
 Worm   779 FLNESKVLDQFGNYGEQMVGYVLGTNKQGAVQQTSQE---QQLTLDKFNNGRLKVIVATSVVEEG 840

  Fly   468 IDVQACNHVFILDPVKTFN-------MYVQSKGRARTTEAKFVLFTADKEREKT 514
            :||.|||.:.      .:|       ..||.:||||...::.||.:......:|
 Worm   841 LDVTACNLII------KYNCSSGSAIQLVQQRGRARAKNSRSVLLSVKSSINET 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792	63/229 (28%)
		Dicer_PBD	241..343	CDD:277191	23/113 (20%)
		SF2_C_dicer	360..506	CDD:350189	36/154 (23%)
		Dicer_dimer	571..670	CDD:460900
		PAZ	843..1004	CDD:198017
		RIBOc	1194..1391	CDD:238333
		RIBOc	1448..1649	CDD:238333
		dsrm	1653..1717	CDD:425434
drh-3	NP_492161.3	DEAD-like_helicase_N	369..572	CDD:475120	62/227 (27%)
		MPH1	372..>935	CDD:440728	134/570 (24%)
		RLR_C	948..1062	CDD:276942