Protein Alignment Dcr-2 and Drosha

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: XP_006520084.1
• Gene: Drosha / 14000
• MGIID: 1261425
• Length: 1393
• Species: Mus musculus
• Alignment Length: 1460
• Identity: 249/1460 - (17%)
• Similarity: 439/1460 - (30%)
• Gaps: 623/1460 - (42%)

  Fly   488 YVQSKGRARTTEAKFVLFTADKEREK------------TIQQIY--QYRKAHNDIA--------- 529
            |.....|.||...:...:...:||::            ::::.|  :|:::....|
Mouse   283 YRSDYDRGRTPPPRHRSYERSRERDRERHRHREARRSPSLERSYKKEYKRSGRSYALPVAPEPAG 347

  Fly   530 --EYLKDRVLEKTE-------------PELYEIKGHFQDDIDPFTNENGAVLLPNNALAILHRYC 579
              ..|...:::.||             |...:.:..::::.|.:::..|:. ...|..:|..:..
Mouse   348 CTPELPGEMIKTTESWAPPPENVNHRSPSREKKRARWEEEKDRWSDSQGSG-KEKNYTSIKEKEA 411

  Fly   580 QTIPTDAFGFVIPWFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRDTIY-SDPMDNVKTAKI 643
            :.:|.:.          .:|:|.:.:..|.            :.|...::.| |||||.|..:.:
Mouse   412 EEVPPEK----------TEEEEEELLKPVW------------IRCTHSESYYSSDPMDQVGDSTV 454

  Fly   644 SAAFKACKVLY-----SLGELNERF--------VPKTLKERVASIADVHFEHWNKYGDSVTATVN 695
            ....: .:.||     .||...|:.        .|||..:.                |..:::.:
Mouse   455 VGTSR-LRDLYDKFEEELGNRQEKAKAARPPWEPPKTKLDE----------------DLESSSES 502

  Fly   696 KADKSKDRTYKTECPLEFYDALPRV------------------------GEIC------------ 724
            :.:...|.|..:....|.:|.:..:                        |.:|
Mouse   503 ECETDDDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIR 567

  Fly   725 -----------------------YAYEI-------FLEPQFESCEYTEHMYLNLQTPRNYAILLR 759
                                   :.|.|       ||..:....||.:|.|:
Mouse   568 HSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYI------------- 619

  Fly   760 NKLPRLAEMPLFSNQGKLHVRVANAPL----------------EVIIQN--SEQLELLHQFHGMV 806
                 .....:|:     |..:.|.||                |::.:|  .:.|||...|   :
Mouse   620 -----FEGFSMFA-----HAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLF---L 671

  Fly   807 FRDILKI--WH---PFFVLDRRSKENSYLVVPLILGAGEQKCFDWELMTNFRRLPQSHGSNVQQR 866
            |||||::  |:   |.|       |:|           ...|..:..|..|.|.....|..|...
Mouse   672 FRDILELYDWNLKGPLF-------EDS-----------PPCCPRFHFMPRFVRFLPDGGKEVLSM 718

  Fly   867 EQ--------QPAPRPEDFEGKIVTQW-------YANYDKPMLVTK------------------- 897
            .|        ..|..||: |...:.||       ||...|.|:||.
Mouse   719 HQILLYLLRCSKALVPEE-EIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFN 782

  Fly   898 ---------VHRELTP--LSYMEKNQQDKTYYEFTMSKY--GNRIGDVVHKDKFMIEVRDLTEQL 949
                     ||..:.|  |||....|..|.:..:...::  .|. ..|...||..:..|:
Mouse   783 PEVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANS-PKVKQTDKQKLAQRE----- 841

  Fly   950 TFYVHNRGKFNAKSKAKMKVILIPELCFNFNFPG--------DLWLKLIFLPSILNRMYF---LL 1003
                      .|..|.:.|..:..|:....:..|        |:....:.||.:.:.:.:   |:
Mouse   842 ----------EALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLM 896

  Fly  1004 HAEALRKRFNTYLNLHLLPFNGTDYMPRPLEIDYSLKRNVDPLGNVIPTEDIEEPKSLLEPMPTK 1068
            |.:.|                          |.|:.                 :.:.||:
Mouse   897 HLDKL--------------------------IGYTF-----------------QDRCLLQ----- 913

  Fly  1069 SIEASVANLEITEFENPWQKYMEPVDLSRNLLSTYPVELDYYYHFSVGNVCEMNEMDFEDKEYWA 1133
                    |.:|...:.....|.| |.:||.||.                |.:.:..:.|::.
Mouse   914 --------LAMTHPSHHLNFGMNP-DHARNSLSN----------------CGIRQPKYGDRKV-- 951

  Fly  1134 KNQFHMPTGNIYGNRTPAKTNANVPALMPSKPTVRGK-VKPLLILQKTVSKEHITPAEQGEFLAA 1197
             :..||                            |.| :..|:.:...:.::..||:.
Mouse   952 -HHMHM----------------------------RKKGINTLINIMSRLGQDDPTPSR------- 980

  Fly  1198 ITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEGTLTEVKSKLVSNRNLLFCLIDADI 1262
                    :...||||.|||:.::...:::|...:....||.|...::.:|.|::|      |.:
Mouse   981 --------INHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHL------AML 1031

  Fly  1263 PKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAKIIGPHNLRDLALGDEESLVKGNCSDIN 1327
            .|.|...:|                  .|:...|:..:.                      ||:.
Mouse  1032 AKKLELDRF------------------MLYAHGPDLCRE----------------------SDLR 1056

  Fly  1328 YNRFVEGCRANGQSFYAGADFSSEVNFCVGLVTIPNKVIADTLEALLGVIVKNYGLQHAFKMLEY 1392
            :                                    .:|:..|||:|.:.....|:.|.::  :
Mouse  1057 H------------------------------------AMANCFEALIGAVYLEGSLEEAKQL--F 1083

  Fly  1393 FKICRADIDKPLTQL-LNLELGGKKMRANVNT----TEIDGFLINHYYLEKNLGYTFKDRRYLLQ 1452
            .::...|.|  |.:: ||..|...::: ..||    .|....|......|:.:|..|...|.|.:
Mouse  1084 GRLLFNDPD--LREVWLNYPLHPLQLQ-EPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLAR 1145

  Fly  1453 ALTHPSYPTNRIT-GSYQELEFIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACIC 1516
            |.|..:...|.:| |..|.:||:||:|:..:.:.|:|.:....:.|.||.|||:||||.|
Mouse  1146 AFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRT----- 1205

  Fly  1517 VRHRLHFFILAENAKLSEIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPH 1581
                        .||::|.:.       .|.:.:||                      |.|:.|.
Mouse  1206 ------------QAKVAEELG-------MQEYAITN----------------------DKTKRPV 1229

  Fly  1582 ANKCISQEAEKGVPPKGEFNMSTNVDVPKALGDVLEALIAAVYLDCRDLQRTWEVIFNLFEPELQ 1646
            |.:                        .|.|.|:||:.|||:|:| :||:.....:...|.|.|:
Mouse  1230 ALR------------------------TKTLADLLESFIAALYID-KDLEYVHTFMNVCFFPRLK 1269

  Fly  1647 EFTRK-------------------------VPINHIRQLVEHKHAKPVFSSPIVEGETVMVSCQF 1686
            ||...                         :|:....|.|...||:....:...:||  .:.|
Mouse  1270 EFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGE--RIGC-- 1330

  Fly  1687 TCMEKTIKVYGFGSNKDQAKLSAAKHALQQ 1716
                      |.|.:..||::.||..||::
Mouse  1331 ----------GKGPSIQQAEMGAAMDALEK 1350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792
		Dicer_PBD	241..343	CDD:277191
		SF2_C_dicer	360..506	CDD:350189	4/17 (24%)
		Dicer_dimer	571..670	CDD:460900	21/112 (19%)
		PAZ	843..1004	CDD:198017	41/218 (19%)
		RIBOc	1194..1391	CDD:238333	29/196 (15%)
		RIBOc	1448..1649	CDD:238333	52/201 (26%)
		dsrm	1653..1717	CDD:425434	16/64 (25%)
Drosha	XP_006520084.1	RSRP	237..>337	CDD:293674	8/53 (15%)
		RIBOc	978..1098	CDD:238333	33/220 (15%)
		Rnc	1124..1352	CDD:440336	72/312 (23%)