Protein Alignment Dcr-2 and drosha

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: XP_061514326.1
• Gene: drosha / 1277864
• VectorBaseID: AGAMI1_003769
• Length: 1500
• Species: Anopheles gambiae
• Alignment Length: 1224
• Identity: 222/1224 - (18%)
• Similarity: 374/1224 - (30%)
• Gaps: 511/1224 - (41%)

  Fly   608 VSAKGKHVISINMPVNCMLRDTIYSDP--MDNVKTAKISAAFKACKVLYSLGELNERFVPKTLKE 670
            ::||.||.:.:::       |..|:||  |::....:.||..:...:.:......|.| ||.:..
Mosquito   343 LTAKIKHPLRLHV-------DLWYNDPGEMNDGPLCRCSARSRRTGIRHGKYPGEEGF-PKCIPN 399

  Fly   671 RVASIADVHFEHWNKYGDSVTATVNKADKSKDRTYKTECPLEFYDALPRVGEICYAYEIFL---- 731
            .                       |.|||..........|..|....|.:  |.:....||
Mosquito   400 S-----------------------NNADKLYHYRITISPPTNFLTKTPTI--IKHDQHEFLFEGF 439

  Fly   732 -----EP--QFESC-------EYTEHMYLNLQTPRNYAILLRNKLPRLAEMPLFSNQGKLHVRVA 782
                 ||  :..:|       ||| .:|:..|.|.|:.|         .|:.||..
Mosquito   440 SLLAHEPIGELPTCKVIRFNIEYT-ILYIEEQMPENFTI---------RELNLFDR--------- 485

  Fly   783 NAPLEVIIQNSEQLELLHQFHGMVFRDILKIWHPFFVLDRRSKENSYLVVPLILGAGE-QKCFDW 846
                                  .:||::|::      :|       :.|.|  .|:|| ..|..:
Mosquito   486 ----------------------YLFRELLEL------VD-------FTVQP--SGSGEDSSCPCY 513

  Fly   847 ELMTNFRRLPQSHGSNVQQREQ-------QPAPR-PEDFEGKIV----TQW--YANYDKPMLVTK 897
            ..:..|.|....:|..|....:       ...|. |.|...:::    .:|  |.:|.|.|:|:.
Mosquito   514 HFLPRFVRDLPDNGKEVLAMSEVLRYLLDNSGPLVPPDMLKEMMDMSQNEWQDYVDYVKGMVVSN 578

  Fly   898 ------------------------------------VHRELTP--LSYMEKNQQDKTYYEFTMSK 924
                                                ||..:.|  |||....:..|.:.|:.  |
Mosquito   579 PGMKPCSVRVDQLDRNVGDVPEANAIDENGLVHPVIVHFGIRPPQLSYAGNPEYQKAWREYI--K 641

  Fly   925 YGNRIGDV---VHKDKFMIEVRDLTEQLTFYVHNRGKFNAKSKAKMKVILIPELCFNFNFPG--- 983
            :.:.|.::   ..:||..:|.:: ...|...:..|.|.|.......|.         |:..|
Mosquito   642 FRHLIANMSKPSFEDKRKLEAKE-NRLLEMRMQGRMKRNITIAVSAKA---------FHRTGIMC 696

  Fly   984 DLWLKLIFLPSILNRMYFLLHAEALRKRFNTYLNLHLLPFNGTDYMPRPLEIDYSLKRNVDPLGN 1048
            |:....:.:|.:...:           ||:..||: |..:.|..:..|     |:|:
Mosquito   697 DMVQHAMLIPVLTGHL-----------RFHRSLNV-LERYIGYTFTNR-----YTLQ-------- 736

  Fly  1049 VIPTEDIEEPKSLLEPMPTKSIEASVANLEITEFENPWQKYMEPVDLSRNLLSTYPVELDYYYHF 1113
                      .:|..|...::...           ||        |.:||.|:.
Mosquito   737 ----------LALTHPSYKENFGT-----------NP--------DHARNSLTN----------- 761

  Fly  1114 SVGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPALMPSKPTVRGKVKPLLILQ 1178
                 |.:.:.::.|::....|                              |.:..:..|:.:.
Mosquito   762 -----CGIRQPEYGDRKIHYMN------------------------------TRKRGINTLISIM 791

  Fly  1179 KTVSKEHITPAEQGEFLAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEGTLTEV 1243
            ....|||.|.               :::...||||.|||:.::...:::|...:.|..||.|...
Mosquito   792 SRFGKEHETD---------------SNITHNERLEFLGDAVVEFITSIHLFHMFPDLEEGGLATY 841

  Fly  1244 KSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAKIIGPHNLR 1308
            ::.:|.|::|      |.:.|.|:..:|
Mosquito   842 RAAIVQNQHL------AVLAKKLHLEEF------------------------------------- 863

  Fly  1309 DLALGDEESLVKGNCSDINYNRFVEGCRANGQSFYA-GADFSSEVNFCVGLVTIPNKVIADTLEA 1372
                                            ..|| |:|...|:..        ...:|:..||
Mosquito   864 --------------------------------MLYAHGSDLCHELEL--------RHALANCFEA 888

  Fly  1373 LLGVIVKNYGLQHAFKMLEYFKICRAD------IDKPLTQLLNLE-LGGKKMRANVNTTEIDGF- 1429
            |:|.::.:.|::.|.::..|......|      ::.|...|...| ||.:.        .||.|
Mosquito   889 LMGALLLDGGIEVADRVFAYALFQEDDTLRGIWVNYPSHPLQEQEPLGDRH--------HIDSFE 945

  Fly  1430 -LINHYYLEKNLGYTFKDRRYLLQALTHPSYP-TNRITGSYQELEFIGDAILDFLISAYIFENNT 1492
             |......|.::|..|...|.|.:|.|..|.. ||...||.|.|||:||.:|..:.|.|::.:..
Mosquito   946 MLKTLTRFEDSIGVQFNHIRLLARAFTDRSIGFTNLTLGSNQRLEFLGDTVLQLICSEYLYRHFP 1010

  Fly  1493 KMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVNFQESQGHRVTNYVRIL 1557
            :.:.|.|:.|||:||||.|.|.:|
Mosquito  1011 EHHEGHLSLLRSSLVNNRTQAVVC----------------------------------------- 1034

  Fly  1558 LEEADVQPTPLDLDDELDMTELP-HANKCISQEAEKGVPPKGEFNMSTNVDVPKALGDVLEALIA 1621
                          |:|.||:.. ::|            ||.:..       .|...|:|||.:.
Mosquito  1035 --------------DDLGMTQYAVYSN------------PKADLK-------TKDRADLLEAFLG 1066

  Fly  1622 AVYLDCRDLQRTWEVIFNLFEPELQEFTRKVPINH-----------IRQLVEHKHAKPVFSSPIV 1675
            |:|:| :.|:...........|.||:|......|.           :|.:...:...||:.  ::
Mosquito  1067 ALYVD-KGLEYCEMFCHVCLFPRLQDFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPVYK--VI 1128

  Fly  1676 EGETVMVSCQFTCMEKT-IKVYGF-------------GSNKDQAKLSAAKHALQ 1715
            |           |...| .:||..             |.:..||:::|||.||:
Mosquito  1129 E-----------CTGPTNTRVYSVAVYFRGKRLACADGHSIQQAEMNAAKQALE 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792
		Dicer_PBD	241..343	CDD:277191
		SF2_C_dicer	360..506	CDD:350189
		Dicer_dimer	571..670	CDD:460900	15/63 (24%)
		PAZ	843..1004	CDD:198017	36/218 (17%)
		RIBOc	1194..1391	CDD:238333	31/197 (16%)
		RIBOc	1448..1649	CDD:238333	49/202 (24%)
		dsrm	1653..1717	CDD:425434	17/88 (19%)
drosha	XP_061514326.1	None